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- PDB-7f8h: Structure-activity relationship studies of allosteric inhibitors ... -
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Basic information
Entry | Database: PDB / ID: 7f8h | ||||||
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Title | Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase | ||||||
![]() | Eyes absent homolog 2 | ||||||
![]() | TRANSCRIPTION / eya2 / eyes absent protein / phosphatase / transcription coactivator | ||||||
Function / homology | ![]() histone H2AXY142 phosphatase activity / mesodermal cell fate specification / striated muscle tissue development / mitochondrial outer membrane permeabilization / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of DNA repair / extrinsic apoptotic signaling pathway in absence of ligand / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ...histone H2AXY142 phosphatase activity / mesodermal cell fate specification / striated muscle tissue development / mitochondrial outer membrane permeabilization / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of DNA repair / extrinsic apoptotic signaling pathway in absence of ligand / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / cell differentiation / DNA repair / magnesium ion binding / mitochondrion / nucleoplasm / nucleus / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Anantharajan, J. / Baburajendran, N. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase. Authors: Anantharajan, J. / Baburajendran, N. / Lin, G. / Loh, Y.Y. / Xu, W. / Ahmad, N.H.B. / Liu, S. / Jansson, A.E. / Kuan, J.W.L. / Ng, E.Y. / Yeo, Y.K. / Hung, A.W. / Joy, J. / Hill, J. / Ford, ...Authors: Anantharajan, J. / Baburajendran, N. / Lin, G. / Loh, Y.Y. / Xu, W. / Ahmad, N.H.B. / Liu, S. / Jansson, A.E. / Kuan, J.W.L. / Ng, E.Y. / Yeo, Y.K. / Hung, A.W. / Joy, J. / Hill, J. / Ford, H.L. / Zhao, R. / Keller, T.H. / Kang, C. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 165.6 KB | Display | ![]() |
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PDB format | ![]() | 126.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1.1 MB | Display | ![]() |
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Full document | ![]() | 1.1 MB | Display | |
Data in XML | ![]() | 28 KB | Display | |
Data in CIF | ![]() | 36.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7f8gC ![]() 5zmaS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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