登録情報 | データベース: PDB / ID: 7d6y |
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タイトル | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain |
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要素 | - Eukaryotic translation initiation factor 4E
- VH Domain (1C5)
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キーワード | RNA BINDING PROTEIN / VH domain / Cap-Dependent Translation |
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機能・相同性 | 機能・相同性情報
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4G binding / regulation of translation at postsynapse, modulating synaptic transmission / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / RNA cap binding / chromatoid body / eukaryotic translation initiation factor 4F complex / Deadenylation of mRNA / mRNA cap binding / Transport of the SLBP independent Mature mRNA ...Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / eukaryotic initiation factor 4G binding / regulation of translation at postsynapse, modulating synaptic transmission / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / RNA cap binding / chromatoid body / eukaryotic translation initiation factor 4F complex / Deadenylation of mRNA / mRNA cap binding / Transport of the SLBP independent Mature mRNA / M-decay: degradation of maternal mRNAs by maternally stored factors / Transport of the SLBP Dependant Mature mRNA / RNA 7-methylguanosine cap binding / Transport of Mature mRNA Derived from an Intronless Transcript / RISC complex / Translation initiation complex formation / Ribosomal scanning and start codon recognition / stem cell population maintenance / mTORC1-mediated signalling / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / negative regulation of neuron differentiation / behavioral fear response / mRNA export from nucleus / translational initiation / translation initiation factor activity / positive regulation of mitotic cell cycle / cellular response to dexamethasone stimulus / P-body / neuron differentiation / ISG15 antiviral mechanism / cytoplasmic ribonucleoprotein granule / cytoplasmic stress granule / G1/S transition of mitotic cell cycle / regulation of translation / postsynapse / DNA-binding transcription factor binding / negative regulation of translation / nuclear speck / glutamatergic synapse / perinuclear region of cytoplasm / enzyme binding / RNA binding / extracellular exosome / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like類似検索 - ドメイン・相同性 Chem-MGO / Eukaryotic translation initiation factor 4E類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.668 Å |
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データ登録者 | Brown, C.J. / Frosi, Y. / Jiang, S. / Lin, Y.C. |
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引用 | ジャーナル: To Be Published タイトル: Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways 著者: Frosi, Y. / Lin, Y.C. / Jiang, S. / Ramlan, S.R. / Hew, K. / Asial, I. / Engman, A.H. / Goh, M. / Thean, D. / Nordlund, P. / Lane, D.P. / Brown, C.J. |
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履歴 | 登録 | 2020年10月2日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年10月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Derived calculations / Refinement description カテゴリ: atom_type / chem_comp_atom ...atom_type / chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model Item: _atom_type.pdbx_N_electrons / _atom_type.pdbx_scat_Z |
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