Entry Database : PDB / ID : 6w25 Structure visualization Downloads & linksTitle Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with SHU9119 ComponentsMelanocortin receptor 4,GlgA glycogen synthase,Melanocortin receptor 4 SHU9119 DetailsKeywords MEMBRANE PROTEIN / Melanocortin-4 Receptor / Ca++ cofactor / SHU9119 / GPCR / PGS fusion / LCPFunction / homology Function and homology informationFunction Domain/homology Component
regulation of eating behavior / melanocyte-stimulating hormone receptor activity / response to melanocyte-stimulating hormone / melanocortin receptor activity / glycogen (starch) synthase activity / regulation of grooming behavior / energy reserve metabolic process / regulation of metabolic process / neuropeptide binding / feeding behavior ... regulation of eating behavior / melanocyte-stimulating hormone receptor activity / response to melanocyte-stimulating hormone / melanocortin receptor activity / glycogen (starch) synthase activity / regulation of grooming behavior / energy reserve metabolic process / regulation of metabolic process / neuropeptide binding / feeding behavior / glycogen biosynthetic process / insulin secretion / negative regulation of feeding behavior / diet induced thermogenesis / peptide hormone binding / positive regulation of bone resorption / Peptide ligand-binding receptors / response to insulin / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / G alpha (s) signalling events / ubiquitin protein ligase binding / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function Melanocortin 4 receptor / Melanocortin receptor 3-5 / Melanocortin/ACTH receptor / Glycosyl transferases group 1 / Bacterial/plant glycogen synthase / Starch synthase, catalytic domain / Starch synthase catalytic domain / Glycosyl transferases group 1 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. ... Melanocortin 4 receptor / Melanocortin receptor 3-5 / Melanocortin/ACTH receptor / Glycosyl transferases group 1 / Bacterial/plant glycogen synthase / Starch synthase, catalytic domain / Starch synthase catalytic domain / Glycosyl transferases group 1 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) Similarity search - Domain/homologyBiological species Homo sapiens (human)Pyrococcus abyssi (archaea)synthetic construct (others) Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.75 Å DetailsAuthors Yu, J. / Gimenez, L.E. / Hernandez, C.C. / Wu, Y. / Wein, A.H. / Han, G.W. / McClary, K. / Mittal, S.R. / Burdsall, K. / Stauch, B. ...Yu, J. / Gimenez, L.E. / Hernandez, C.C. / Wu, Y. / Wein, A.H. / Han, G.W. / McClary, K. / Mittal, S.R. / Burdsall, K. / Stauch, B. / Wu, L. / Stevens, S.N. / Peisley, A. / Williams, S.Y. / Chen, V. / Millhauser, G.L. / Zhao, S. / Cone, R.D. / Stevens, R.C. CitationJournal : Science / Year : 2020Title : Determination of the melanocortin-4 receptor structure identifies Ca2+as a cofactor for ligand binding.Authors: Yu, J. / Gimenez, L.E. / Hernandez, C.C. / Wu, Y. / Wein, A.H. / Han, G.W. / McClary, K. / Mittal, S.R. / Burdsall, K. / Stauch, B. / Wu, L. / Stevens, S.N. / Peisley, A. / Williams, S.Y. / ... Authors : Yu, J. / Gimenez, L.E. / Hernandez, C.C. / Wu, Y. / Wein, A.H. / Han, G.W. / McClary, K. / Mittal, S.R. / Burdsall, K. / Stauch, B. / Wu, L. / Stevens, S.N. / Peisley, A. / Williams, S.Y. / Chen, V. / Millhauser, G.L. / Zhao, S. / Cone, R.D. / Stevens, R.C. History Deposition Mar 4, 2020 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 29, 2020 Provider : repository / Type : Initial releaseRevision 1.1 May 6, 2020 Group : Database references / Refinement descriptionCategory : citation / citation_author / pdbx_refine_tls_groupItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID Revision 2.0 Sep 9, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Database references / Derived calculations / Structure summary Category : atom_site / pdbx_poly_seq_scheme ... atom_site / pdbx_poly_seq_scheme / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / pdbx_validate_close_contact / struct_conn / struct_conn_type / struct_ref_seq / struct_site / struct_site_gen Item : _atom_site.auth_seq_id / _pdbx_poly_seq_scheme.pdb_seq_num ... _atom_site.auth_seq_id / _pdbx_poly_seq_scheme.pdb_seq_num / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_unobs_or_zero_occ_atoms.auth_seq_id / _pdbx_validate_close_contact.auth_seq_id_1 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_site.pdbx_auth_seq_id / _struct_site_gen.auth_seq_id Revision 2.1 Oct 18, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 2.2 Nov 15, 2023 Group : Data collection / Derived calculations / Category : chem_comp_atom / chem_comp_bond / struct_connItem : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 / _struct_conn.pdbx_leaving_atom_flag
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