Entry Database : PDB / ID : 6wqu Structure visualization Downloads & linksTitle CSL (RBPJ) bound to Notch3 RAM and DNA ComponentsDNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3')DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3')Neurogenic locus notch homolog protein 3 Recombining binding protein suppressor of hairless DetailsKeywords TRANSCRIPTION/SIGNALING PROTEIN/DNA / Notch signaling / DNA binding protein / transcription factor / activation complex / TRANSCRIPTION / TRANSCRIPTION-SIGNALING PROTEIN-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
glomerular capillary formation / determination of heart left/right asymmetry / regulation of generation of precursor metabolites and energy / blood vessel endothelial cell fate specification / positive regulation of ERBB signaling pathway / club cell differentiation / arterial endothelial cell fate commitment / blood vessel lumenization / regulation of timing of cell differentiation / regulation of reproductive process ... glomerular capillary formation / determination of heart left/right asymmetry / regulation of generation of precursor metabolites and energy / blood vessel endothelial cell fate specification / positive regulation of ERBB signaling pathway / club cell differentiation / arterial endothelial cell fate commitment / blood vessel lumenization / regulation of timing of cell differentiation / regulation of reproductive process / positive regulation of ephrin receptor signaling pathway / secondary heart field specification / pulmonary valve development / positive regulation of cell proliferation involved in heart morphogenesis / Defective LFNG causes SCDO3 / dorsal aorta morphogenesis / sebaceous gland development / Pre-NOTCH Processing in the Endoplasmic Reticulum / endocardium morphogenesis / regulation of cell adhesion involved in heart morphogenesis / MAML1-RBP-Jkappa- ICN1 complex / aortic valve development / auditory receptor cell fate commitment / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / positive regulation of transcription of Notch receptor target / Notch-HLH transcription pathway / Noncanonical activation of NOTCH3 / epithelial to mesenchymal transition involved in endocardial cushion formation / heart induction / cardiac left ventricle morphogenesis / epidermal cell fate specification / pituitary gland development / neuroblast differentiation / endocardium development / atrioventricular canal development / Pre-NOTCH Processing in Golgi / neuron fate commitment / cardiac muscle cell myoblast differentiation / hair follicle maturation / myeloid dendritic cell differentiation / ventricular trabecula myocardium morphogenesis / positive regulation of BMP signaling pathway / regulation of epithelial cell proliferation / inflammatory response to antigenic stimulus / negative regulation of ossification / Notch binding / negative regulation of cold-induced thermogenesis / NOTCH3 Intracellular Domain Regulates Transcription / labyrinthine layer blood vessel development / artery morphogenesis / ventricular septum morphogenesis / Notch-HLH transcription pathway / heart looping / outflow tract morphogenesis / somatic stem cell population maintenance / negative regulation of cell differentiation / humoral immune response / hemopoiesis / negative regulation of neuron differentiation / epithelial to mesenchymal transition / blood vessel remodeling / cell fate commitment / somitogenesis / negative regulation of stem cell proliferation / keratinocyte differentiation / positive regulation of cardiac muscle cell proliferation / forebrain development / Notch signaling pathway / transcription repressor complex / B cell differentiation / epithelial cell proliferation / stem cell proliferation / positive regulation of epithelial cell proliferation / NOTCH3 Activation and Transmission of Signal to the Nucleus / protein-DNA complex / positive regulation of smooth muscle cell proliferation / axon guidance / neuron differentiation / Pre-NOTCH Transcription and Translation / positive regulation of miRNA transcription / positive regulation of canonical Wnt signaling pathway / signaling receptor activity / heart development / regulation of gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / angiogenesis / RNA polymerase II-specific DNA-binding transcription factor binding / cell population proliferation / transcription regulator complex / sequence-specific DNA binding / cell differentiation / receptor complex / DNA-binding transcription factor activity, RNA polymerase II-specific / defense response to bacterium / cadherin binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / Golgi membrane / negative regulation of DNA-templated transcription / calcium ion binding Similarity search - Function Neurogenic locus Notch 3 / Beta-trefoil DNA-binding domain / RBP-J/Cbf11/Cbf12, DNA binding / Beta-trefoil domain superfamily / RBP-J/Cbf11, DNA binding domain superfamily / RBP-Jkappa, IPT domain / Suppressor of hairless-like / Beta-trefoil DNA-binding domain / LAG1, DNA binding / TIG domain ... Neurogenic locus Notch 3 / Beta-trefoil DNA-binding domain / RBP-J/Cbf11/Cbf12, DNA binding / Beta-trefoil domain superfamily / RBP-J/Cbf11, DNA binding domain superfamily / RBP-Jkappa, IPT domain / Suppressor of hairless-like / Beta-trefoil DNA-binding domain / LAG1, DNA binding / TIG domain / LAG1, DNA binding / Beta-trefoil DNA-binding domain / Notch, C-terminal / Domain of unknown function / Notch / Notch, NOD domain / Notch, NODP domain / NOTCH protein / NOTCH protein / NOD / NODP / Notch-like domain superfamily / LNR (Lin-12/Notch) repeat profile. / LNR domain / Notch domain / Domain found in Notch and Lin-12 / EGF-like, conserved site / Human growth factor-like EGF / : / Calcium-binding EGF domain / Ankyrin repeats (many copies) / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / p53-like transcription factor, DNA-binding / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / Ankyrin repeat / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Immunoglobulin E-set / Immunoglobulin-like fold Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.41 Å DetailsAuthors Kovall, R.A. / Gagliani, E. / Hall, D. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) CA178974 United States
CitationJournal : J.Biol.Chem. / Year : 2021Title : PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion.Authors: Landor, S.K.J. / Santio, N.M. / Eccleshall, W.B. / Paramonov, V.M. / Gagliani, E.K. / Hall, D. / Jin, S.B. / Dahlstrom, K.M. / Salminen, T.A. / Rivero-Muller, A. / Lendahl, U. / Kovall, R.A. ... Authors : Landor, S.K.J. / Santio, N.M. / Eccleshall, W.B. / Paramonov, V.M. / Gagliani, E.K. / Hall, D. / Jin, S.B. / Dahlstrom, K.M. / Salminen, T.A. / Rivero-Muller, A. / Lendahl, U. / Kovall, R.A. / Koskinen, P.J. / Sahlgren, C. History Deposition Apr 29, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 31, 2021 Provider : repository / Type : Initial releaseRevision 1.1 Apr 14, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.page_first / _citation.page_last ... _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name Revision 1.2 Jul 14, 2021 Group : Database references / Category : citation / Item : _citation.journal_volumeRevision 1.3 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less