登録情報 データベース : PDB / ID : 7.0E+72 構造の表示 ダウンロードとリンクタイトル Crystal structure of Tie2-agonistic antibody in complex with human Tie2 Fn2-3 要素Angiopoietin-1 receptor the chimeric Fab fragment of 3H7 (heavy chain) the chimeric Fab fragment of 3H7 (light chain) 詳細キーワード MEMBRANE PROTEIN / antigen-antibody complex / agonistic antibody / angiogenesis / vascular stabilization / receptor tyrosine kinase / Tie2機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Tie signaling pathway / glomerulus vasculature development / regulation of establishment or maintenance of cell polarity / regulation of endothelial cell apoptotic process / regulation of vascular permeability / endochondral ossification / heart trabecula formation / definitive hemopoiesis / sprouting angiogenesis / endothelial cell proliferation ... Tie signaling pathway / glomerulus vasculature development / regulation of establishment or maintenance of cell polarity / regulation of endothelial cell apoptotic process / regulation of vascular permeability / endochondral ossification / heart trabecula formation / definitive hemopoiesis / sprouting angiogenesis / endothelial cell proliferation / positive regulation of intracellular signal transduction / positive regulation of Rho protein signal transduction / positive regulation of Rac protein signal transduction / growth factor binding / positive regulation of focal adhesion assembly / microvillus / centriolar satellite / negative regulation of endothelial cell apoptotic process / Tie2 Signaling / response to cAMP / cell surface receptor protein tyrosine kinase signaling pathway / positive regulation of endothelial cell proliferation / positive regulation of endothelial cell migration / transmembrane receptor protein tyrosine kinase activity / negative regulation of angiogenesis / substrate adhesion-dependent cell spreading / basal plasma membrane / receptor protein-tyrosine kinase / response to peptide hormone / negative regulation of inflammatory response / response to estrogen / positive regulation of angiogenesis / cell-cell junction / cell-cell signaling / signaling receptor activity / heart development / RAF/MAP kinase cascade / basolateral plasma membrane / angiogenesis / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / response to hypoxia / receptor complex / protein kinase activity / positive regulation of protein phosphorylation / membrane raft / apical plasma membrane / focal adhesion / negative regulation of apoptotic process / cell surface / extracellular region / ATP binding / identical protein binding / plasma membrane / cytoplasm 類似検索 - 分子機能 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal / Tie-2 Ig-like domain 1 / Laminin-type EGF domain / : / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / Fibronectin type III domain / EGF-like domain ... Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal / Tie-2 Ig-like domain 1 / Laminin-type EGF domain / : / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain signature 1. / Fibronectin type III domain / EGF-like domain / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.094 Å 詳細データ登録者 Kim, H.M. / Jo, G.H. / Hong, H.J. / Han, A. 資金援助 韓国, 2件 詳細 詳細を隠す組織 認可番号 国 Other government Institute for Basic Science, IBS-R030-C1 韓国 Other government Institute for Basic Science, IBS-R025-D1 韓国
引用ジャーナル : Nat Commun / 年 : 2021タイトル : Structural insights into the clustering and activation of Tie2 receptor mediated by Tie2 agonistic antibody.著者 : Jo, G. / Bae, J. / Hong, H.J. / Han, A.R. / Kim, D.K. / Hong, S.P. / Kim, J.A. / Lee, S. / Koh, G.Y. / Kim, H.M. 履歴 登録 2021年2月25日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年11月10日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月29日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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