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- PDB-7n2n: TCR-antigen complex AS4.2-PRPF3-HLA*B27 -

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Basic information

Entry
Database: PDB / ID: 7n2n
TitleTCR-antigen complex AS4.2-PRPF3-HLA*B27
Components
  • (T cell receptor ...T-cell receptor) x 2
  • Beta-2-microglobulinBeta-2 microglobulin
  • Human leukocyte antigen (HLA) B27
  • Pre-MRNA Processing Factor 3
KeywordsIMMUNE SYSTEM / TCR MHC HLA-B27
Function / homology
Function and homology information


antigen processing and presentation of peptide antigen via MHC class I / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / negative regulation of receptor binding / lumenal side of endoplasmic reticulum membrane / Endosomal/Vacuolar pathway ...antigen processing and presentation of peptide antigen via MHC class I / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / negative regulation of receptor binding / lumenal side of endoplasmic reticulum membrane / Endosomal/Vacuolar pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / cellular response to iron(III) ion / negative regulation of forebrain neuron differentiation / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / response to molecule of bacterial origin / regulation of erythrocyte differentiation / regulation of iron ion transport / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / cellular response to iron ion / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / positive regulation of T cell mediated cytotoxicity / peptide antigen assembly with MHC class II protein complex / negative regulation of neurogenesis / MHC class II protein complex / positive regulation of receptor-mediated endocytosis / cellular response to nicotine / recycling endosome membrane / phagocytic vesicle membrane / specific granule lumen / peptide antigen binding / positive regulation of cellular senescence / antigen processing and presentation of exogenous peptide antigen via MHC class II / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of immune response / negative regulation of epithelial cell proliferation / Interferon gamma signaling / positive regulation of T cell activation / Modulation by Mtb of host immune system / sensory perception of smell / negative regulation of neuron projection development / tertiary granule lumen / DAP12 signaling / MHC class II protein complex binding / late endosome membrane / T cell differentiation in thymus / positive regulation of protein binding / ER-Phagosome pathway / iron ion transport / protein refolding / early endosome membrane / protein homotetramerization / intracellular iron ion homeostasis / amyloid fibril formation / learning or memory / Amyloid fiber formation / lysosomal membrane / external side of plasma membrane / endoplasmic reticulum lumen / Golgi membrane / focal adhesion / Neutrophil degranulation / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / Golgi apparatus / endoplasmic reticulum / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / membrane / identical protein binding / plasma membrane / cytosol
Similarity search - Function
MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set ...MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
MHC class I antigen / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.6 Å
AuthorsYang, X. / Jude, K.M. / Garcia, K.C.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)5R01AI103867 United States
CitationJournal: Nature / Year: 2022
Title: Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides.
Authors: Yang, X. / Garner, L.I. / Zvyagin, I.V. / Paley, M.A. / Komech, E.A. / Jude, K.M. / Zhao, X. / Fernandes, R.A. / Hassman, L.M. / Paley, G.L. / Savvides, C.S. / Brackenridge, S. / Quastel, M. ...Authors: Yang, X. / Garner, L.I. / Zvyagin, I.V. / Paley, M.A. / Komech, E.A. / Jude, K.M. / Zhao, X. / Fernandes, R.A. / Hassman, L.M. / Paley, G.L. / Savvides, C.S. / Brackenridge, S. / Quastel, M.N. / Chudakov, D.M. / Bowness, P. / Yokoyama, W.M. / McMichael, A.J. / Gillespie, G.M. / Garcia, K.C.
History
DepositionMay 29, 2021Deposition site: RCSB / Processing site: RCSB
Revision 1.0Dec 7, 2022Provider: repository / Type: Initial release
Revision 1.1Dec 21, 2022Group: Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
Revision 1.2Jan 4, 2023Group: Database references / Category: citation
Item: _citation.journal_volume / _citation.page_first / _citation.page_last
Revision 1.3Oct 25, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
C: Pre-MRNA Processing Factor 3
A: Human leukocyte antigen (HLA) B27
B: Beta-2-microglobulin
D: T cell receptor alpha chain
F: T cell receptor beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)96,25813
Polymers95,1305
Non-polymers1,1288
Water1,18966
1


  • Idetical with deposited unit
  • defined by author
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)83.109, 53.154, 106.818
Angle α, β, γ (deg.)90.000, 98.485, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z

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Components

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Protein , 2 types, 2 molecules AB

#2: Protein Human leukocyte antigen (HLA) B27 / HLA-B27


Mass: 32086.250 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-B / Production host: Escherichia coli (E. coli) / References: UniProt: A3F718
#3: Protein Beta-2-microglobulin / Beta-2 microglobulin


Mass: 11879.356 Da / Num. of mol.: 1 / Fragment: UNP residues 21-119
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Production host: Escherichia coli (E. coli) / References: UniProt: P61769

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T cell receptor ... , 2 types, 2 molecules DF

#4: Protein T cell receptor alpha chain


Mass: 22869.102 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)
#5: Protein T cell receptor beta chain


Mass: 27311.295 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Production host: Homo sapiens (human)

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Protein/peptide / Sugars , 2 types, 4 molecules C

#1: Protein/peptide Pre-MRNA Processing Factor 3


Mass: 984.236 Da / Num. of mol.: 1 / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human)
#7: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE / N-Acetylglucosamine


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 3 types, 71 molecules

#6: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol


Mass: 92.094 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C3H8O3
#8: Chemical ChemComp-SO4 / SULFATE ION / Sulfate


Mass: 96.063 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: SO4
#9: Water ChemComp-HOH / water / Water


Mass: 18.015 Da / Num. of mol.: 66 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.48 Å3/Da / Density % sol: 50.38 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop
Details: 20% PEG3350 with 0.2M Potassium phosphate monobasic

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Data collection

DiffractionMean temperature: 80 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SSRL / Beamline: BL12-1 / Wavelength: 1.03317 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Feb 28, 2020
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.03317 Å / Relative weight: 1
ReflectionResolution: 2→47.76 Å / Num. obs: 59379 / % possible obs: 94.2 % / Redundancy: 3.4 % / Biso Wilson estimate: 38.13 Å2 / CC1/2: 0.994 / Net I/σ(I): 7
Reflection shellResolution: 2→2.05 Å / Num. unique obs: 3273 / CC1/2: 0.23

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Processing

Software
NameVersionClassification
PHENIX1.19.1_4122+SVNrefinement
XDSdata reduction
XDSdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 5KSB 1JGE

5ksb

1jge


Resolution: 2.6→47.48 Å / SU ML: 0.4078 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 32.5813
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2907 931 3.37 %
Rwork0.2481 26680 -
obs0.2495 27611 95.89 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 48.27 Å2
Refinement stepCycle: LAST / Resolution: 2.6→47.48 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6557 0 71 66 6694
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00196788
X-RAY DIFFRACTIONf_angle_d0.44949222
X-RAY DIFFRACTIONf_chiral_restr0.0395998
X-RAY DIFFRACTIONf_plane_restr0.00371209
X-RAY DIFFRACTIONf_dihedral_angle_d11.97252493
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.6-2.740.33941330.28483812X-RAY DIFFRACTION97.55
2.74-2.910.36451350.29713853X-RAY DIFFRACTION97.51
2.91-3.130.40631290.30213712X-RAY DIFFRACTION94.47
3.13-3.450.33751340.27763821X-RAY DIFFRACTION96.63
3.45-3.950.28591290.25193725X-RAY DIFFRACTION93.52
3.95-4.970.23691350.20843875X-RAY DIFFRACTION96.95
4.97-47.480.23431360.2163882X-RAY DIFFRACTION94.65
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
13.20990680852-1.10226264507-0.6989042180330.413454268034-0.1936449411755.196442225080.101542953913-0.128194663570.2768058111210.3069912186830.1724533338860.6825214174110.3836119601510.398542430698-0.06033470077510.193795453228-0.004947749054930.06914803180020.196150698983-0.002029597423440.24311371063229.193953895-9.269527055457.69106221004
23.429676056980.0805833593697-0.5785629854651.8613248731-1.229647033811.58001406611-0.0160132175797-0.0493590001088-0.1265224474450.2644256848880.05629072011140.496422290887-0.263947902897-0.192058893558-0.08615531935120.169202112805-0.002133738919540.09294337780140.263079455961-0.04403755913220.40375320101920.181452483-8.765760473723.42049272136
31.571711671840.172061826671-0.3626915988094.91384027565-5.913549590247.210415497680.3539436920570.409645368481-0.731578566026-0.892074269435-0.2917772542851.371781715150.9048496579920.744903009457-0.1296558441970.1756414505150.009234204529920.005952667814740.290043892281-0.0911918742740.533367023230.8261982809-21.7667155771-0.701036930819
43.132441017450.97692478979-1.193001152133.02210920293-0.593951601112.116955892490.0109772826667-0.252731544691-0.2510996256220.0735982420516-0.101086769617-0.234622996557-0.001264608414420.1709027934370.05526303139630.1244939419290.04925720856280.02865145979290.147564732772-0.01633923489490.16856878738234.1216397894-15.18589591972.89252839365
52.360424880331.048807439810.9324969433162.009810811460.01962554978024.811298931530.1181375468730.426496173965-0.492446458028-0.5693117153360.04910384221480.06826372360630.817766816950.248457943971-0.1416600261590.4552033821280.02359785697620.0113169727770.398871850225-0.1989213935870.6239853541128.6738552383-33.0279505001-20.1940092712
63.3937673453-0.3313630201410.5127622483312.8200147237-0.01044895019912.496389850590.2151251231410.07597239626890.385163710931-0.6913869432160.01098674751950.604645751336-0.4290872353010.138781700439-0.282496425019-0.35797869357-0.3181448511060.1817475417440.335140714887-0.1239600474970.3815204059685.46216773812-15.6893598302-14.4552261829
72.302471569880.7330679538250.9682257599771.9193560768-0.5356436567132.75718691634-0.3308616387810.0337166821630.0210017495768-0.06740017656860.1011858516890.413778558614-0.142035200118-0.4196344519970.16020041660.2364955446610.02445881415480.08427249354340.327563227353-0.05408594530390.3640084010174.36478190176-10.2529738968-11.2281584277
85.46807197961.08758182434-0.810538382240.872954195411-1.685038770833.315587799030.4562969717670.4938194704550.9951520274440.226423251849-0.1441237715090.705216359859-0.405105547369-0.09866635711980.09634965758770.150453586808-0.0375412114356-0.1470471997440.4022567781460.03197440318850.3973573043653.70472816405-9.39248094591-20.854896047
96.28749826439-2.400752511743.589567224022.86464489408-0.4222957065445.36180221225-0.549462140918-0.777952927266-0.7775691344040.9750345530560.711686108170.711229849862-0.12897810444-0.503142380480.02755262701830.382024633765-0.0159541868290.1779887617250.4258599504510.03673592993210.38885530826928.5491374649-10.309605567131.8694852733
100.508877908898-0.3001275973-0.4153428385510.4286841526550.562849477120.739247592552-0.0187995456596-0.255359141246-0.1471167428690.7594724989510.207944245124-0.2012310207110.1220501937370.2071846719780.1016310696830.9921683458730.127554258038-0.2642631241390.221646546501-0.0970147651014-0.10921634156947.8459798656-18.040864007640.5121551307
112.24338032419-0.04649807057260.8591839003133.41436216215-0.9636060097443.12427131395-0.01867941575930.4319632418350.04441076968230.279429745977-0.001391624371760.04474065427250.114205972585-0.04022276963230.08673274954660.2820496367130.04396868145560.06829202599830.3657977274540.03953513517290.26354103724635.7659983913-12.16841280226.8477384248
127.93108017856-4.610881852280.2530837950814.176110778082.817449154695.87270590024-0.2030225341740.2389991700011.782528266150.3322017828390.429206992858-1.94130830947-2.225259139831.46405289973-0.03508120257230.671726806362-0.2561489489-0.1637576894050.4162620597570.1422552143160.58623114700648.92970711720.59137049273533.2925883116
133.136023060091.407592623470.6633508758047.190347398523.202167001311.83634697072-0.0603199448685-0.0980095405738-0.0969878302297-1.053835772970.587538542375-0.382141482227-0.6418208953620.49690573243-0.4553140855250.340104650784-0.152414873060.07630961553090.417723151192-0.005018203983130.25120224736342.676504323-9.7609746708622.1615232857
149.66176151062-1.760648931986.640051861790.463620090612-1.24974590554.57914743609-0.1885807518580.3085331844810.133203700030.4157937111010.3722457983940.06862736038060.1532193445740.286302132721-0.1109720351340.4825019300090.0733192142926-0.02700443906540.3941595825520.01886665115590.17924986140842.286194719-19.072156178320.1424713602
155.71285906447-0.5043065824172.993469193690.1514185206310.3656956994295.493668094990.35625356483-0.126473362763-0.8198351654971.00524833624-0.0861185845191-0.4099759090320.637891994669-0.110840521316-0.4269552923490.4480543406490.011381052891-0.1627162430810.2331359130330.04619032811020.44801650287537.0403921792-19.654938514726.4463493922
163.01668778802-0.40732416416-0.5598686060610.782627334551-0.6555395800431.042058170440.1432472541690.054128423536-0.09294763605320.917151582020.135150691103-0.478050156279-0.2091084195780.2600992751290.08308917210060.517171368276-0.131942266417-0.2518737912780.257806421511-0.180559801620.40943118340546.8953017139-11.810932307532.9255710071
174.767310604212.61345648278-0.1880524147921.44173552219-0.09837701104260.0157751468390.6708892551941.08120404251.14595426125-0.411434669764-0.04116787180431.55432491057-0.787364818517-0.795567405655-0.3354581366870.4280100712920.2903619095460.1672680341520.9161586426760.1558304170430.9255705497423.2473795336-2.6677102220419.1741760259
185.63950009801-1.185490914533.76897079252.88290360587-2.986429881466.95875768002-0.10804643963-0.6306152749310.5847209423151.029559478410.336370224720.265985501426-0.253573082374-0.1622934110880.1499671819630.5199654443020.00302437314716-0.003007505321920.192075465692-0.04439486291710.30720715326336.1811263037-6.2536697810831.9397831808
194.86856169429-0.6020395921761.497722891193.398990925880.7179890735061.686332400210.5146643245570.360703447795-0.06614084135110.40480783118-0.221000627793-1.205442637180.7791096256510.212523896732-0.1306208237130.9920724055810.0109135743725-0.2720190811150.5645817101140.1636635467050.32472040104360.1126845586-15.704011606946.761880388
205.17175295485-1.010033137191.425924931263.572077999620.9330694298122.37005929703-0.3905681782960.2381670982610.743054191468-0.981711666701-0.280767227848-0.42008309825-0.329125751513-0.2656021990110.3141491945160.7700186684860.226280753996-0.1080121259460.5916925027190.1398434530640.15843051579565.09439499840.92396780931159.4784815912
216.627597295971.510912874660.3068090922635.64887570435-0.4690646653875.19340819420.594761267668-0.26345124905-0.9301569066070.607852071054-0.07447086900990.1385823763270.384089220455-0.271868895024-0.4139556793790.5282121223890.0350298575897-0.09359379178220.6165134554790.1195798377760.51751145802953.4590775314-5.2165530508457.4487356488
225.01972515112-4.14944813757-6.187779119714.015832069315.365063606857.968860651640.5095278230781.2647688370.557427195218-0.322935857096-0.249482984163-1.23737179551.01194315476-0.319615009404-0.312251846440.7234145151230.220150791838-0.1122132226550.5115316211840.07747679276790.57941853682565.4553918937-8.0252186722241.8244482065
232.40757398702-0.4567152718950.8768083179911.08464219218-1.125336246351.22500276577-0.178061647504-0.9195910473560.1056364216240.9704589966580.0275372944011-0.310278245049-0.3865338088880.1786043229640.2535484850661.06871811866-0.196456919733-0.1663210088430.791837947120.1810691445120.51994705318458.4944196348-1.5678346045356.5341257791
242.244639468284.072875922841.486995288177.432425842142.698133413660.978115110372-0.701044803917-0.7046043844920.2731166741861.416509309380.464237459135-0.931359335571-0.182875523857-0.3317675720570.1550591247681.056104076110.127206205885-0.3349189402390.682924642544-0.02280202500180.68646535774554.2840042309-8.8359215340863.8047449228
254.34947257620.08036125694532.734690917464.236515700161.196634436662.735233388660.118382202442-0.450913818473-0.1907658792850.8805803161120.09161776080890.0384655513635-0.0991449482496-0.352471406962-0.3217146131781.206279093050.206102214142-0.1850209900710.8682174747270.3470201688650.35457287334364.3870562693-12.217482541264.0697643123
260.984962914417-0.2632064503690.854930454932.648525689192.052834779623.94874227180.0155050574033-0.0593228593750.01916625568430.213189192174-0.08224305240430.0333085689358-0.227676269888-0.2161980550540.09525824409060.2387055246110.01178454842010.04624173628720.1846888673850.02367333662760.20179370513136.797750975110.340612423627.5299905292
274.30757528167-2.966095015010.1468111288723.57283882504-0.6278021617811.15656035641-0.402512019436-0.3450642262260.1066664747990.3920710734730.289368828543-0.247674171198-0.2944479478130.04592702311920.06622817490620.499932376178-0.0400068094223-0.1270579226430.3561237639290.008574273809340.37619838357258.84174565039.5725037628247.7897701641
Refinement TLS group

Refine-ID: X-RAY DIFFRACTION

IDRefine TLS-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11chain 'C' and (resid 1 through 9 )CA1 - 91 - 9
22chain 'A' and (resid 1 through 103 )AB1 - 1031 - 103
33chain 'A' and (resid 104 through 118 )AB104 - 118104 - 118
44chain 'A' and (resid 119 through 174 )AB119 - 174119 - 174
55chain 'A' and (resid 175 through 275 )AB175 - 275175 - 275
66chain 'B' and (resid 0 through 30 )BC0 - 301 - 31
77chain 'B' and (resid 31 through 77 )BC31 - 7732 - 78
88chain 'B' and (resid 78 through 99 )BC78 - 9979 - 100
99chain 'D' and (resid 2 through 8 )DF2 - 81 - 7
1010chain 'D' and (resid 9 through 19 )DF9 - 198 - 18
1111chain 'D' and (resid 20 through 39 )DF20 - 3919 - 38
1212chain 'D' and (resid 40 through 44 )DF40 - 4439 - 43
1313chain 'D' and (resid 45 through 52 )DF45 - 5244 - 51
1414chain 'D' and (resid 53 through 62 )DF53 - 6252 - 61
1515chain 'D' and (resid 63 through 78 )DF63 - 7862 - 77
1616chain 'D' and (resid 79 through 93 )DF79 - 9378 - 92
1717chain 'D' and (resid 94 through 103 )DF94 - 10393 - 102
1818chain 'D' and (resid 104 through 113 )DF104 - 113103 - 112
1919chain 'D' and (resid 114 through 123 )DF114 - 123113 - 122
2020chain 'D' and (resid 124 through 132 )DF124 - 132123 - 131
2121chain 'D' and (resid 139 through 164 )DF139 - 164132 - 157
2222chain 'D' and (resid 165 through 173 )DF165 - 173158 - 166
2323chain 'D' and (resid 174 through 190 )DF174 - 190167 - 180
2424chain 'D' and (resid 191 through 200 )DF191 - 200181 - 190
2525chain 'D' and (resid 201 through 206 )DF201 - 206191 - 196
2626chain 'F' and (resid 3 through 123 )FJ3 - 1231 - 121
2727chain 'F' and (resid 124 through 243 )FJ124 - 243122 - 241

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