Entry Database : PDB / ID : 7cwg Structure visualization Downloads & linksTitle Crystal structure of PDE8A catalytic domain in complex with 3a ComponentsHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Details Keywords HYDROLASE / cAMP-specific / Selective PDE8A inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cellular response to epidermal growth factor stimulus / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade ... 3',5'-cyclic-AMP phosphodiesterase / protein kinase activator activity / cAMP catabolic process / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cellular response to epidermal growth factor stimulus / cAMP-mediated signaling / kinase binding / G alpha (s) signalling events / positive regulation of ERK1 and ERK2 cascade / regulation of DNA-templated transcription / perinuclear region of cytoplasm / extracellular exosome / nucleus / metal ion binding / cytosol Similarity search - Function 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold ... 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / PAS fold / PAS fold / PAS repeat profile. / PAS domain / PAS domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Huang, Y. / Wu, X.-N. / Zhou, Q. / Wu, Y. / Luo, H.-B. Funding support China, 2items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) 21877134 China National Natural Science Foundation of China (NSFC) 81522041 China
CitationJournal : J.Med.Chem. / Year : 2020Title : Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors.Authors : Huang, Y. / Wu, X.N. / Zhou, Q. / Wu, Y. / Zheng, D. / Li, Z. / Guo, L. / Luo, H.B. History Deposition Aug 28, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Sep 1, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Mar 16, 2022 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 29, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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