登録情報 データベース : PDB / ID : 7dhs 構造の表示 ダウンロードとリンクタイトル Crystal Structure Analysis of the BRD4 要素Bromodomain-containing protein 4 詳細 キーワード STRUCTURAL PROTEIN / BRD4 / Bromodomain機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.76 Å 詳細データ登録者 Wu, T. / Xiang, Q. / Wang, C. / Wu, C. / Zhang, C. / Zhang, M. / Liu, Z. / Zhang, Y. / Xiao, L. / Xu, Y. 引用ジャーナル : Acta Pharmacol.Sin. / 年 : 2021タイトル : Y06014 is a selective BET inhibitor for the treatment of prostate cancer.著者 : Wu, T.B. / Xiang, Q.P. / Wang, C. / Wu, C. / Zhang, C. / Zhang, M.F. / Liu, Z.X. / Zhang, Y. / Xiao, L.J. / Xu, Y. 履歴 登録 2020年11月17日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年9月15日 Provider : repository / タイプ : Initial release改定 1.1 2022年2月16日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.2 2023年11月29日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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