登録情報 | データベース: PDB / ID: 6xm2 |
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タイトル | The structure of the 4A11.v7 antibody in complex with human TGFb2 |
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要素 | - 4A11.v7 heavy chain Fab (VH-CH1) IgG1 humanized
- 4A11.v7 kappa light chain Fab (VL-CL) humanized
- Transforming growth factor beta-2
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キーワード | CYTOKINE/IMMUNE SYSTEM / TGFb antibody / CYTOKINE / CYTOKINE-IMMUNE SYSTEM complex |
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機能・相同性 | 機能・相同性情報
regulation of timing of catagen / regulation of apoptotic process involved in outflow tract morphogenesis / substantia propria of cornea development / negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / ascending aorta morphogenesis / uterine wall breakdown / cardioblast differentiation / positive regulation of timing of catagen / positive regulation of cardioblast differentiation / positive regulation of heart contraction ...regulation of timing of catagen / regulation of apoptotic process involved in outflow tract morphogenesis / substantia propria of cornea development / negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / ascending aorta morphogenesis / uterine wall breakdown / cardioblast differentiation / positive regulation of timing of catagen / positive regulation of cardioblast differentiation / positive regulation of heart contraction / cardiac right ventricle morphogenesis / pharyngeal arch artery morphogenesis / type III transforming growth factor beta receptor binding / regulation of transforming growth factor beta2 production / atrial septum morphogenesis / positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation / negative regulation of macrophage cytokine production / signaling / secondary palate development / glial cell migration / somatic stem cell division / heart valve morphogenesis / endocardial cushion fusion / atrial septum primum morphogenesis / membranous septum morphogenesis / positive regulation of integrin biosynthetic process / cardiac epithelial to mesenchymal transition / eye development / cranial skeletal system development / positive regulation of stress-activated MAPK cascade / embryonic digestive tract development / neural retina development / transforming growth factor beta receptor binding / type II transforming growth factor beta receptor binding / pulmonary valve morphogenesis / outflow tract septum morphogenesis / ventricular trabecula myocardium morphogenesis / cell-cell junction organization / negative regulation of Ras protein signal transduction / collagen fibril organization / positive regulation of cell adhesion mediated by integrin / embryonic limb morphogenesis / embryo development ending in birth or egg hatching / odontogenesis / dopamine biosynthetic process / Molecules associated with elastic fibres / atrioventricular valve morphogenesis / cardiac muscle cell proliferation / endocardial cushion morphogenesis / hair follicle morphogenesis / generation of neurons / ventricular septum morphogenesis / positive regulation of Notch signaling pathway / activation of protein kinase activity / positive regulation of epithelial cell migration / TGF-beta receptor signaling activates SMADs / uterus development / positive regulation of SMAD protein signal transduction / inner ear development / hemopoiesis / positive regulation of cell division / hair follicle development / ECM proteoglycans / neuron development / epithelial to mesenchymal transition / positive regulation of cell cycle / positive regulation of epithelial to mesenchymal transition / salivary gland morphogenesis / heart morphogenesis / extrinsic apoptotic signaling pathway / epithelial cell differentiation / negative regulation of angiogenesis / neutrophil chemotaxis / transforming growth factor beta receptor signaling pathway / platelet alpha granule lumen / kidney development / skeletal system development / neural tube closure / cytokine activity / response to progesterone / positive regulation of protein secretion / growth factor activity / wound healing / cell morphogenesis / negative regulation of cell growth / positive regulation of miRNA transcription / response to wounding / negative regulation of epithelial cell proliferation / male gonad development / positive regulation of immune response / positive regulation of neuron apoptotic process / cell migration / Platelet degranulation / heart development / amyloid-beta binding / regulation of cell population proliferation / positive regulation of cell growth / collagen-containing extracellular matrix / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to hypoxia類似検索 - 分子機能 Transforming growth factor beta-2 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain ...Transforming growth factor beta-2 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine類似検索 - ドメイン・相同性 Transforming growth factor beta-2 proprotein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.91 Å |
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データ登録者 | Lupardus, P.J. / Yin, J.P. |
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引用 | ジャーナル: Sci Transl Med / 年: 2021 タイトル: TGF beta 2 and TGF beta 3 isoforms drive fibrotic disease pathogenesis. 著者: Sun, T. / Huang, Z. / Liang, W.C. / Yin, J. / Lin, W.Y. / Wu, J. / Vernes, J.M. / Lutman, J. / Caplazi, P. / Jeet, S. / Wong, T. / Wong, M. / DePianto, D.J. / Morshead, K.B. / Sun, K.H. / ...著者: Sun, T. / Huang, Z. / Liang, W.C. / Yin, J. / Lin, W.Y. / Wu, J. / Vernes, J.M. / Lutman, J. / Caplazi, P. / Jeet, S. / Wong, T. / Wong, M. / DePianto, D.J. / Morshead, K.B. / Sun, K.H. / Modrusan, Z. / Vander Heiden, J.A. / Abbas, A.R. / Zhang, H. / Xu, M. / N'Diaye, E.N. / Roose-Girma, M. / Wolters, P.J. / Yadav, R. / Sukumaran, S. / Ghilardi, N. / Corpuz, R. / Emson, C. / Meng, Y.G. / Ramalingam, T.R. / Lupardus, P. / Brightbill, H.D. / Seshasayee, D. / Wu, Y. / Arron, J.R. |
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履歴 | 登録 | 2020年6月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年7月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年8月25日 | Group: Database references / カテゴリ: citation / citation_author / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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