Entry Database : PDB / ID : 7jjq Structure visualization Downloads & linksTitle Human Hemoglobin in Complex with Nitrosoamphetamine Components(Hemoglobin subunit ...) x 2 Details Keywords OXYGEN TRANSPORT / hemoglobin / iron / heme / nitrosoamphetamine / amphetamineFunction / homology Function and homology informationFunction Domain/homology Component
nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ... nitric oxide transport / hemoglobin alpha binding / cellular oxidant detoxification / hemoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / platelet aggregation / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / carbon dioxide transport / Heme signaling / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / response to hydrogen peroxide / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / Chaperone Mediated Autophagy / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol Similarity search - Function Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / : / Globin/Protoglobin / Globin domain profile. / Globin / Globin / Globin-like superfamily Similarity search - Domain/homology PROTOPORPHYRIN IX CONTAINING FE / (2R)-N-hydroxy-1-phenylpropan-2-amine / Hemoglobin subunit beta / Hemoglobin subunit alpha Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.15 Å DetailsAuthors Powell, S.M. / Thomas, L.M. / Richter-Addo, G.B. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Science Foundation (NSF, United States) United States
CitationJournal : J.Inorg.Biochem. / Year : 2020Title : The nitrosoamphetamine metabolite is accommodated in the active site of human hemoglobin: Spectroscopy and crystal structure.Authors : Powell, S.M. / Thomas, L.M. / Richter-Addo, G.B. History Deposition Jul 27, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Nov 11, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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