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TitleThe acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1.
Journal, issue, pagesJ. Lipid Res., Vol. 62, Page 100081-100081, Year 2021
Publish dateOct 22, 2020 (structure data deposition date)
AuthorsBryant, J.M. / Malabanan, M.M. / Vanderloop, B.H. / Nichols, C.M. / Haratipour, Z. / Poon, K.T. / Sherrod, S.D. / McLean, J.A. / Blind, R.D.
External linksJ. Lipid Res. / PubMed:33933440
MethodsX-ray diffraction
Resolution2.504 Å
Structure data

PDB-7kht:
The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (SF-1)
Method: X-RAY DIFFRACTION / Resolution: 2.504 Å

Chemicals

ChemComp-WES:
(2S)-3-{[(S)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl (9E,9'E)di-octadec-9-enoate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / PI(3 / 4 / 5)P3 acyl chains / acyl chain length / acyl chain induced conformational change / nuclear PIP2 / nuclear PIP3 / nuclear receptor

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