- PDB-7luo: N-terminus of Skp2 bound to Cyclin A -
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Basic information
Entry
Database: PDB / ID: 7luo
Title
N-terminus of Skp2 bound to Cyclin A
Components
S-phase kinase-associated protein 2,Cyclin-A2
Skp2 Motif 1 uncharacterized fragment 1
Skp2 Motif 1 uncharacterized fragment 2
Keywords
CELL CYCLE / Complex / Cyclin / Ligase / Fusion
Function / homology
Function and homology information
positive regulation of protein polyubiquitination / cellular response to cell-matrix adhesion / : / cyclin A2-CDK1 complex / Aberrant regulation of mitotic exit in cancer due to RB1 defects / cell cycle G1/S phase transition / cellular response to luteinizing hormone stimulus / Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 / cellular response to leptin stimulus / male pronucleus ...positive regulation of protein polyubiquitination / cellular response to cell-matrix adhesion / : / cyclin A2-CDK1 complex / Aberrant regulation of mitotic exit in cancer due to RB1 defects / cell cycle G1/S phase transition / cellular response to luteinizing hormone stimulus / Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 / cellular response to leptin stimulus / male pronucleus / female pronucleus / response to glucagon / cellular response to cocaine / cyclin-dependent protein serine/threonine kinase regulator activity / positive regulation of DNA biosynthetic process / SCF ubiquitin ligase complex / cellular response to insulin-like growth factor stimulus / SCF-dependent proteasomal ubiquitin-dependent protein catabolic process / positive regulation of intracellular estrogen receptor signaling pathway / cyclin A2-CDK2 complex / G2 Phase / p53-Dependent G1 DNA Damage Response / microtubule organizing center / Regulation of APC/C activators between G1/S and early anaphase / regulation of DNA replication / G0 and Early G1 / cochlea development / Telomere Extension By Telomerase / protein K63-linked ubiquitination / animal organ regeneration / ubiquitin-like ligase-substrate adaptor activity / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / positive regulation of double-strand break repair via homologous recombination / protein K48-linked ubiquitination / Cyclin A/B1/B2 associated events during G2/M transition / Cyclin A:Cdk2-associated events at S phase entry / cyclin-dependent protein kinase holoenzyme complex / Regulation of BACH1 activity / cellular response to platelet-derived growth factor stimulus / cellular response to nitric oxide / post-translational protein modification / Cdc20:Phospho-APC/C mediated degradation of Cyclin A / APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 / positive regulation of smooth muscle cell proliferation / cellular response to estradiol stimulus / CDK-mediated phosphorylation and removal of Cdc6 / G1/S transition of mitotic cell cycle / SCF(Skp2)-mediated degradation of p27/p21 / DNA Damage/Telomere Stress Induced Senescence / Orc1 removal from chromatin / Cyclin D associated events in G1 / Regulation of RUNX2 expression and activity / positive regulation of fibroblast proliferation / Regulation of TP53 Degradation / G2/M transition of mitotic cell cycle / Antigen processing: Ubiquitination & Proteasome degradation / Neddylation / Processing of DNA double-strand break ends / Senescence-Associated Secretory Phenotype (SASP) / Regulation of TP53 Activity through Phosphorylation / regulation of apoptotic process / cellular response to hypoxia / defense response to virus / proteasome-mediated ubiquitin-dependent protein catabolic process / Ras protein signal transduction / Ub-specific processing proteases / regulation of cell cycle / protein domain specific binding / innate immune response / cell division / DNA-templated transcription / protein kinase binding / positive regulation of DNA-templated transcription / nucleolus / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function