登録情報 データベース : PDB / ID : 7df6 構造の表示 ダウンロードとリンクタイトル Mouse Galectin-3 CRD in complex with novel tetrahydropyran-based thiodisaccharide mimic inhibitor 要素Galectin-3 詳細 キーワード CARBOHYDRATE / Galectin-3 Carbohydrate Recognition Domain / Inhibitor / Complex / Tetrahydropyran / Thiodigalactoside機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of cell proliferation in bone marrow / advanced glycation end-product receptor activity / positive regulation of serotonin secretion / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / cornified envelope / negative regulation of endocytosis / IgE binding / Fc-gamma receptor I complex binding ... negative regulation of cell proliferation in bone marrow / advanced glycation end-product receptor activity / positive regulation of serotonin secretion / negative regulation of immunological synapse formation / disaccharide binding / negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell / cornified envelope / negative regulation of endocytosis / IgE binding / Fc-gamma receptor I complex binding / eosinophil chemotaxis / monosaccharide binding / negative regulation of T cell receptor signaling pathway / positive chemotaxis / macrophage chemotaxis / positive regulation of calcium ion import / monocyte chemotaxis / glial cell projection / immunological synapse / laminin binding / neutrophil chemotaxis / Neutrophil degranulation / extracellular matrix / RNA splicing / extracellular matrix organization / skeletal system development / negative regulation of extrinsic apoptotic signaling pathway / spliceosomal complex / mRNA processing / positive regulation of angiogenesis / collagen-containing extracellular matrix / cell differentiation / external side of plasma membrane / innate immune response / positive regulation of cell population proliferation / negative regulation of apoptotic process / cell surface / extracellular space / extracellular region / nucleus / cytoplasm 類似検索 - 分子機能 Galectin-like / Galactoside-binding lectin / Galectin / Galectin, carbohydrate recognition domain / Galactoside-binding lectin / Galactoside-binding lectin (galectin) domain profile. / Concanavalin A-like lectin/glucanase domain superfamily 類似検索 - ドメイン・相同性生物種 Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.8 Å 詳細データ登録者 Ghosh, K. / Kumar, A. 引用ジャーナル : J.Med.Chem. / 年 : 2021タイトル : Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors.著者 : Xu, L. / Hartz, R.A. / Beno, B.R. / Ghosh, K. / Shukla, J.K. / Kumar, A. / Patel, D. / Kalidindi, N. / Lemos, N. / Gautam, S.S. / Kumar, A. / Ellsworth, B.A. / Shah, D. / Sale, H. / Cheng, D. / Regueiro-Ren, A. 履歴 登録 2020年11月6日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年6月23日 Provider : repository / タイプ : Initial release改定 1.1 2023年11月29日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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