登録情報 | データベース: PDB / ID: 7mk5 |
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タイトル | Crystal structure of Escherichia coli ClpP covalently inhibited by clipibicyclene |
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要素 | ATP-dependent Clp protease proteolytic subunit |
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キーワード | HYDROLASE/HYDROLASE inhibitor / Inhibitor / Complex / Protease / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex |
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機能・相同性 | 機能・相同性情報
HslUV protease complex / endopeptidase Clp / endopeptidase Clp complex / positive regulation of programmed cell death / response to temperature stimulus / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / proteasomal protein catabolic process / serine-type peptidase activity / response to radiation ...HslUV protease complex / endopeptidase Clp / endopeptidase Clp complex / positive regulation of programmed cell death / response to temperature stimulus / ATP-dependent peptidase activity / protein quality control for misfolded or incompletely synthesized proteins / proteasomal protein catabolic process / serine-type peptidase activity / response to radiation / ATPase binding / response to heat / serine-type endopeptidase activity / proteolysis / identical protein binding / membrane / cytosol類似検索 - 分子機能 ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / 2-enoyl-CoA Hydratase; Chain A, domain 1 / 2-enoyl-CoA Hydratase; Chain A, domain 1 / ClpP/crotonase-like domain superfamily ...ClpP, Ser active site / Endopeptidase Clp serine active site. / ClpP, histidine active site / Endopeptidase Clp histidine active site. / ATP-dependent Clp protease proteolytic subunit / Clp protease proteolytic subunit /Translocation-enhancing protein TepA / Clp protease / 2-enoyl-CoA Hydratase; Chain A, domain 1 / 2-enoyl-CoA Hydratase; Chain A, domain 1 / ClpP/crotonase-like domain superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 ACETATE ION / Chem-ZGV / ATP-dependent Clp protease proteolytic subunit類似検索 - 構成要素 |
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生物種 |  Escherichia coli K-12 (大腸菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.95 Å |
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データ登録者 | Culp, E.J. / Sychantha, D. / Hobson, C. / Pawlowski, A.J. / Prehna, G. / Wright, G.D. |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Canadian Institutes of Health Research (CIHR) | FRN-148463 | カナダ |
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引用 | ジャーナル: Nat Microbiol / 年: 2022 タイトル: ClpP inhibitors are produced by a widespread family of bacterial gene clusters. 著者: Culp, E.J. / Sychantha, D. / Hobson, C. / Pawlowski, A.C. / Prehna, G. / Wright, G.D. |
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履歴 | 登録 | 2021年4月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年2月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年11月16日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2024年4月3日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.3 | 2024年10月30日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature Item: _pdbx_entry_details.has_protein_modification |
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