登録情報 データベース : PDB / ID : 6xz8 構造の表示 ダウンロードとリンクタイトル Structure of aldosterone synthase (CYP11B2) in complex with N-[(1R)-1-[5-(6-chloro-1,1-dimethyl-3-oxo-isoindolin-2-yl)-3-pyridyl]ethyl]methanesulfonamide 要素Cytochrome P450 11B2, mitochondrial 詳細 キーワード OXIDOREDUCTASE / CYTOCHROME P450 / CYP11B2 / ALDOSTERONE SYNTHASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
corticosterone 18-monooxygenase / regulation of blood volume by renal aldosterone / Defective CYP11B2 causes CMO-1 deficiency / mineralocorticoid biosynthetic process / steroid 11beta-monooxygenase / steroid 11-beta-monooxygenase activity / corticosterone 18-monooxygenase activity / cortisol metabolic process / aldosterone biosynthetic process / cortisol biosynthetic process ... corticosterone 18-monooxygenase / regulation of blood volume by renal aldosterone / Defective CYP11B2 causes CMO-1 deficiency / mineralocorticoid biosynthetic process / steroid 11beta-monooxygenase / steroid 11-beta-monooxygenase activity / corticosterone 18-monooxygenase activity / cortisol metabolic process / aldosterone biosynthetic process / cortisol biosynthetic process / Mineralocorticoid biosynthesis / glucocorticoid biosynthetic process / Glucocorticoid biosynthesis / sodium ion homeostasis / sterol metabolic process / cellular response to potassium ion / C21-steroid hormone biosynthetic process / potassium ion homeostasis / renal water homeostasis / cellular response to peptide hormone stimulus / steroid hydroxylase activity / Endogenous sterols / cellular response to hormone stimulus / cholesterol metabolic process / mitochondrial inner membrane / iron ion binding / heme binding / mitochondrion 類似検索 - 分子機能 Cytochrome P450, mitochondrial / Cytochrome p450 / Cytochrome P450 / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 HEME C / Chem-O4T / Cytochrome P450 11B2, mitochondrial 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3 Å 詳細データ登録者 Kuglstatter, A. / Joseph, C. / Benz, J. 引用ジャーナル : J.Med.Chem. / 年 : 2020タイトル : Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.著者: Liu, Y. / Wu, J. / Zhou, M. / Chen, W. / Li, D. / Wang, Z. / Hornsperger, B. / Aebi, J.D. / Marki, H.P. / Kuhn, B. / Wang, L. / Kuglstatter, A. / Benz, J. / Muller, S. / Hochstrasser, R. / ... 著者 : Liu, Y. / Wu, J. / Zhou, M. / Chen, W. / Li, D. / Wang, Z. / Hornsperger, B. / Aebi, J.D. / Marki, H.P. / Kuhn, B. / Wang, L. / Kuglstatter, A. / Benz, J. / Muller, S. / Hochstrasser, R. / Ottaviani, G. / Xin, J. / Kirchner, S. / Mohr, S. / Verry, P. / Riboulet, W. / Shen, H.C. / Mayweg, A.V. / Amrein, K. / Tan, X. 履歴 登録 2020年2月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年6月24日 Provider : repository / タイプ : Initial release改定 1.1 2020年7月22日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.name 改定 1.2 2024年5月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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