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Yorodumi- PDB-6ylt: Translation initiation factor 4E in complex with 3-MeBn7GpppG mRN... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6ylt | |||||||||
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Title | Translation initiation factor 4E in complex with 3-MeBn7GpppG mRNA 5' cap analog | |||||||||
Components | Eukaryotic translation initiation factor 4E | |||||||||
Keywords | TRANSLATION / cap analog / translation initiation factor / 3-MeBn7GpppG / protein-ligand complex / eIF4E | |||||||||
Function / homology | Function and homology information Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / Deadenylation of mRNA / Translation initiation complex formation / Ribosomal scanning and start codon recognition / ISG15 antiviral mechanism / mTORC1-mediated signalling / L13a-mediated translational silencing of Ceruloplasmin expression ...Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / Deadenylation of mRNA / Translation initiation complex formation / Ribosomal scanning and start codon recognition / ISG15 antiviral mechanism / mTORC1-mediated signalling / L13a-mediated translational silencing of Ceruloplasmin expression / GTP hydrolysis and joining of the 60S ribosomal subunit / eukaryotic initiation factor 4G binding / regulation of translation at postsynapse, modulating synaptic transmission / chromatoid body / eukaryotic translation initiation factor 4F complex / mRNA cap binding / RNA 7-methylguanosine cap binding / RISC complex / nuclear export / postsynaptic cytosol / stem cell population maintenance / negative regulation of neuron differentiation / behavioral fear response / cellular response to dexamethasone stimulus / mRNA export from nucleus / translation initiation factor activity / positive regulation of mitotic cell cycle / translational initiation / P-body / G1/S transition of mitotic cell cycle / neuron differentiation / cytoplasmic stress granule / regulation of translation / DNA-binding transcription factor binding / postsynapse / nuclear body / negative regulation of translation / nuclear speck / translation / glutamatergic synapse / perinuclear region of cytoplasm / enzyme binding / protein-containing complex / nucleus / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | Mus musculus (house mouse) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.67 Å | |||||||||
Authors | Kubacka, D. / Wojcik, R. / Baranowski, M.R. / Kowalska, J. / Jemielity, J. | |||||||||
Funding support | Poland, 2items
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Citation | Journal: Pharmaceutics / Year: 2021 Title: Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5' cap Analogs: Synthesis and Evaluation as Modulators of Translation. Authors: Wojcik, R. / Baranowski, M.R. / Markiewicz, L. / Kubacka, D. / Bednarczyk, M. / Baran, N. / Wojtczak, A. / Sikorski, P.J. / Zuberek, J. / Kowalska, J. / Jemielity, J. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6ylt.cif.gz | 204.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6ylt.ent.gz | 133.2 KB | Display | PDB format |
PDBx/mmJSON format | 6ylt.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/yl/6ylt ftp://data.pdbj.org/pub/pdb/validation_reports/yl/6ylt | HTTPS FTP |
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-Related structure data
Related structure data | 6ylrC 6ylvC 1l8bS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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