登録情報 データベース : PDB / ID : 6ykd 構造の表示 ダウンロードとリンクタイトル Human Pim-1 kinase in complex with an inhibitor identified by virtual screening 要素Serine/threonine-protein kinase pim-1 詳細 キーワード APOPTOSIS / KINASE / CANCER / TRANSFERASE / ATP-BINDING / virtual screening機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / cellular detoxification / vitamin D receptor signaling pathway / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling ... positive regulation of cardioblast proliferation / regulation of hematopoietic stem cell proliferation / cellular detoxification / vitamin D receptor signaling pathway / STAT5 activation downstream of FLT3 ITD mutants / transcription factor binding / positive regulation of cyclin-dependent protein serine/threonine kinase activity / ribosomal small subunit binding / positive regulation of cardiac muscle cell proliferation / positive regulation of TORC1 signaling / Signaling by FLT3 fusion proteins / negative regulation of innate immune response / positive regulation of brown fat cell differentiation / protein serine/threonine kinase activator activity / regulation of transmembrane transporter activity / positive regulation of protein serine/threonine kinase activity / negative regulation of DNA-binding transcription factor activity / cellular response to type II interferon / manganese ion binding / Interleukin-4 and Interleukin-13 signaling / protein autophosphorylation / protein stabilization / non-specific serine/threonine protein kinase / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / apoptotic process / nucleolus / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Serine/threonine-protein kinase pim-1/2/3 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site ... Serine/threonine-protein kinase pim-1/2/3 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 ACETATE ION / Chem-OWB / Serine/threonine-protein kinase pim-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.86 Å 詳細データ登録者 Schneider, P. / Welin, M. / Svensson, B. / Walse, B. / Schneider, G. 引用ジャーナル : Mol Inform / 年 : 2020タイトル : Virtual Screening and Design with Machine Intelligence Applied to Pim-1 Kinase Inhibitors.著者 : Schneider, P. / Welin, M. / Svensson, B. / Walse, B. / Schneider, G. 履歴 登録 2020年4月6日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年7月1日 Provider : repository / タイプ : Initial release改定 1.1 2021年1月20日 Group : Database references / Refinement description / カテゴリ : citation / citation_author / softwareItem : _citation.journal_abbrev / _citation.journal_id_CSD ... _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.title / _citation.year / _citation_author.identifier_ORCID / _software.name 改定 1.2 2021年1月27日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_id_ISSN / _citation.page_first ... _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID 改定 1.3 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model Item : _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
すべて表示 表示を減らす