Entry Database : PDB / ID : 7ag0 Structure visualization Downloads & linksTitle Complex between the bone morphogenetic protein 2 and its antagonist Noggin ComponentsBone morphogenetic protein 2 Noggin DetailsKeywords CYTOKINE / Bmp-2 / TGF-beta superfamily / cysteine-knotFunction / homology Function and homology informationFunction Domain/homology Component
neural plate anterior/posterior regionalization / negative regulation of cardiac epithelial to mesenchymal transition / notochord morphogenesis / neural plate morphogenesis / cell differentiation in hindbrain / negative regulation of cytokine activity / regulation of fibroblast growth factor receptor signaling pathway / ureteric bud formation / cardiac atrium formation / cardiocyte differentiation ... neural plate anterior/posterior regionalization / negative regulation of cardiac epithelial to mesenchymal transition / notochord morphogenesis / neural plate morphogenesis / cell differentiation in hindbrain / negative regulation of cytokine activity / regulation of fibroblast growth factor receptor signaling pathway / ureteric bud formation / cardiac atrium formation / cardiocyte differentiation / negative regulation of calcium-independent cell-cell adhesion / cardiac jelly development / negative regulation of aldosterone biosynthetic process / embryonic skeletal joint morphogenesis / negative regulation of cortisol biosynthetic process / atrioventricular canal morphogenesis / mesenchymal cell proliferation involved in ureteric bud development / negative regulation of steroid biosynthetic process / embryonic heart tube anterior/posterior pattern specification / prostatic bud formation / nodal signaling pathway / positive regulation of glomerulus development / positive regulation of extracellular matrix constituent secretion / enzyme activator complex / regulation of odontogenesis of dentin-containing tooth / endodermal-mesodermal cell signaling / negative regulation of cardiac muscle cell differentiation / corticotropin hormone secreting cell differentiation / atrial cardiac muscle tissue morphogenesis / negative regulation of insulin-like growth factor receptor signaling pathway / thyroid-stimulating hormone-secreting cell differentiation / endoderm formation / positive regulation of phosphatase activity / mesenchyme development / ameloblast differentiation / aortic valve development / telencephalon regionalization / pharyngeal arch artery morphogenesis / short-term synaptic potentiation / heart induction / positive regulation of cartilage development / positive regulation of odontogenesis / positive regulation of peroxisome proliferator activated receptor signaling pathway / ventricular compact myocardium morphogenesis / pituitary gland development / lung vasculature development / pericardium development / BMP receptor complex / membranous septum morphogenesis / proteoglycan metabolic process / embryonic skeletal system development / co-receptor binding / negative regulation of cartilage development / negative regulation of cardiac muscle cell proliferation / cardiac epithelial to mesenchymal transition / mesenchymal cell differentiation / somite development / BMP receptor binding / telencephalon development / positive regulation of odontoblast differentiation / positive regulation of bone mineralization involved in bone maturation / cranial skeletal system development / endocardial cushion formation / Transcriptional regulation by RUNX2 / phosphatase activator activity / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of astrocyte differentiation / heart trabecula morphogenesis / cellular response to BMP stimulus / cardiac muscle cell differentiation / Signaling by BMP / astrocyte differentiation / axial mesoderm development / positive regulation of ossification / cardiac muscle tissue morphogenesis / motor neuron axon guidance / dorsal/ventral pattern formation / positive regulation of p38MAPK cascade / limb development / face morphogenesis / atrioventricular valve morphogenesis / cartilage development / exploration behavior / middle ear morphogenesis / endocardial cushion morphogenesis / Molecules associated with elastic fibres / branching involved in ureteric bud morphogenesis / embryonic digit morphogenesis / smoothened signaling pathway / ventricular septum morphogenesis / negative regulation of SMAD protein signal transduction / spinal cord development / negative regulation of fat cell differentiation / Formation of paraxial mesoderm / bone mineralization / cytokine binding / positive regulation of osteoblast proliferation / lung morphogenesis / : / odontogenesis of dentin-containing tooth Similarity search - Function Noggin / Noggin / : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal ... Noggin / Noggin / : / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.104 Å DetailsAuthors Robert, C. / Bruck, F. / Herman, R. / Vandevenne, M. / Filee, P. / Kerff, F. / Matagne, A. Funding support Belgium, 1items Details Hide detailsOrganization Grant number Country Walloon Region #16100518 AUTOBMP-2 Belgium
CitationJournal : J.Biol.Chem. / Year : 2023Title : Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition.Authors : Robert, C. / Kerff, F. / Bouillenne, F. / Gavage, M. / Vandevenne, M. / Filee, P. / Matagne, A. History Deposition Sep 21, 2020 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 13, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Apr 26, 2023 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name Revision 1.2 Feb 7, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_modelRevision 1.3 Nov 6, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature / Item : _pdbx_entry_details.has_protein_modification
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