登録情報 | データベース: PDB / ID: 6xkq |
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タイトル | Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody CV07-250 |
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要素 | - CV07-250 Heavy Chain
- CV07-250 Light Chain
- Spike protein S1
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キーワード | VIRAL PROTEIN/IMMUNE SYSTEM / SARS-CoV-2 / Antibody / Spike / Coronavirus / COVID-19 / IMMUNE SYSTEM / VIRAL PROTEIN-IMMUNE SYSTEM complex |
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機能・相同性 | 機能・相同性情報
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like ...Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | Severe acute respiratory syndrome coronavirus 2 (ウイルス) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.55 Å |
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データ登録者 | Yuan, M. / Liu, H. / Zhu, X. / Wu, N.C. / Wilson, I.A. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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Bill & Melinda Gates Foundation | OPP1170236 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI139445 | 米国 |
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引用 | ジャーナル: Cell / 年: 2020 タイトル: A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model. 著者: Kreye, J. / Reincke, S.M. / Kornau, H.C. / Sanchez-Sendin, E. / Corman, V.M. / Liu, H. / Yuan, M. / Wu, N.C. / Zhu, X. / Lee, C.D. / Trimpert, J. / Holtje, M. / Dietert, K. / Stoffler, L. / ...著者: Kreye, J. / Reincke, S.M. / Kornau, H.C. / Sanchez-Sendin, E. / Corman, V.M. / Liu, H. / Yuan, M. / Wu, N.C. / Zhu, X. / Lee, C.D. / Trimpert, J. / Holtje, M. / Dietert, K. / Stoffler, L. / von Wardenburg, N. / van Hoof, S. / Homeyer, M.A. / Hoffmann, J. / Abdelgawad, A. / Gruber, A.D. / Bertzbach, L.D. / Vladimirova, D. / Li, L.Y. / Barthel, P.C. / Skriner, K. / Hocke, A.C. / Hippenstiel, S. / Witzenrath, M. / Suttorp, N. / Kurth, F. / Franke, C. / Endres, M. / Schmitz, D. / Jeworowski, L.M. / Richter, A. / Schmidt, M.L. / Schwarz, T. / Muller, M.A. / Drosten, C. / Wendisch, D. / Sander, L.E. / Osterrieder, N. / Wilson, I.A. / Pruss, H. |
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履歴 | 登録 | 2020年6月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年10月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年11月4日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2020年11月25日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.page_first |
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改定 1.3 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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