Entry Database : PDB / ID : 7cqf Structure visualization Downloads & linksTitle Crystal structure of PSD-95 PDZ3 fused with ADAM22 C-terminal peptide ComponentsDisks large homolog 4,Disintegrin and metalloproteinase domain-containing protein 22 Details Keywords SIGNALING PROTEIN / Scaffold protein / Membrane receptorFunction / homology Function and homology informationFunction Domain/homology Component
RHO GTPases activate CIT / LGI-ADAM interactions / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins / beta-1 adrenergic receptor binding / neuroligin family protein binding / structural constituent of postsynaptic density / proximal dendrite ... RHO GTPases activate CIT / LGI-ADAM interactions / positive regulation of AMPA glutamate receptor clustering / neuronal ion channel clustering / P2Y1 nucleotide receptor binding / Neurexins and neuroligins / beta-1 adrenergic receptor binding / neuroligin family protein binding / structural constituent of postsynaptic density / proximal dendrite / positive regulation of neuron projection arborization / regulation of grooming behavior / synaptic vesicle maturation / embryo development / receptor localization to synapse / cerebellar mossy fiber / cellular response to potassium ion / protein localization to synapse / vocalization behavior / LGI-ADAM interactions / Trafficking of AMPA receptors / dendritic branch / neuron spine / Activation of Ca-permeable Kainate Receptor / AMPA glutamate receptor clustering / juxtaparanode region of axon / negative regulation of cell adhesion / dendritic spine morphogenesis / frizzled binding / negative regulation of receptor internalization / dendritic spine organization / neuron projection terminus / acetylcholine receptor binding / postsynaptic neurotransmitter receptor diffusion trapping / establishment or maintenance of epithelial cell apical/basal polarity / positive regulation of synapse assembly / Synaptic adhesion-like molecules / regulation of NMDA receptor activity / RAF/MAP kinase cascade / neurotransmitter receptor localization to postsynaptic specialization membrane / positive regulation of dendrite morphogenesis / cortical cytoskeleton / locomotory exploration behavior / regulation of neuronal synaptic plasticity / kinesin binding / positive regulation of excitatory postsynaptic potential / social behavior / AMPA glutamate receptor complex / neuromuscular process controlling balance / excitatory synapse / positive regulation of protein tyrosine kinase activity / D1 dopamine receptor binding / Unblocking of NMDA receptors, glutamate binding and activation / glutamate receptor binding / positive regulation of synaptic transmission / beta-2 adrenergic receptor binding / extrinsic component of cytoplasmic side of plasma membrane / dendrite cytoplasm / synaptic membrane / central nervous system development / cell periphery / PDZ domain binding / postsynaptic density membrane / regulation of long-term neuronal synaptic plasticity / ionotropic glutamate receptor binding / establishment of protein localization / neuromuscular junction / cerebral cortex development / metalloendopeptidase activity / kinase binding / cell-cell adhesion / cell-cell junction / integrin binding / synaptic vesicle / cell junction / positive regulation of cytosolic calcium ion concentration / scaffold protein binding / postsynapse / protein-containing complex assembly / chemical synaptic transmission / basolateral plasma membrane / postsynaptic membrane / protein phosphatase binding / dendritic spine / postsynaptic density / cell adhesion / neuron projection / axon / signaling receptor binding / glutamatergic synapse / synapse / dendrite / protein-containing complex binding / protein kinase binding / endoplasmic reticulum / proteolysis / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. / Peptidase M12B, propeptide / Reprolysin family propeptide / Reprolysin domain, adamalysin-type / Reprolysin (M12B) family zinc metalloprotease / Disintegrin ... ADAM cysteine-rich / ADAM, cysteine-rich domain / ADAM Cysteine-Rich Domain / Disintegrin, conserved site / Disintegrins signature. / Peptidase M12B, propeptide / Reprolysin family propeptide / Reprolysin domain, adamalysin-type / Reprolysin (M12B) family zinc metalloprotease / Disintegrin / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disintegrin domain profile. / Homologues of snake disintegrins / Disintegrin domain / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disintegrin domain superfamily / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Peptidase M12B, ADAM/reprolysin / ADAM type metalloprotease domain profile. / Guanylate kinase, conserved site / Guanylate kinase-like signature. / EGF-like domain, extracellular / EGF-like domain / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / Metallopeptidase, catalytic domain superfamily / PDZ domain / EGF-like domain signature 1. / EGF-like domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.8 Å DetailsAuthors Yamagata, A. / Fukai, S. Funding support Japan, 1items Details Hide detailsOrganization Grant number Country Japan Society for the Promotion of Science (JSPS) 18H03983 Japan
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2021Title : LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.Authors : Fukata, Y. / Chen, X. / Chiken, S. / Hirano, Y. / Yamagata, A. / Inahashi, H. / Sanbo, M. / Sano, H. / Goto, T. / Hirabayashi, M. / Kornau, H.C. / Pruss, H. / Nambu, A. / Fukai, S. / Nicoll, R.A. / Fukata, M. History Deposition Aug 10, 2020 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 6, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Jan 20, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 29, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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