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- PDB-7n2o: AS4.2-YEIH-HLA*B27 -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 7n2o
TitleAS4.2-YEIH-HLA*B27
Components
  • (T-cell receptor ...) x 2
  • Beta-2-microglobulinBeta-2 microglobulin
  • Human leukocyte antigen (HLA) B27
  • YeiH protein
KeywordsIMMUNE SYSTEM / TCR MHC HLA-B27
Function / homology
Function and homology information


antigen processing and presentation of peptide antigen via MHC class I / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / negative regulation of receptor binding / lumenal side of endoplasmic reticulum membrane / Endosomal/Vacuolar pathway ...antigen processing and presentation of peptide antigen via MHC class I / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / negative regulation of receptor binding / lumenal side of endoplasmic reticulum membrane / Endosomal/Vacuolar pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / cellular response to iron(III) ion / negative regulation of forebrain neuron differentiation / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / response to molecule of bacterial origin / regulation of erythrocyte differentiation / regulation of iron ion transport / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / cellular response to iron ion / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / positive regulation of T cell mediated cytotoxicity / peptide antigen assembly with MHC class II protein complex / negative regulation of neurogenesis / MHC class II protein complex / positive regulation of receptor-mediated endocytosis / cellular response to nicotine / recycling endosome membrane / phagocytic vesicle membrane / specific granule lumen / peptide antigen binding / positive regulation of cellular senescence / antigen processing and presentation of exogenous peptide antigen via MHC class II / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of immune response / negative regulation of epithelial cell proliferation / Interferon gamma signaling / positive regulation of T cell activation / Modulation by Mtb of host immune system / sensory perception of smell / negative regulation of neuron projection development / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / late endosome membrane / T cell differentiation in thymus / positive regulation of protein binding / ER-Phagosome pathway / iron ion transport / protein refolding / early endosome membrane / protein homotetramerization / intracellular iron ion homeostasis / amyloid fibril formation / learning or memory / Amyloid fiber formation / lysosomal membrane / external side of plasma membrane / endoplasmic reticulum lumen / Golgi membrane / focal adhesion / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / membrane / identical protein binding / plasma membrane / cytosol
Similarity search - Function
MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set ...MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
MHC class I antigen / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å
AuthorsYang, X. / Jude, K.M. / Garcia, K.C.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)5R01AI103867 United States
CitationJournal: Nature / Year: 2022
Title: Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Authors: Yang, X. / Garner, L.I. / Zvyagin, I.V. / Paley, M.A. / Komech, E.A. / Jude, K.M. / Zhao, X. / Fernandes, R.A. / Hassman, L.M. / Paley, G.L. / Savvides, C.S. / Brackenridge, S. / Quastel, M. ...Authors: Yang, X. / Garner, L.I. / Zvyagin, I.V. / Paley, M.A. / Komech, E.A. / Jude, K.M. / Zhao, X. / Fernandes, R.A. / Hassman, L.M. / Paley, G.L. / Savvides, C.S. / Brackenridge, S. / Quastel, M.N. / Chudakov, D.M. / Bowness, P. / Yokoyama, W.M. / McMichael, A.J. / Gillespie, G.M. / Garcia, K.C.
History
DepositionMay 29, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 7, 2022Provider: repository / Type: Initial release
Revision 1.1Dec 21, 2022Group: Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
Revision 1.2Jan 4, 2023Group: Database references / Category: citation
Item: _citation.journal_volume / _citation.page_first / _citation.page_last
Revision 1.3Oct 25, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
C: YeiH protein
A: Human leukocyte antigen (HLA) B27
B: Beta-2-microglobulin
D: T-cell receptor alpha chain
F: T-cell receptor beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)96,07210
Polymers95,2245
Non-polymers8485
Water1,08160
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area11890 Å2
ΔGint-42 kcal/mol
Surface area38910 Å2
MethodPISA
Unit cell
Length a, b, c (Å)54.832, 95.999, 180.481
Angle α, β, γ (deg.)90.000, 90.000, 90.000
Int Tables number19
Space group name H-MP212121
Space group name HallP2ac2ab
Symmetry operation#1: x,y,z
#2: x+1/2,-y+1/2,-z
#3: -x,y+1/2,-z+1/2
#4: -x+1/2,-y,z+1/2

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Components

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Protein , 2 types, 2 molecules AB

#2: Protein Human leukocyte antigen (HLA) B27 / HLA-B27


Mass: 32086.250 Da / Num. of mol.: 1 / Mutation: C67S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Escherichia coli (E. coli) / References: UniProt: A3F718
#3: Protein Beta-2-microglobulin / Beta-2 microglobulin


Mass: 11879.356 Da / Num. of mol.: 1 / Fragment: UNP residues 21-119
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Escherichia coli (E. coli) / References: UniProt: P61769

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T-cell receptor ... , 2 types, 2 molecules DF

#4: Protein T-cell receptor alpha chain


Mass: 22869.102 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#5: Protein T-cell receptor beta chain


Mass: 27311.295 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)

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Protein/peptide / Sugars , 2 types, 4 molecules C

#1: Protein/peptide YeiH protein


Mass: 1078.413 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human)
#7: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 2 types, 62 molecules

#6: Chemical ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol


Mass: 92.094 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C3H8O3
#8: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 60 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.51 Å3/Da / Density % sol: 50.9 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop / Details: 20% PEG3350 with 0.2M Ammonium acetate

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Data collection

DiffractionMean temperature: 80 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SSRL / Beamline: BL12-1 / Wavelength: 0.97946 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Feb 28, 2020
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97946 Å / Relative weight: 1
ReflectionResolution: 2.3→42.38 Å / Num. obs: 42906 / % possible obs: 99.5 % / Redundancy: 9.6 % / Biso Wilson estimate: 50.25 Å2 / CC1/2: 0.992 / Net I/σ(I): 6.5
Reflection shellResolution: 2.3→2.38 Å / Num. unique obs: 3962 / CC1/2: 0.175

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Processing

Software
NameVersionClassification
PHENIX1.20.1_4487refinement
PHENIX1.20.1_4487refinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 5KSB, 1JGE

5ksb

1jge


Resolution: 2.3→42.38 Å / SU ML: 0.4201 / Cross valid method: FREE R-VALUE / σ(F): 1.33 / Phase error: 31.5542
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2669 1994 4.67 %
Rwork0.2212 40686 -
obs0.2233 42680 99.15 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 61.24 Å2
Refinement stepCycle: LAST / Resolution: 2.3→42.38 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6624 0 54 60 6738
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00186840
X-RAY DIFFRACTIONf_angle_d0.46389295
X-RAY DIFFRACTIONf_chiral_restr0.03941003
X-RAY DIFFRACTIONf_plane_restr0.00371220
X-RAY DIFFRACTIONf_dihedral_angle_d12.94012510
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.3-2.360.38721270.37452591X-RAY DIFFRACTION90.69
2.36-2.420.40251400.3592846X-RAY DIFFRACTION99.17
2.42-2.50.35561420.33932909X-RAY DIFFRACTION99.87
2.5-2.580.38141410.33632880X-RAY DIFFRACTION99.8
2.58-2.670.37131420.32712874X-RAY DIFFRACTION99.93
2.67-2.780.35971420.3122921X-RAY DIFFRACTION99.93
2.78-2.90.33761440.29382914X-RAY DIFFRACTION99.9
2.9-3.050.31771410.27592896X-RAY DIFFRACTION99.9
3.05-3.250.32171440.26682926X-RAY DIFFRACTION99.93
3.25-3.50.30771410.23752895X-RAY DIFFRACTION99.7
3.5-3.850.24141450.20282964X-RAY DIFFRACTION99.97
3.85-4.40.19811450.17022953X-RAY DIFFRACTION99.9
4.4-5.550.19071460.14812998X-RAY DIFFRACTION99.87
5.55-42.380.23281540.17143119X-RAY DIFFRACTION99.33
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
10.1506253923590.10443016396-0.0928600825970.0593764971937-0.0172714905335-0.01577861145950.0164080943110.0351299409190.1638025856220.173590097399-0.1303543742-0.230546817139-0.2295981275760.370716209248-8.06364358556E-50.3861092175160.043505705775-0.01672372349080.3111420538620.01955900929610.3407836132466.90981973604-2.5214534258355.9657718273
21.0840043068-0.803823727901-0.3199821706411.40169428971-0.211307471945-0.374191647645-0.106643067495-0.111929840627-0.0942968817480.1807082175650.01464336411070.0657892431185-0.0221439664276-0.0978416080626-2.15257854818E-50.33433027437-0.000141562335799-0.02294848097530.328139157708-0.00228233376310.32017404032312.5270436852-5.0839457191863.1433798892
30.6599084211520.1151498088850.7774527999310.6362204252750.217778364560.619319382102-0.1813133650050.1415137496880.388280400674-0.09042038587810.0765873023759-0.02814951225810.130418439324-0.113641945886-0.00803290630630.2549061003420.0295748850904-0.01853822841620.1901762220450.05205751701270.36176471017212.04707359175.0859889081254.1971674873
40.94695410554-0.5859561277840.4560379197730.254086863036-0.6758374479891.32154022883-0.0238378891272-0.1424952052570.3213522867790.135903807859-0.09410466588540.0602023053351-0.08106122299570.246266763799-0.002172640991280.426990967483-0.0165516228824-0.08154091384930.458656079881-0.07142061763720.39926857347436.6070629779.6743494238183.3093289546
5-0.01378291007440.125269370780.1131962059870.1134726164760.1775325806190.12307204848-0.2006376324690.3082583278960.1314001100940.02901145284380.146903102407-0.0057894602450.2540371502080.546013005380.0002207706062340.4462749257510.0073549847643-0.09393876878340.4879568565510.08097632893620.47868497861333.4846131967-7.810112809869.6445586288
60.6106063165551.53006046801-0.3329752445513.73238341846-0.8278712239660.1868865223680.225438287161-0.1247563193220.100845531330.3635205541410.2446934011690.385044760155-0.06371616682050.1399385250890.2962932454731.034150361130.144460195068-0.1561369712250.84978978638-0.1074623414980.31820650870428.8018878708-4.9391117288894.2757115568
7-0.027693288692-0.01164628530070.008832619716170.190742572660.1187183322350.05449434858550.103675174647-0.133568087106-0.0831341732518-0.02130897733390.160175674085-0.388545687034-0.165587243782-0.4441804140780.0005283790405560.5855872879230.0872974493635-0.1328892274090.513014497214-0.00433711977490.40065662966328.2685005628-7.9531495118979.7411154024
81.023498997030.08930658351850.1993832616210.0277253805297-0.1485206134610.7160977577320.1799172273310.266624426863-0.6061352439780.01580209555040.554079160020.01446069630090.491989056571-0.184413483652-0.1123363067030.5021844884030.0544759625832-0.2202327124360.4179616548350.09401928498460.52343065083829.6248384174-16.19766290572.8853787943
90.02594899835850.0597374920180.01538370239360.1748654316750.1059709694820.105062813235-0.0588430727879-0.0391285170914-1.005420380720.1859029980190.4118844842620.212504483309-0.2732532799090.315916130293-0.000723863796810.7127871770120.0230063624667-0.145765451480.7073101541040.02682973880810.47678456969726.6244851746-19.725527675983.3672571727
10-0.01286484679360.06860870229530.1023613649860.07135733976150.04966852001240.119382001249-0.2002772831150.0169100227533-0.02281307543520.3464728213670.22234657669-0.233943316544-0.1937605628730.301336250907-0.007907427375940.5645258327880.0473564575525-0.1136480629810.4314043969480.03320706459760.45787816745824.2584927109-7.0500247009273.3918595767
110.01795978200690.122025369052-0.07122522231161.23158429569-0.5563210849750.285554855487-0.15784167861-0.2546728722670.655143312549-0.0186214821869-0.20308960569-0.4959321754230.009978080644820.0766532640896-0.05847572920181.17940020485-0.0211347193169-0.4305913514921.10028478887-0.03582352352630.67142518432636.7914647101-14.617320658294.925704404
120.0352684682789-0.05767685101730.02739173612130.0855470866685-0.09091199843250.07439626199310.0588308096579-0.0678496691017-0.714644455331-0.274247763109-0.1325890781830.2593760765110.745313291589-0.207934122246-0.0001457901334590.6034885168260.11945444433-0.1758288446450.502157192777-0.01970371026180.57279577240536.071029379-16.852801858772.7044273998
130.172436903108-0.328475125828-0.3080951996050.7818619771510.5188678126670.5353170084440.525675041981-0.965473228939-0.111048010613-0.4321235554740.01294602083-0.230920699744-0.6434345613950.1795888744430.02477240237910.618617923025-0.0248578034812-0.218373677730.6299719332-0.07156574075040.50670511988238.7191918345-8.8105280205584.2747740672
141.46474345975-0.200448123179-0.05832459872211.45005191823-0.3633349358971.18567640283-0.0767347088733-0.1978128603790.1737823530290.06773330733980.05693546979290.0627169927897-0.0926626327475-0.04527138956782.86728339722E-50.299319962850.0119287430801-0.02041357361530.2646847463350.03072416083440.344408620142-12.89234924656.8868746971547.2171926568
150.0658157584082-0.00652346446064-0.1290321817910.0663122982432-0.03315835169740.1457746674950.169564863119-0.2934790630320.146963675490.3159388313640.0484018472346-0.318725543274-0.02581126964660.04525020569836.58026526551E-60.501178994469-0.00558396685791-0.07448189490950.451272530506-0.0580550058190.416696662065-9.07590311674-8.4057003038852.5896331972
160.2430407230910.35079020487-0.156491354970.210023912393-0.3162498008240.583030658309-0.08578030230780.3496289999740.301352389329-0.117526948813-0.0556420505863-0.04719892732840.1846445277590.126133380509-0.0002638944121360.3979112699760.00473348128487-0.0786482273140.4130154338180.1001409041720.401929779356-33.991141177313.011792066523.9748495867
170.358406813865-0.4810951436480.1954918563620.6234692686250.101804505080.9938888594940.2443263119880.06710571552970.1660338554880.18425377031-0.07721424518940.258792906054-0.218164056709-0.07939315067063.72854558576E-50.591838487698-0.0051092173806-0.03280631944870.6513883891670.00588816460810.580104027346-40.155677861410.733543447325.243452463
180.8234512123570.3270441293970.2113578792930.823661798932-0.359263937871.034766061720.02560041868390.182298927706-0.141105566375-0.0445730461620.0129349051772-0.1525365419260.1257717238720.1215017695347.48752056178E-60.3251252113290.0113954518399-0.0002528775913580.340301223751-0.04526231988220.408577566286-9.56787862916-14.764746982838.8082568344
190.189345605231-0.08807408742280.1358811310330.09599906463090.01262383538240.348310533495-0.0691753971687-0.188946255220.158356821366-0.123382113595-0.233407101775-0.0953809099159-0.222142622253-0.658912943918-0.002256174357340.37738812689-0.140246055902-0.04736987254370.389892158065-0.05768526346730.336632625036-29.3490686577-18.444796300828.7693649906
200.4410465736760.204056572036-0.1338176263260.145647771437-0.05755317939310.112479933190.03648046439530.08934798344510.082843301524-0.230107052164-0.157518250194-0.0192700308752-0.2164378997990.4521988903971.36196513696E-50.426459779904-0.0437733151063-0.06231522537720.6087339543820.04428632843710.402462295805-32.66641747783.1505861754716.5680935139
210.124207438748-0.3601399677390.00947964040850.652984825714-0.1587718239980.0485190355358-0.007399218309070.0199637443764-0.2863227451250.53485754877-0.1227692266740.0845032317017-0.3669519433070.114367498964-6.34612723943E-50.587446104469-0.07306497806690.003243307910590.7995514743820.003825623767590.514551350126-31.4117510847-2.6603645548524.5513430873
220.603105462165-0.9209796106210.2815996466110.608542198806-0.8315902417090.227291112502-0.04794681319390.345093720287-0.00106576022938-0.2379564320770.04821964489910.1124399654680.1254914858180.22325692359-4.52645447226E-60.577300507439-0.0264714658211-0.04869956350760.5488450257830.004153550088790.372620421388-28.9377035092-4.9849262255613.8981328215
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'C' and (resid 1 through 9 )CA1 - 91 - 9
22chain 'A' and (resid 1 through 118 )AB1 - 1181 - 118
33chain 'A' and (resid 119 through 174 )AB119 - 174119 - 174
44chain 'A' and (resid 175 through 276 )AB175 - 276175 - 276
55chain 'B' and (resid 0 through 11 )BC0 - 111 - 12
66chain 'B' and (resid 12 through 19 )BC12 - 1913 - 20
77chain 'B' and (resid 20 through 30 )BC20 - 3021 - 31
88chain 'B' and (resid 31 through 41 )BC31 - 4132 - 42
99chain 'B' and (resid 42 through 51 )BC42 - 5143 - 52
1010chain 'B' and (resid 52 through 71 )BC52 - 7153 - 72
1111chain 'B' and (resid 72 through 77 )BC72 - 7773 - 78
1212chain 'B' and (resid 78 through 90 )BC78 - 9079 - 91
1313chain 'B' and (resid 91 through 99 )BC91 - 9992 - 100
1414chain 'D' and (resid 2 through 96 )DD2 - 961 - 95
1515chain 'D' and (resid 97 through 110 )DD97 - 11096 - 109
1616chain 'D' and (resid 111 through 133)DD111 - 133110 - 132
1717chain 'D' and (resid 138 through 207 )DD138 - 207133 - 202
1818chain 'F' and (resid 3 through 108 )FG3 - 1081 - 106
1919chain 'F' and (resid 109 through 123 )FG109 - 123107 - 121
2020chain 'F' and (resid 124 through 161 )FG124 - 161122 - 159
2121chain 'F' and (resid 162 through 187 )FG162 - 187160 - 185
2222chain 'F' and (resid 188 through 243 )FG188 - 243186 - 241

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