+Open data
-Basic information
Entry | Database: PDB / ID: 6wax | |||||||||
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Title | C-terminal SH2 domain of p120RasGAP | |||||||||
Components | Ras GTPase-activating protein 1 | |||||||||
Keywords | SIGNALING PROTEIN / SH2 domain / RasGAP / phosphopeptide / phosphotyrosine | |||||||||
Function / homology | Function and homology information regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases ...regulation of RNA metabolic process / regulation of actin filament polymerization / potassium channel inhibitor activity / negative regulation of cell adhesion / blood vessel morphogenesis / negative regulation of cell-matrix adhesion / mitotic cytokinesis / ephrin receptor signaling pathway / vasculogenesis / PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases / ruffle / EPHB-mediated forward signaling / phosphotyrosine residue binding / Downstream signal transduction / GTPase activator activity / VEGFR2 mediated cell proliferation / Regulation of RAS by GAPs / GTPase binding / regulation of cell shape / negative regulation of neuron apoptotic process / intracellular signal transduction / signaling receptor binding / GTPase activity / negative regulation of apoptotic process / signal transduction / plasma membrane / cytoplasm / cytosol Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.5 Å | |||||||||
Authors | Jaber Chehayeb, R. / Wang, J. / Stiegler, A.L. / Boggon, T.J. | |||||||||
Funding support | United States, 2items
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Citation | Journal: J.Biol.Chem. / Year: 2020 Title: The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. Authors: Jaber Chehayeb, R. / Wang, J. / Stiegler, A.L. / Boggon, T.J. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6wax.cif.gz | 113.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6wax.ent.gz | 85.9 KB | Display | PDB format |
PDBx/mmJSON format | 6wax.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/wa/6wax ftp://data.pdbj.org/pub/pdb/validation_reports/wa/6wax | HTTPS FTP |
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-Related structure data
Related structure data | 6wayC 1d4tS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | |
Experimental dataset #1 | Data reference: 10.15785/SBGRID/774 / Data set type: diffraction image data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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