登録情報 データベース : PDB / ID : 6ygj 構造の表示 ダウンロードとリンクタイトル small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction 要素(14-3-3 protein beta/alpha) x 2 Carbohydrate-responsive element-binding protein 詳細キーワード STRUCTURAL PROTEIN / 14-3-3 / Stabilizer / protein-protein interaction / ChREBP / small molecule機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
carbohydrate response element binding / glucose mediated signaling pathway / PKA-mediated phosphorylation of key metabolic factors / AMPK inhibits chREBP transcriptional activation activity / PP2A-mediated dephosphorylation of key metabolic factors / positive regulation of transcription from RNA polymerase II promoter by glucose / negative regulation of protein dephosphorylation / cytoplasmic sequestering of protein / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / negative regulation of G protein-coupled receptor signaling pathway ... carbohydrate response element binding / glucose mediated signaling pathway / PKA-mediated phosphorylation of key metabolic factors / AMPK inhibits chREBP transcriptional activation activity / PP2A-mediated dephosphorylation of key metabolic factors / positive regulation of transcription from RNA polymerase II promoter by glucose / negative regulation of protein dephosphorylation / cytoplasmic sequestering of protein / Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA / negative regulation of G protein-coupled receptor signaling pathway / Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA / ChREBP activates metabolic gene expression / MTOR signalling / positive regulation of fatty acid biosynthetic process / ARMS-mediated activation / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / Rap1 signalling / negative regulation of oxidative phosphorylation / Signaling by Hippo / triglyceride homeostasis / vacuolar membrane / lipid biosynthetic process / DNA-binding transcription activator activity / Frs2-mediated activation / positive regulation of catalytic activity / protein kinase inhibitor activity / negative regulation of peptidyl-serine phosphorylation / mTORC1-mediated signalling / Regulation of localization of FOXO transcription factors / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / anatomical structure morphogenesis / fatty acid homeostasis / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / energy homeostasis / positive regulation of lipid biosynthetic process / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / positive regulation of glycolytic process / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / phosphoprotein binding / RAF activation / Signaling by high-kinase activity BRAF mutants / MAP2K and MAPK activation / DNA-binding transcription repressor activity, RNA polymerase II-specific / histone deacetylase binding / RNA polymerase II transcription regulator complex / Negative regulation of MAPK pathway / Signaling by RAF1 mutants / Signaling by moderate kinase activity BRAF mutants / Paradoxical activation of RAF signaling by kinase inactive BRAF / Signaling downstream of RAS mutants / Signaling by BRAF and RAF1 fusions / melanosome / glucose homeostasis / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription regulator complex / DNA-binding transcription factor activity, RNA polymerase II-specific / cadherin binding / protein heterodimerization activity / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / protein domain specific binding / focal adhesion / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / enzyme binding / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Helix-loop-helix DNA-binding domain / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Helix-loop-helix DNA-binding domain superfamily ... Helix-loop-helix DNA-binding domain / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. 類似検索 - ドメイン・相同性 Chem-OQE / 14-3-3 protein beta/alpha / Carbohydrate-responsive element-binding protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.07 Å 詳細データ登録者 Ottmann, C. / Visser, E.J. 資金援助 オランダ, ドイツ, 4件 詳細 詳細を隠す組織 認可番号 国 Netherlands Organisation for Scientific Research (NWO) 024.001.035 オランダ Netherlands Organisation for Scientific Research (NWO) 016.150.366 オランダ Netherlands Organisation for Scientific Research (NWO) 711.018.003 オランダ German Research Foundation (DFG) CRC1093 ドイツ
引用ジャーナル : Nat Commun / 年 : 2020タイトル : Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.著者 : Sijbesma, E. / Visser, E. / Plitzko, K. / Thiel, P. / Milroy, L.G. / Kaiser, M. / Brunsveld, L. / Ottmann, C. 履歴 登録 2020年3月27日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年9月16日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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