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TitleStructure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions.
Journal, issue, pagesNat Commun, Vol. 11, Page 3954-3954, Year 2020
Publish dateMar 27, 2020 (structure data deposition date)
AuthorsSijbesma, E. / Visser, E. / Plitzko, K. / Thiel, P. / Milroy, L.G. / Kaiser, M. / Brunsveld, L. / Ottmann, C.
External linksNat Commun / PubMed:32770072
MethodsX-ray diffraction
Resolution2.07 Å
Structure data

PDB-6ygj:
small-molecule stabilizer of 14-3-3 and the Carbohydrate Response Element Binding Protein (ChREBP) protein-protein interaction
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-OQE:
[2-[2-oxidanylidene-2-(2-phenylethylamino)ethoxy]phenyl]phosphonic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / 14-3-3 / Stabilizer / protein-protein interaction / ChREBP / small molecule

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