+Open data
-Basic information
Entry | Database: PDB / ID: 7poj | ||||||
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Title | Prodomain bound BMP10 crystal form 2 | ||||||
Components | (Bone morphogenetic protein 10) x 2 | ||||||
Keywords | CYTOKINE / BMP10 bone morphogenetic protein prodomain TGFbeta signalling | ||||||
Function / homology | Function and homology information atrial cardiac muscle tissue morphogenesis / regulation of cardiac muscle hypertrophy in response to stress / positive regulation of sarcomere organization / positive regulation of cell proliferation involved in heart morphogenesis / ventricular cardiac muscle cell development / positive regulation of cartilage development / telethonin binding / negative regulation of cardiac muscle hypertrophy / Signaling by BMP / activin receptor signaling pathway ...atrial cardiac muscle tissue morphogenesis / regulation of cardiac muscle hypertrophy in response to stress / positive regulation of sarcomere organization / positive regulation of cell proliferation involved in heart morphogenesis / ventricular cardiac muscle cell development / positive regulation of cartilage development / telethonin binding / negative regulation of cardiac muscle hypertrophy / Signaling by BMP / activin receptor signaling pathway / heart trabecula formation / receptor serine/threonine kinase binding / adult heart development / Molecules associated with elastic fibres / negative regulation of endothelial cell migration / ventricular cardiac muscle tissue morphogenesis / cardiac muscle cell proliferation / sarcomere organization / positive regulation of cardiac muscle hypertrophy / positive regulation of SMAD protein signal transduction / regulation of cardiac muscle contraction / BMP signaling pathway / positive regulation of cardiac muscle cell proliferation / negative regulation of cell migration / kidney development / cytokine activity / growth factor activity / hormone activity / negative regulation of cell growth / Z disc / cell adhesion / positive regulation of gene expression / positive regulation of DNA-templated transcription / cell surface / extracellular space / extracellular region / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å | ||||||
Authors | Guo, J. / Yu, M. / Li, W. | ||||||
Funding support | United Kingdom, 1items
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Citation | Journal: Nat Commun / Year: 2022 Title: Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Authors: Guo, J. / Liu, B. / Thorikay, M. / Yu, M. / Li, X. / Tong, Z. / Salmon, R.M. / Read, R.J. / Ten Dijke, P. / Morrell, N.W. / Li, W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7poj.cif.gz | 261.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7poj.ent.gz | 177.4 KB | Display | PDB format |
PDBx/mmJSON format | 7poj.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7poj_validation.pdf.gz | 479.1 KB | Display | wwPDB validaton report |
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Full document | 7poj_full_validation.pdf.gz | 483.7 KB | Display | |
Data in XML | 7poj_validation.xml.gz | 18.9 KB | Display | |
Data in CIF | 7poj_validation.cif.gz | 24.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/po/7poj ftp://data.pdbj.org/pub/pdb/validation_reports/po/7poj | HTTPS FTP |
-Related structure data
Related structure data | 7poiSC 7ppaC 7ppbC 7ppcC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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