登録情報 データベース : PDB / ID : 7m5z 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the MerTK Kinase Domain in Complex with Inhibitor MIPS15692 要素Tyrosine-protein kinase Mer 詳細 キーワード SIGNALING PROTEIN/INHIBITOR / Kinase / SIGNALING PROTEIN-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of leukocyte apoptotic process / negative regulation of lymphocyte activation / neutrophil clearance / natural killer cell differentiation / secretion by cell / negative regulation of cytokine production / vagina development / photoreceptor outer segment / phagocytosis / positive regulation of phagocytosis ... negative regulation of leukocyte apoptotic process / negative regulation of lymphocyte activation / neutrophil clearance / natural killer cell differentiation / secretion by cell / negative regulation of cytokine production / vagina development / photoreceptor outer segment / phagocytosis / positive regulation of phagocytosis / cell surface receptor protein tyrosine kinase signaling pathway / transmembrane receptor protein tyrosine kinase activity / substrate adhesion-dependent cell spreading / establishment of localization in cell / Cell surface interactions at the vascular wall / receptor protein-tyrosine kinase / platelet activation / cell migration / cell-cell signaling / retina development in camera-type eye / nervous system development / spermatogenesis / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell surface receptor signaling pathway / receptor complex / protein phosphorylation / extracellular space / ATP binding / plasma membrane / cytoplasm 類似検索 - 分子機能 Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain ... Immunoglobulin / Immunoglobulin domain / Immunoglobulin domain / Fibronectin type III domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.06 Å 詳細データ登録者 Hermans, S.J. / Hancock, N.C. / Baell, J.B. / Parker, M.W. 引用ジャーナル : Eur.J.Med.Chem. / 年 : 2021タイトル : Development of [ 18 F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.著者: Wong, S.W. / Vivash, L. / Mudududdla, R. / Nguyen, N. / Hermans, S.J. / Shackleford, D.M. / Field, J. / Xue, L. / Aprico, A. / Hancock, N.C. / Haskali, M. / Stashko, M.A. / Frye, S.V. / Wang, ... 著者 : Wong, S.W. / Vivash, L. / Mudududdla, R. / Nguyen, N. / Hermans, S.J. / Shackleford, D.M. / Field, J. / Xue, L. / Aprico, A. / Hancock, N.C. / Haskali, M. / Stashko, M.A. / Frye, S.V. / Wang, X. / Binder, M.D. / Ackermann, U. / Parker, M.W. / Kilpatrick, T.J. / Baell, J.B. 履歴 登録 2021年3月25日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年10月6日 Provider : repository / タイプ : Initial release改定 1.1 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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