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- PDB-7jyn: Solution NMR structure of human Brd3 ET complexed with NSD3(148-1... -
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Open data
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Basic information
Entry | Database: PDB / ID: 7jyn | ||||||||||||
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Title | Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide | ||||||||||||
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![]() | SIGNALING PROTEIN / Brd3 ET / NSD3 solution NMR / Integrase / extra terminal domain | ||||||||||||
Function / homology | ![]() [histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase / histone H3K4 dimethyltransferase activity / histone H3K27 dimethyltransferase activity / histone H3K27 trimethyltransferase activity / histone H3K36 methyltransferase activity / transcription regulator activator activity / lncRNA binding / histone H3 methyltransferase activity / endodermal cell differentiation ...[histone H3]-lysine4 N-dimethyltransferase / [histone H3]-lysine27 N-dimethyltransferase / histone H3K4 dimethyltransferase activity / histone H3K27 dimethyltransferase activity / histone H3K27 trimethyltransferase activity / histone H3K36 methyltransferase activity / transcription regulator activator activity / lncRNA binding / histone H3 methyltransferase activity / endodermal cell differentiation / protein localization to chromatin / molecular condensate scaffold activity / lysine-acetylated histone binding / PKMTs methylate histone lysines / methylation / chromatin remodeling / chromatin binding / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / metal ion binding Similarity search - Function | ||||||||||||
Biological species | ![]() | ||||||||||||
Method | SOLUTION NMR / distance geometry | ||||||||||||
![]() | Aiyer, S. / Swapna, G.V.T. / Roth, M.J. / Montelione, G.T. | ||||||||||||
Funding support | ![]()
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![]() | ![]() Title: A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins. Authors: Aiyer, S. / Swapna, G.V.T. / Ma, L.C. / Liu, G. / Hao, J. / Chalmers, G. / Jacobs, B.C. / Montelione, G.T. / Roth, M.J. | ||||||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 954.4 KB | Display | ![]() |
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PDB format | ![]() | 814.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 556.3 KB | Display | ![]() |
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Full document | ![]() | 918.2 KB | Display | |
Data in XML | ![]() | 75.2 KB | Display | |
Data in CIF | ![]() | 87.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7jmyC ![]() 7jq8C ![]() 7jyzC C: citing same article ( |
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Similar structure data | |
Other databases |
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein | Mass: 11264.543 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Protein/peptide | Mass: 4329.835 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() References: UniProt: Q9BZ95, Transferases; Transferring one-carbon groups; Methyltransferases |
Has ligand of interest | Y |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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Sample preparation
Details |
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Sample |
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Sample conditions | Details: 20 mM sodium phosphate, 100mM NaCl and 2 mM 2-mercaptoethanol / Ionic strength: 100 mM NaCl mM / Ionic strength err: 0.2 / pH: 7.0 / PH err: 0.05 / Pressure: 1 atm / Pressure err: 0.05 / Temperature: 298 K / Temperature err: 0.1
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-NMR measurement
NMR spectrometer |
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Processing
NMR software |
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Refinement | Method: distance geometry / Software ordinal: 9 | ||||||||||||||||||||||||||||||||||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||||||||||||||||||||||||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 100 / Conformers submitted total number: 20 |