登録情報 | データベース: PDB / ID: 7lbc |
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タイトル | Structure of human GGT1 in complex with Lnt2-65 compound |
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要素 | (Glutathione hydrolase 1 ...) x 2 |
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / substrate-enzyme complex / NTN-hydrolase family / glycoprotein / N-glycosylation / cell surface / HYDROLASE-HYDROLASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
leukotriene-C4 hydrolase / peptidyltransferase activity / leukotriene-C(4) hydrolase / leukotriene D4 biosynthetic process / Defective GGT1 causes GLUTH / Defective GGT1 in aflatoxin detoxification causes GLUTH / LTC4-CYSLTR mediated IL4 production / Glutathione synthesis and recycling / peptide modification / gamma-glutamyltransferase ...leukotriene-C4 hydrolase / peptidyltransferase activity / leukotriene-C(4) hydrolase / leukotriene D4 biosynthetic process / Defective GGT1 causes GLUTH / Defective GGT1 in aflatoxin detoxification causes GLUTH / LTC4-CYSLTR mediated IL4 production / Glutathione synthesis and recycling / peptide modification / gamma-glutamyltransferase / glutathione gamma-glutamate hydrolase / glutathione hydrolase activity / leukotriene C4 gamma-glutamyl transferase activity / glutathione catabolic process / leukotriene metabolic process / glutamate metabolic process / glutathione biosynthetic process / Aflatoxin activation and detoxification / cysteine biosynthetic process / Synthesis of Leukotrienes (LT) and Eoxins (EX) / regulation of immune system process / Paracetamol ADME / amino acid metabolic process / zymogen activation / fatty acid metabolic process / regulation of inflammatory response / spermatogenesis / proteolysis / extracellular space / extracellular exosome / plasma membrane類似検索 - 分子機能 Gamma-glutamyltranspeptidase / Gamma-glutamyltranspeptidase signature. / Gamma-glutamyltranspeptidase / Gamma-glutamyltranspeptidase, large subunit, C-terminal domain / Gamma-glutamyltranspeptidase, small subunit / Nucleophile aminohydrolases, N-terminal類似検索 - ドメイン・相同性 Chem-XSA / Glutathione hydrolase 1 proenzyme類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.28 Å |
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データ登録者 | Terzyan, S.S. / Hanigan, M. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM125952 | 米国 |
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引用 | ジャーナル: Bioorg.Med.Chem. / 年: 2022 タイトル: Design and evaluation of novel analogs of 2-amino-4-boronobutanoic acid (ABBA) as inhibitors of human gamma-glutamyl transpeptidase. 著者: Nguyen, L. / Schultz, D.C. / Terzyan, S.S. / Rezaei, M. / Songb, J. / Li, C. / You, Y. / Hanigan, M.H. |
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履歴 | 登録 | 2021年1月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年2月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月6日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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