登録情報 | データベース: PDB / ID: 7prw |
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タイトル | The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp |
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要素 | - DNA (5'-D(*GP*TP*AP*CP*AP*GP*AP*AP*CP*AP*TP*TP*TP*TP*GP*TP*CP*CP*GP*TP*CP*GP*A)-3')
- DNA (5'-D(*TP*CP*GP*AP*CP*GP*GP*AP*CP*AP*AP*AP*AP*TP*GP*TP*TP*CP*TP*GP*TP*AP*C)-3')
- Glucocorticoid receptor糖質コルチコイド受容体
- Peroxisome proliferator-activated receptor gamma coactivator 1-alphaPPARγ
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キーワード | SIGNALING PROTEIN / nuclear receptor (核内受容体) / ligand-activated transcription factor / multi-domain (タンパク質ドメイン) / complex / agonist (アゴニスト) |
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機能・相同性 | 機能・相同性情報
positive regulation of mitochondrial DNA metabolic process / positive regulation of muscle tissue development / Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cellular respiration / positive regulation of fatty acid oxidation / steroid hormone binding / PTK6 Expression / neuroinflammatory response ...positive regulation of mitochondrial DNA metabolic process / positive regulation of muscle tissue development / Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cellular respiration / positive regulation of fatty acid oxidation / steroid hormone binding / PTK6 Expression / neuroinflammatory response / glucocorticoid metabolic process / : / microglia differentiation / maternal behavior / mammary gland duct morphogenesis / nucleus localization / astrocyte differentiation / : / lncRNA binding / 細胞呼吸 / cellular response to glucocorticoid stimulus / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / motor behavior / temperature homeostasis / regulation of gluconeogenesis / adrenal gland development / cellular response to steroid hormone stimulus / positive regulation of ATP biosynthetic process / response to starvation / intracellular glucose homeostasis / Β酸化 / response to dietary excess / estrogen response element binding / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / energy homeostasis / intracellular steroid hormone receptor signaling pathway / brown fat cell differentiation / core promoter sequence-specific DNA binding / positive regulation of gluconeogenesis / 消化 / cellular response to transforming growth factor beta stimulus / respiratory electron transport chain / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / TBP-class protein binding / steroid binding / cellular response to dexamethasone stimulus / mitochondrion organization / RNA splicing / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / synaptic transmission, glutamatergic / chromosome segregation / 糖新生 / transcription initiation at RNA polymerase II promoter / nuclear receptor binding / transcription coregulator activity / negative regulation of smooth muscle cell proliferation / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Hsp90 protein binding / circadian regulation of gene expression / Heme signaling / SUMOylation of intracellular receptors / Transcriptional activation of mitochondrial biogenesis / regulation of circadian rhythm / PPARA activates gene expression / PML body / spindle / chromatin DNA binding / 転写後修飾 / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of miRNA transcription / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / positive regulation of neuron apoptotic process / Regulation of RUNX2 expression and activity / nuclear receptor activity / positive regulation of DNA-binding transcription factor activity / Circadian Clock / sequence-specific double-stranded DNA binding / cellular response to oxidative stress / positive regulation of cold-induced thermogenesis / 遺伝子発現 / chromatin organization / DNA-binding transcription activator activity, RNA polymerase II-specific / protein-containing complex assembly / neuron apoptotic process / DNA-binding transcription factor binding / negative regulation of neuron apoptotic process / RNA polymerase II-specific DNA-binding transcription factor binding / Potential therapeutics for SARS / sequence-specific DNA binding / transcription coactivator activity / protein stabilization / DNA-binding transcription factor activity, RNA polymerase II-specific / ミトコンドリアマトリックス / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity類似検索 - 分子機能 PGC-1alpha, RNA recognition motif / PGC-1 / 糖質コルチコイド受容体 / 糖質コルチコイド受容体 / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / 核内受容体 ...PGC-1alpha, RNA recognition motif / PGC-1 / 糖質コルチコイド受容体 / 糖質コルチコイド受容体 / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily類似検索 - ドメイン・相同性 Velsecorat / デオキシリボ核酸 / DNA (> 10) / 糖質コルチコイド受容体 / PPARγ類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.502 Å |
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データ登録者 | Postel, S. / Edman, K. / Wissler, L. |
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資金援助 | 1件 |
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2023 タイトル: Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication. 著者: Postel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. / Froderberg Roth, L. / Beinsteiner, B. / ...著者: Postel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. / Froderberg Roth, L. / Beinsteiner, B. / Dainty, I. / Delaney, S. / Klaholz, B.P. / Billas, I.M.L. / Edman, K. |
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履歴 | 登録 | 2021年9月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年2月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年2月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_PubMed / _citation.title ..._citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2023年3月29日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年2月7日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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