登録情報 | データベース: PDB / ID: 7ax1 |
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タイトル | Crystal structure of the human CCR4-CAF1 complex |
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要素 | - CCR4-NOT transcription complex subunit 6
- CCR4-NOT transcription complex subunit 7
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キーワード | RNA BINDING PROTEIN / Deadenylation / mRNA decay / CCR4-NOT complex / EEP hydrolase / DEDDh hydrolase |
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機能・相同性 | 機能・相同性情報
: / regulation of tyrosine phosphorylation of STAT protein / positive regulation of cytoplasmic mRNA processing body assembly / poly(A)-specific ribonuclease / piRNA binding / nuclear-transcribed mRNA catabolic process, no-go decay / piRNA-mediated gene silencing by mRNA destabilization / poly(A)-specific ribonuclease activity / RNA exonuclease activity / CCR4-NOT core complex ...: / regulation of tyrosine phosphorylation of STAT protein / positive regulation of cytoplasmic mRNA processing body assembly / poly(A)-specific ribonuclease / piRNA binding / nuclear-transcribed mRNA catabolic process, no-go decay / piRNA-mediated gene silencing by mRNA destabilization / poly(A)-specific ribonuclease activity / RNA exonuclease activity / CCR4-NOT core complex / CCR4-NOT complex / miRNA-mediated gene silencing by mRNA destabilization / positive regulation of mRNA catabolic process / nuclear-transcribed mRNA poly(A) tail shortening / deadenylation-dependent decapping of nuclear-transcribed mRNA / Deadenylation of mRNA / M-decay: degradation of maternal mRNAs by maternally stored factors / regulatory ncRNA-mediated gene silencing / nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / P-body assembly / negative regulation of type I interferon-mediated signaling pathway / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / intracellular membraneless organelle / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / positive regulation of viral genome replication / P-body / Activation of anterior HOX genes in hindbrain development during early embryogenesis / transcription corepressor activity / regulation of translation / 3'-5'-RNA exonuclease activity / defense response to virus / DNA-binding transcription factor binding / nuclear speck / nuclear body / negative regulation of cell population proliferation / negative regulation of gene expression / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of transcription by RNA polymerase II / RNA binding / metal ion binding / nucleus / membrane / cytosol / cytoplasm類似検索 - 分子機能 CCR4-NOT transcription complex subunit 6 / CCR4-NOT transcription complex subunit 7/8/Pop2 / : / Ribonuclease CAF1 / CAF1 family ribonuclease / Deoxyribonuclease I; Chain A / Endonuclease/exonuclease/phosphatase / Endonuclease/exonuclease/phosphatase / Endonuclease/Exonuclease/phosphatase family / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) ...CCR4-NOT transcription complex subunit 6 / CCR4-NOT transcription complex subunit 7/8/Pop2 / : / Ribonuclease CAF1 / CAF1 family ribonuclease / Deoxyribonuclease I; Chain A / Endonuclease/exonuclease/phosphatase / Endonuclease/exonuclease/phosphatase / Endonuclease/Exonuclease/phosphatase family / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / Ribonuclease Inhibitor / Endonuclease/exonuclease/phosphatase superfamily / Alpha-Beta Horseshoe / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily / 4-Layer Sandwich / Ribonuclease H superfamily / Ribonuclease H-like superfamily / Alpha Beta類似検索 - ドメイン・相同性 CCR4-NOT transcription complex subunit 7 / CCR4-NOT transcription complex subunit 6類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.3 Å |
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データ登録者 | Chen, Y. / Khazina, E. / Weichenrieder, O. |
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引用 | ジャーナル: Nucleic Acids Res. / 年: 2021 タイトル: Crystal structure and functional properties of the human CCR4-CAF1 deadenylase complex. 著者: Chen, Y. / Khazina, E. / Izaurralde, E. / Weichenrieder, O. |
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履歴 | 登録 | 2020年11月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年5月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年6月9日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2021年6月30日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月31日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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