Entry Database : PDB / ID : 7kht Structure visualization Downloads & linksTitle The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (SF-1) ComponentsPeroxisome proliferator-activated receptor gamma coactivator 1-alpha peptide Steroidogenic factor 1 DetailsKeywords LIPID BINDING PROTEIN / PI(3 / 4 / 5)P3 acyl chains / acyl chain length / acyl chain induced conformational change / nuclear PIP2 / nuclear PIP3 / nuclear receptorFunction / homology Function and homology informationFunction Domain/homology Component
primary sex determination / Sertoli cell differentiation / negative regulation of female gonad development / Regulation of MITF-M dependent genes involved in metabolism / sex determination / positive regulation of male gonad development / regulation of steroid biosynthetic process / luteinization / Transcriptional regulation of testis differentiation / Transcriptional regulation of pluripotent stem cells ... primary sex determination / Sertoli cell differentiation / negative regulation of female gonad development / Regulation of MITF-M dependent genes involved in metabolism / sex determination / positive regulation of male gonad development / regulation of steroid biosynthetic process / luteinization / Transcriptional regulation of testis differentiation / Transcriptional regulation of pluripotent stem cells / tissue development / positive regulation of fatty acid oxidation / Leydig cell differentiation / male sex determination / maintenance of protein location in nucleus / hormone metabolic process / response to muscle activity / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / cellular respiration / lncRNA binding / adrenal gland development / temperature homeostasis / female gonad development / response to starvation / intracellular glucose homeostasis / fatty acid oxidation / response to dietary excess / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / brown fat cell differentiation / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / energy homeostasis / positive regulation of gluconeogenesis / digestion / hormone-mediated signaling pathway / respiratory electron transport chain / RNA splicing / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / mitochondrion organization / transcription coregulator binding / gluconeogenesis / nuclear receptor binding / transcription initiation at RNA polymerase II promoter / RNA polymerase II transcription regulatory region sequence-specific DNA binding / negative regulation of smooth muscle cell proliferation / transcription coregulator activity / circadian regulation of gene expression / Heme signaling / SUMOylation of intracellular receptors / Transcriptional activation of mitochondrial biogenesis / regulation of circadian rhythm / PPARA activates gene expression / PML body / chromatin DNA binding / phospholipid binding / positive regulation of DNA-binding transcription factor activity / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / mRNA processing / RNA polymerase II transcription regulator complex / Regulation of RUNX2 expression and activity / nuclear receptor activity / male gonad development / sequence-specific double-stranded DNA binding / Circadian Clock / positive regulation of cold-induced thermogenesis / cellular response to oxidative stress / protein-containing complex assembly / DNA-binding transcription factor binding / neuron apoptotic process / negative regulation of neuron apoptotic process / RNA polymerase II-specific DNA-binding transcription factor binding / sequence-specific DNA binding / transcription coactivator activity / protein stabilization / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / ubiquitin protein ligase binding / chromatin binding / regulation of DNA-templated transcription / positive regulation of gene expression / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / nucleoplasm / nucleus / cytosol Similarity search - Function PGC-1alpha, RNA recognition motif / PGC-1 / Nuclear hormone receptor family 5 / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. ... PGC-1alpha, RNA recognition motif / PGC-1 / Nuclear hormone receptor family 5 / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.504 Å DetailsAuthors Blind, R.D. Funding support United States, 4items Details Hide detailsOrganization Grant number Country American Cancer Society RSG-17-063-01 United States National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM138873 United States National Institutes of Health/National Cancer Institute (NIH/NCI) CA243036 United States National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) United States
CitationJournal : J.Lipid Res. / Year : 2021Title : The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1.Authors : Bryant, J.M. / Malabanan, M.M. / Vanderloop, B.H. / Nichols, C.M. / Haratipour, Z. / Poon, K.T. / Sherrod, S.D. / McLean, J.A. / Blind, R.D. History Deposition Oct 22, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 19, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Jun 9, 2021 Group : Database references / Category : citation / Item : _citation.journal_volume / _citation.titleRevision 1.2 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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