Entry Database : PDB / ID : 6zz4 Structure visualization Downloads & linksTitle Crystal structure of the PTPN2 C216G mutant ComponentsTyrosine-protein phosphatase non-receptor type 2 Details Keywords SIGNALING PROTEIN / PhosphataseFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of interleukin-2-mediated signaling pathway / negative regulation of interleukin-4-mediated signaling pathway / negative regulation of positive thymic T cell selection / positive regulation of PERK-mediated unfolded protein response / negative regulation of platelet-derived growth factor receptor-beta signaling pathway / negative regulation of macrophage colony-stimulating factor signaling pathway / negative regulation of interleukin-6-mediated signaling pathway / negative regulation of macrophage differentiation / regulation of type II interferon-mediated signaling pathway / negative regulation of chemotaxis ... negative regulation of interleukin-2-mediated signaling pathway / negative regulation of interleukin-4-mediated signaling pathway / negative regulation of positive thymic T cell selection / positive regulation of PERK-mediated unfolded protein response / negative regulation of platelet-derived growth factor receptor-beta signaling pathway / negative regulation of macrophage colony-stimulating factor signaling pathway / negative regulation of interleukin-6-mediated signaling pathway / negative regulation of macrophage differentiation / regulation of type II interferon-mediated signaling pathway / negative regulation of chemotaxis / negative regulation of tyrosine phosphorylation of STAT protein / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / STAT family protein binding / negative regulation of epidermal growth factor receptor signaling pathway / negative regulation of receptor signaling pathway via JAK-STAT / negative regulation of type II interferon-mediated signaling pathway / Interleukin-37 signaling / negative regulation of lipid storage / syntaxin binding / negative regulation of type I interferon-mediated signaling pathway / negative regulation of T cell receptor signaling pathway / regulation of hepatocyte growth factor receptor signaling pathway / insulin receptor recycling / endoplasmic reticulum-Golgi intermediate compartment / non-membrane spanning protein tyrosine phosphatase activity / peptidyl-tyrosine dephosphorylation / T cell differentiation / negative regulation of tumor necrosis factor-mediated signaling pathway / Regulation of IFNG signaling / positive regulation of gluconeogenesis / negative regulation of insulin receptor signaling pathway / protein-tyrosine-phosphatase / B cell differentiation / erythrocyte differentiation / protein tyrosine phosphatase activity / endosome lumen / negative regulation of inflammatory response / PKR-mediated signaling / Negative regulation of MET activity / negative regulation of ERK1 and ERK2 cascade / receptor tyrosine kinase binding / integrin binding / glucose homeostasis / insulin receptor signaling pathway / negative regulation of cell population proliferation / protein kinase binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function Protein-tyrosine phosphatase, non-receptor type-1/2 / : / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site ... Protein-tyrosine phosphatase, non-receptor type-1/2 / : / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.43 Å DetailsAuthors Mechaly, A.E. / Berthelet, J. / Nian, Q. / Parlato, M. / Cerf-Bensussan, N. / Haouz, A. / Rodrigues-Lima, F. CitationJournal : Protein Sci. / Year : 2022Title : Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.Authors : Nian, Q. / Berthelet, J. / Parlato, M. / Mechaly, A.E. / Liu, R. / Dupret, J.M. / Cerf-Bensussan, N. / Haouz, A. / Rodrigues Lima, F. History Deposition Aug 3, 2020 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 18, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Mar 9, 2022 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 31, 2024 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ... _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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