登録情報 | データベース: PDB / ID: 6yek |
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タイトル | Crystal structure of human NEMO apo form |
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要素 | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b |
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キーワード | PROTEIN BINDING / Cell signaling / NF-kB pathway |
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機能・相同性 | 機能・相同性情報
IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / SLC15A4:TASL-dependent IRF5 activation / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / RIP-mediated NFkB activation via ZBP1 ...IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / SLC15A4:TASL-dependent IRF5 activation / IkappaB kinase complex / establishment of vesicle localization / linear polyubiquitin binding / transferrin receptor binding / IkBA variant leads to EDA-ID / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / RIP-mediated NFkB activation via ZBP1 / SUMOylation of immune response proteins / positive regulation of ubiquitin-dependent protein catabolic process / anoikis / K63-linked polyubiquitin modification-dependent protein binding / positive regulation of T cell receptor signaling pathway / TRAF6 mediated NF-kB activation / positive regulation of macroautophagy / polyubiquitin modification-dependent protein binding / canonical NF-kappaB signal transduction / signaling adaptor activity / ubiquitin ligase complex / phosphorylation / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / TICAM1, RIP1-mediated IKK complex recruitment / MAP3K8 (TPL2)-dependent MAPK1/3 activation / IKK complex recruitment mediated by RIP1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / TNFR1-induced NF-kappa-B signaling pathway / Regulation of NF-kappa B signaling / activated TAK1 mediates p38 MAPK activation / Activation of NF-kappaB in B cells / Regulation of TNFR1 signaling / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / response to virus / PKR-mediated signaling / mitotic spindle / CLEC7A (Dectin-1) signaling / spindle pole / FCERI mediated NF-kB activation / Interleukin-1 signaling / Ovarian tumor domain proteases / Downstream TCR signaling / positive regulation of NF-kappaB transcription factor activity / kinase activity / T cell receptor signaling pathway / ER-Phagosome pathway / protein-containing complex assembly / positive regulation of canonical NF-kappaB signal transduction / Ub-specific processing proteases / defense response to bacterium / inflammatory response / immune response / protein heterodimerization activity / protein domain specific binding / innate immune response / ubiquitin protein ligase binding / DNA damage response / apoptotic process / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / protein-containing complex / nucleoplasm / identical protein binding / nucleus / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 : / C2H2 type zinc-finger / NF-kappa-B essential modulator NEMO, N-terminal / NF-kappa-B essential modulator NEMO / NEMO, Zinc finger / Zinc finger CCHC NOA-type profile. / NF-kappa-B essential modulator NEMO, CC2-LZ domain / Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator類似検索 - ドメイン・相同性 Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform CRA_b / NF-kappa-B essential modulator類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Garcia-Pardo, J. / Akutsu, M. / Busse, P. / Skenderovic, A. / Maculins, T. / Dikic, I. |
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引用 | ジャーナル: Cell Chem Biol / 年: 2020 タイトル: Discovery of Protein-Protein Interaction Inhibitors by Integrating Protein Engineering and Chemical Screening Platforms. 著者: Maculins, T. / Garcia-Pardo, J. / Skenderovic, A. / Gebel, J. / Putyrski, M. / Vorobyov, A. / Busse, P. / Varga, G. / Kuzikov, M. / Zaliani, A. / Rahighi, S. / Schaeffer, V. / Parnham, M.J. / ...著者: Maculins, T. / Garcia-Pardo, J. / Skenderovic, A. / Gebel, J. / Putyrski, M. / Vorobyov, A. / Busse, P. / Varga, G. / Kuzikov, M. / Zaliani, A. / Rahighi, S. / Schaeffer, V. / Parnham, M.J. / Sidhu, S.S. / Ernst, A. / Dotsch, V. / Akutsu, M. / Dikic, I. |
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履歴 | 登録 | 2020年3月25日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年3月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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