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- PDB-6vyp: Crystal structure of the LSD1/CoREST histone demethylase bound to... -

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Basic information

Entry
Database: PDB / ID: 6vyp
TitleCrystal structure of the LSD1/CoREST histone demethylase bound to its nucleosome substrate
Components
  • (DNA (191-MER)) x 2
  • Histone H2A type 1
  • Histone H2B 1.1
  • Histone H3
  • Histone H4
  • Lysine-specific histone demethylase 1A
  • REST corepressor 1
KeywordsNUCLEAR PROTEIN/DNA / epigenetics / histone modifications / histone demethylation / NUCLEAR PROTEIN / NUCLEAR PROTEIN-DNA complex
Function / homology
Function and homology information


positive regulation of megakaryocyte differentiation / guanine metabolic process / negative regulation of transcription initiation-coupled chromatin remodeling / protein demethylase activity / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / neuron maturation / muscle cell development ...positive regulation of megakaryocyte differentiation / guanine metabolic process / negative regulation of transcription initiation-coupled chromatin remodeling / protein demethylase activity / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / telomeric repeat-containing RNA binding / histone H3K4 demethylase activity / neuron maturation / muscle cell development / positive regulation of neural precursor cell proliferation / negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator / MRF binding / regulation of androgen receptor signaling pathway / DNA repair complex / nuclear androgen receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of double-strand break repair via homologous recombination / positive regulation of neuroblast proliferation / DNA repair-dependent chromatin remodeling / positive regulation of stem cell proliferation / histone H3K9 demethylase activity / histone deacetylase complex / negative regulation of DNA damage response, signal transduction by p53 class mediator / histone methyltransferase complex / histone demethylase activity / positive regulation of cell size / positive regulation of epithelial to mesenchymal transition / response to fungicide / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / transcription repressor complex / epigenetic regulation of gene expression / cellular response to cAMP / positive regulation of protein ubiquitination / Regulation of PTEN gene transcription / erythrocyte differentiation / HDACs deacetylate histones / promoter-specific chromatin binding / cellular response to gamma radiation / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / HDMs demethylate histones / positive regulation of neuron projection development / cerebral cortex development / protein modification process / p53 binding / cellular response to UV / structural constituent of chromatin / transcription corepressor activity / heterochromatin formation / nucleosome / flavin adenine dinucleotide binding / nucleosome assembly / regulation of protein localization / positive regulation of cold-induced thermogenesis / Factors involved in megakaryocyte development and platelet production / chromatin organization / transcription regulator complex / Estrogen-dependent gene expression / DNA-binding transcription factor binding / Potential therapeutics for SARS / RNA polymerase II-specific DNA-binding transcription factor binding / transcription coactivator activity / oxidoreductase activity / chromosome, telomeric region / protein heterodimerization activity / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / enzyme binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / nucleoplasm / identical protein binding / nucleus
Similarity search - Function
: / Helical region in REST corepressor / : / Histone lysine-specific demethylase / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / SWIRM domain / SWIRM domain ...: / Helical region in REST corepressor / : / Histone lysine-specific demethylase / ELM2 domain / ELM2 domain / ELM2 domain profile. / ELM2 / SWIRM domain / SWIRM domain / SWIRM domain profile. / : / SANT domain profile. / Amine oxidase / Flavin containing amine oxidoreductase / SANT domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / : / Histone H2B signature. / Histone H2A conserved site / Histone H2A signature. / Histone H2B / Histone H2B / Histone H2A, C-terminal domain / C-terminus of histone H2A / Histone 2A / Histone H2A / TATA box binding protein associated factor / TATA box binding protein associated factor (TAF), histone-like fold domain / Histone H4, conserved site / Histone H4 signature. / Histone H4 / Histone H4 / CENP-T/Histone H4, histone fold / Centromere kinetochore component CENP-T histone fold / Homeobox-like domain superfamily / Histone H3 signature 1. / Histone H3 signature 2. / FAD/NAD(P)-binding domain superfamily / Histone H3 / Histone H3/CENP-A / Histone H2A/H2B/H3 / Core histone H2A/H2B/H3/H4 domain / Histone-fold / Winged helix-like DNA-binding domain superfamily
Similarity search - Domain/homology
FLAVIN-ADENINE DINUCLEOTIDE / DNA / DNA (> 10) / DNA (> 100) / Histone H3 / Lysine-specific histone demethylase 1A / Histone H2B 1.1 / Histone H2A type 1 / Histone H4 / Histone H3.2 / REST corepressor 1
Similarity search - Component
Biological speciesXenopus laevis (African clawed frog)
synthetic construct (others)
Homo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.99 Å
AuthorsKim, S. / Zhu, J. / Eek, P. / Yennawar, N. / Song, T.
Funding support United States, 3items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM088236 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM111651 United States
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM127034 United States
CitationJournal: Mol.Cell / Year: 2020
Title: Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate.
Authors: Kim, S.A. / Zhu, J. / Yennawar, N. / Eek, P. / Tan, S.
History
DepositionFeb 27, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0May 27, 2020Provider: repository / Type: Initial release
Revision 1.1Jun 17, 2020Group: Database references / Category: citation / Item: _citation.journal_volume / _citation.page_first
Revision 1.2Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Histone H3
B: Histone H4
C: Histone H2A type 1
D: Histone H2B 1.1
E: Histone H3
F: Histone H4
G: Histone H2A type 1
H: Histone H2B 1.1
I: DNA (191-MER)
J: DNA (191-MER)
a: Histone H3
b: Histone H4
c: Histone H2A type 1
d: Histone H2B 1.1
e: Histone H3
f: Histone H4
g: Histone H2A type 1
h: Histone H2B 1.1
M: Lysine-specific histone demethylase 1A
N: REST corepressor 1
m: Lysine-specific histone demethylase 1A
n: REST corepressor 1
K: Lysine-specific histone demethylase 1A
L: REST corepressor 1
k: Lysine-specific histone demethylase 1A
l: REST corepressor 1
i: DNA (191-MER)
j: DNA (191-MER)
hetero molecules


Theoretical massNumber of molelcules
Total (without water)830,06732
Polymers826,92528
Non-polymers3,1424
Water00
1
A: Histone H3
B: Histone H4
C: Histone H2A type 1
D: Histone H2B 1.1
E: Histone H3
F: Histone H4
G: Histone H2A type 1
H: Histone H2B 1.1
I: DNA (191-MER)
J: DNA (191-MER)
M: Lysine-specific histone demethylase 1A
N: REST corepressor 1
K: Lysine-specific histone demethylase 1A
L: REST corepressor 1
hetero molecules


Theoretical massNumber of molelcules
Total (without water)415,03416
Polymers413,46314
Non-polymers1,5712
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
a: Histone H3
b: Histone H4
c: Histone H2A type 1
d: Histone H2B 1.1
e: Histone H3
f: Histone H4
g: Histone H2A type 1
h: Histone H2B 1.1
m: Lysine-specific histone demethylase 1A
n: REST corepressor 1
k: Lysine-specific histone demethylase 1A
l: REST corepressor 1
i: DNA (191-MER)
j: DNA (191-MER)
hetero molecules


Theoretical massNumber of molelcules
Total (without water)415,03416
Polymers413,46314
Non-polymers1,5712
Water0
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)103.771, 335.770, 174.633
Angle α, β, γ (deg.)90.000, 91.070, 90.000
Int Tables number4
Space group name H-MP1211
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11(chain A and (resid 41 through 51 or resid 53...
21(chain E and (resid 41 through 51 or resid 53...
31(chain a and (resid 41 through 51 or resid 53...
41(chain e and (resid 41 through 51 or resid 53...
12(chain B and resid 32 through 101)
22(chain F and resid 32 through 101)
32(chain f and resid 32 through 101)
13(chain C and (resid 16 through 41 or resid 43...
23(chain G and (resid 16 through 41 or resid 43...
33(chain c and (resid 16 through 41 or resid 43...
43(chain g and (resid 16 through 41 or resid 43...
14(chain D and (resid 32 through 88 or resid 90 through 121))
24(chain H and (resid 32 through 88 or resid 90 through 121))
34(chain d and (resid 32 through 88 or resid 90 through 121))
44(chain h and (resid 32 through 88 or resid 90 through 121))
15chain I
25chain i
16chain J
26chain j
17(chain L and (resid 310 through 347 or resid 349...
27(chain N and (resid 310 through 347 or resid 349...
18(chain M and (resid 171 through 272 or resid 275...
28(chain m and (resid 171 through 272 or resid 275...

NCS domain segments:
Dom-IDComponent-IDEns-IDSelection detailsAuth asym-IDAuth seq-ID
111(chain A and (resid 41 through 51 or resid 53...A41 - 51
121(chain A and (resid 41 through 51 or resid 53...A53 - 62
131(chain A and (resid 41 through 51 or resid 53...A64 - 114
141(chain A and (resid 41 through 51 or resid 53...A116 - 132
211(chain E and (resid 41 through 51 or resid 53...E41 - 51
221(chain E and (resid 41 through 51 or resid 53...E53 - 62
231(chain E and (resid 41 through 51 or resid 53...E64 - 114
241(chain E and (resid 41 through 51 or resid 53...E116 - 132
311(chain a and (resid 41 through 51 or resid 53...a41 - 51
321(chain a and (resid 41 through 51 or resid 53...a53 - 62
331(chain a and (resid 41 through 51 or resid 53...a64 - 114
341(chain a and (resid 41 through 51 or resid 53...a116 - 132
411(chain e and (resid 41 through 51 or resid 53...e41 - 51
421(chain e and (resid 41 through 51 or resid 53...e53 - 62
431(chain e and (resid 41 through 51 or resid 53...e64 - 114
441(chain e and (resid 41 through 51 or resid 53...e116 - 132
112(chain B and resid 32 through 101)B32 - 101
212(chain F and resid 32 through 101)F32 - 101
312(chain f and resid 32 through 101)f32 - 101
113(chain C and (resid 16 through 41 or resid 43...C16 - 41
123(chain C and (resid 16 through 41 or resid 43...C43 - 49
133(chain C and (resid 16 through 41 or resid 43...C51 - 76
143(chain C and (resid 16 through 41 or resid 43...C78 - 117
213(chain G and (resid 16 through 41 or resid 43...G16 - 41
223(chain G and (resid 16 through 41 or resid 43...G43 - 49
233(chain G and (resid 16 through 41 or resid 43...G51 - 76
243(chain G and (resid 16 through 41 or resid 43...G78 - 117
313(chain c and (resid 16 through 41 or resid 43...c16 - 41
323(chain c and (resid 16 through 41 or resid 43...c43 - 49
333(chain c and (resid 16 through 41 or resid 43...c51 - 76
343(chain c and (resid 16 through 41 or resid 43...c78 - 117
413(chain g and (resid 16 through 41 or resid 43...g16 - 41
423(chain g and (resid 16 through 41 or resid 43...g43 - 49
433(chain g and (resid 16 through 41 or resid 43...g51 - 76
443(chain g and (resid 16 through 41 or resid 43...g78 - 117
114(chain D and (resid 32 through 88 or resid 90 through 121))D32 - 88
124(chain D and (resid 32 through 88 or resid 90 through 121))D90 - 121
214(chain H and (resid 32 through 88 or resid 90 through 121))H32 - 88
224(chain H and (resid 32 through 88 or resid 90 through 121))H90 - 121
314(chain d and (resid 32 through 88 or resid 90 through 121))d32 - 88
324(chain d and (resid 32 through 88 or resid 90 through 121))d90 - 121
414(chain h and (resid 32 through 88 or resid 90 through 121))h32 - 88
424(chain h and (resid 32 through 88 or resid 90 through 121))h90 - 121
115chain II-95 - 95
215chain ii-95 - 95
116chain JJ-95 - 95
216chain jj-95 - 95
117(chain L and (resid 310 through 347 or resid 349...L310 - 347
127(chain L and (resid 310 through 347 or resid 349...L349 - 370
137(chain L and (resid 310 through 347 or resid 349...L372 - 381
147(chain L and (resid 310 through 347 or resid 349...L383 - 425
157(chain L and (resid 310 through 347 or resid 349...L428 - 440
217(chain N and (resid 310 through 347 or resid 349...N310 - 347
227(chain N and (resid 310 through 347 or resid 349...N349 - 370
237(chain N and (resid 310 through 347 or resid 349...N308 - 440
247(chain N and (resid 310 through 347 or resid 349...N383 - 425
257(chain N and (resid 310 through 347 or resid 349...N428 - 440
118(chain M and (resid 171 through 272 or resid 275...M171 - 272
128(chain M and (resid 171 through 272 or resid 275...M275
138(chain M and (resid 171 through 272 or resid 275...M277 - 279
148(chain M and (resid 171 through 272 or resid 275...M281 - 472
158(chain M and (resid 171 through 272 or resid 275...M484 - 509
168(chain M and (resid 171 through 272 or resid 275...M511 - 52
178(chain M and (resid 171 through 272 or resid 275...M526 - 607
188(chain M and (resid 171 through 272 or resid 275...M613 - 900
218(chain m and (resid 171 through 272 or resid 275...m171 - 272
228(chain m and (resid 171 through 272 or resid 275...m275
238(chain m and (resid 171 through 272 or resid 275...m277
248(chain m and (resid 171 through 272 or resid 275...m475
258(chain m and (resid 171 through 272 or resid 275...m475 - 482
268(chain m and (resid 171 through 272 or resid 275...m0
278(chain m and (resid 171 through 272 or resid 275...m511 - 521
288(chain m and (resid 171 through 272 or resid 275...m526 - 607
298(chain m and (resid 171 through 272 or resid 275...m613 - 900

NCS ensembles :
ID
1
2
3
4
5
6
7
8

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Components

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Protein , 6 types, 24 molecules AEaeBFbfCGcgDHdhMmKkNnLl

#1: Protein
Histone H3


Mass: 15305.945 Da / Num. of mol.: 4 / Mutation: K4M
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Gene: XELAEV_18002543mg / Production host: Escherichia coli (E. coli) / References: UniProt: A0A310TTQ1, UniProt: P84233*PLUS
#2: Protein
Histone H4


Mass: 11263.231 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P62799
#3: Protein
Histone H2A type 1


Mass: 13978.241 Da / Num. of mol.: 4 / Mutation: G99R/A123S
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P06897
#4: Protein
Histone H2B 1.1 / H2B1.1


Mass: 13524.752 Da / Num. of mol.: 4 / Mutation: S32T
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Xenopus laevis (African clawed frog) / Production host: Escherichia coli (E. coli) / References: UniProt: P02281
#7: Protein
Lysine-specific histone demethylase 1A / BRAF35-HDAC complex protein BHC110 / Flavin-containing amine oxidase domain-containing protein 2


Mass: 75732.609 Da / Num. of mol.: 4 / Mutation: R608A/N717A/D721A
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: KDM1A, AOF2, KDM1, KIAA0601, LSD1 / Production host: Escherichia coli (E. coli) / References: UniProt: O60341, Oxidoreductases
#8: Protein
REST corepressor 1 / Protein CoREST


Mass: 17956.426 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: RCOR1, KIAA0071, RCOR / Production host: Escherichia coli (E. coli) / References: UniProt: Q9UKL0

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DNA chain , 2 types, 4 molecules IiJj

#5: DNA chain DNA (191-MER)


Mass: 58694.375 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Escherichia coli (E. coli)
#6: DNA chain DNA (191-MER)


Mass: 59245.719 Da / Num. of mol.: 2
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Escherichia coli (E. coli)

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Non-polymers , 1 types, 4 molecules

#9: Chemical
ChemComp-FAD / FLAVIN-ADENINE DINUCLEOTIDE


Mass: 785.550 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C27H33N9O15P2 / Comment: FAD*YM

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Details

Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.98 Å3/Da / Density % sol: 69.11 %
Crystal growTemperature: 277 K / Method: microbatch / pH: 7.5
Details: 25 mM HEPES pH7.5, 75 mM triammonium citrate, 10% PEG2000-MME, Modified Microbatch under oil

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 24-ID-E / Wavelength: 0.97918 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Apr 18, 2017
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97918 Å / Relative weight: 1
ReflectionResolution: 4.99→20.17 Å / Num. obs: 50839 / % possible obs: 98.2 % / Redundancy: 3.5 % / CC1/2: 0.998 / Rmerge(I) obs: 0.079 / Rpim(I) all: 0.05 / Rrim(I) all: 0.093 / Net I/σ(I): 8.1 / Num. measured all: 175610 / Scaling rejects: 9
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. measured allNum. unique obsCC1/2Rpim(I) allRrim(I) allNet I/σ(I) obs% possible all
4.99-5.153.61.341713747420.3520.8221.5750.999.9
19.96-20.172.80.03274260.9980.0210.03827.73.1

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Processing

Software
NameVersionClassification
PHENIX1.15.2_3472refinement
SCALA0.5.23data scaling
PDB_EXTRACT3.25data extraction
MOSFLMdata reduction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 3LZ0

3lz0


Resolution: 4.99→20.17 Å / SU ML: 0.91 / Cross valid method: THROUGHOUT / σ(F): 1.34 / Phase error: 34.58 / Stereochemistry target values: ML
RfactorNum. reflection% reflection
Rfree0.2774 1978 3.9 %
Rwork0.2291 48682 -
obs0.2309 50660 99.33 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso max: 918.14 Å2 / Biso mean: 415.2764 Å2 / Biso min: 179.53 Å2
Refinement stepCycle: final / Resolution: 4.99→20.17 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms37122 15662 212 0 52996
Biso mean--411.01 --
Num. residues----5478
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00255591
X-RAY DIFFRACTIONf_angle_d0.46878550
X-RAY DIFFRACTIONf_dihedral_angle_d18.91530765
X-RAY DIFFRACTIONf_chiral_restr0.0338887
X-RAY DIFFRACTIONf_plane_restr0.0037365
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11A1060X-RAY DIFFRACTION2.17TORSIONAL
12E1060X-RAY DIFFRACTION2.17TORSIONAL
13a1060X-RAY DIFFRACTION2.17TORSIONAL
14e1060X-RAY DIFFRACTION2.17TORSIONAL
21B651X-RAY DIFFRACTION2.17TORSIONAL
22F651X-RAY DIFFRACTION2.17TORSIONAL
23f651X-RAY DIFFRACTION2.17TORSIONAL
31C1176X-RAY DIFFRACTION2.17TORSIONAL
32G1176X-RAY DIFFRACTION2.17TORSIONAL
33c1176X-RAY DIFFRACTION2.17TORSIONAL
34g1176X-RAY DIFFRACTION2.17TORSIONAL
41D1060X-RAY DIFFRACTION2.17TORSIONAL
42H1060X-RAY DIFFRACTION2.17TORSIONAL
43d1060X-RAY DIFFRACTION2.17TORSIONAL
44h1060X-RAY DIFFRACTION2.17TORSIONAL
51I3814X-RAY DIFFRACTION2.17TORSIONAL
52i3814X-RAY DIFFRACTION2.17TORSIONAL
61J3814X-RAY DIFFRACTION2.17TORSIONAL
62j3814X-RAY DIFFRACTION2.17TORSIONAL
71L736X-RAY DIFFRACTION2.17TORSIONAL
72N736X-RAY DIFFRACTION2.17TORSIONAL
81M3908X-RAY DIFFRACTION2.17TORSIONAL
82m3908X-RAY DIFFRACTION2.17TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0 / Total num. of bins used: 14

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkNum. reflection all% reflection obs (%)
4.9901-5.11290.4047990.35483396349597
5.1129-5.24880.39311980.354934303628100
5.2488-5.40040.3276990.346435433642100
5.4004-5.57120.37411980.348133933591100
5.5712-5.76580.3474990.348435673666100
5.7658-5.99080.37271980.340933913589100
5.9908-6.25570.3749980.33235323630100
6.2557-6.57470.3471990.32335443643100
6.5747-6.97060.35291980.306934523650100
6.9706-7.48320.3226990.27735353634100
7.4832-8.19010.28051980.232134243622100
8.1901-9.2730.2639990.212835523651100
9.273-11.32760.19411980.16853401359998
11.3276-20.16980.2709980.16163522362098
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
13.02630.5261-2.58925.5652.50943.33021.26430.3082-0.13580.3621.1105-0.4861-0.07882.6612-1.80041.26850.0029-0.36392.32730.63372.67532.610944.9766131.5927
27.94884.89272.87728.73122.04213.4732-1.3292-0.26111.4370.4339-0.87010.68160.74740.07452.56241.92040.0033-0.1594.0917-0.13092.418639.315748.802986.593
31.39783.38943.13298.8598.27368.11022.6707-0.94432.41942.3181-0.44871.7317-0.7061-1.39430.01481.40360.4280.83273.58430.5422.371728.699155.442591.2236
48.1364-8.29162.52019.294-4.28054.32582.442-1.77782.13434.4365-4.6979-2.614-5.3821-2.31911.98963.2967-0.3619-0.12493.7112-0.47241.600940.903152.2437102.1375
53.75393.4617-3.58927.0193-7.95589.04822.6163-0.2873-1.37071.3822-2.6234-2.6614-5.3804-1.7179-2.93772.56020.44330.39762.4547-0.27865.086940.232151.545478.195
62.0513-0.5084-2.46953.1922-1.67744.5649-0.44571.63271.4115-0.7686-0.0360.97541.66330.97273.74022.6087-0.2583-1.35763.487-0.71352.353531.459945.137163.1396
72.3395-2.24834.6048.2275-5.97479.4583-3.61236.632-0.05475.00713.4786-7.8112-0.19554.4086-1.27772.39980.57790.20733.6013-0.73663.251140.17139.744472.0911
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945.92031.21724.86970.77630.43864.5787-1.4444-0.2894-1.56940.5969-0.24811.25650.27290.471-6.93521.70872.07120.0067.66350.17665.919431.9248105.35104.128
957.03522.7002-6.31975.1297-2.38425.33760.6709-1.81272.21120.348-0.625-0.6858-0.82282.39740.12093.23680.5481-0.51773.2481-0.33942.732928.597378.708793.8882
963.24982.43463.75356.94398.17119.9106-0.3855-0.9981-3.5022-5.64280.0198-5.4411-1.42711.40750.41942.81781.08470.51753.613-0.36724.021736.202674.703281.3747
979.55543.26284.25448.83758.43346.3065-0.62040.21642.5320.45940.83291.218-1.645-0.2345-0.44154.9851-0.31040.36433.69840.15784.090373.9663-65.3621-61.7688
983.5823-2.0177-2.4776-0.0561.45480.127-0.4425-1.03080.61690.39350.37730.2322-0.18111.17860.24474.06540.45350.20174.3423-0.17533.96320.4907-77.9299-36.0377
991.83472.2809-2.40221.7527-1.40513.2141-0.7561-0.82550.34910.48630.2228-1.4099-0.9082-0.05270.45883.85240.3354-0.23543.9334-0.09044.254560.9636-87.7151-57.9266
1007.06481.14350.35891.1643-0.80230.22182.53971.86232.7798-1.46780.19011.1890.29860.9099-2.48952.69050.70680.26912.866-0.64343.477222.0593-85.1504-24.2143
1015.20111.64140.41027.2216.5885.4788-0.87761.6425-0.1535-0.078-0.86230.61351.44551.11841.96852.7761-0.208-0.30563.1459-0.03892.2877-20.2581-52.2624-5.5897
1026.2662.95224.54823.68466.35659.7277-0.11162.38332.2338-0.80970.36921.9179-1.5479-0.0718-0.31016.25410.51390.87414.73381.2717.51515.869862.7332173.6204
1035.1087-5.5643-2.46378.95882.29991.35651.5044-0.93492.7888-0.3108-2.04172.34370.44880.9574-0.40196.2554-0.57521.01744.73560.18043.598934.243646.4872178.0206
1046.7589-3.1382-8.2818-0.59042.87994.2529-0.312-1.8833-2.22010.9935-0.63420.2896-1.72590.34370.32115.96850.3857-0.78275.49-0.02513.496674.548219.5541141.1086
1054.693-3.9903-4.77120.6544.79971.88860.1444-1.94161.84345.31150.20336.01153.3285-1.26650.50246.49760.30790.36854.0267-0.14352.959235.492442.1672176.093
1065.089-0.1609-4.4579-0.73970.00883.10540.7582-2.1912.85311.02710.04211.8308-0.56390.2016-0.93366.7430.02720.79014.8623-0.07044.596922.279741.5801191.1066
1075.1551-6.27451.63689.03260.85035.20410.24613.395-0.6731-3.047-0.07254.58180.5193-1.9099-0.80354.894-0.02230.17525.36750.30026.49630.722146.3913176.786
1085.4627-4.4624.20095.5506-4.26863.5306-3.4077-5.89091.5204-2.36182.1152-3.1693.2223.71740.70233.15580.18411.09235.67810.26123.771341.123134.6386156.3171
1099.5248-1.3919-6.61590.62411.69965.8528-4.13772.492-0.8806-10.05320.0134.4046.5956-0.74465.07048.5084-0.9421-0.20393.4829-0.35373.207336.581421.2528160.1447
1105.09224.58323.85575.00973.70486.22621.7617-1.41995.28555.73110.68744.33648.1933-0.5651-1.93537.018-1.37050.79724.229-1.18385.195136.114614.8132168.8859
1119.2277-1.1555-8.04720.5271.46027.08464.4546-1.6998-4.01530.8436-0.39511.9221-3.5689-1.23-3.19913.0111.20010.00863.83371.16713.511762.326913.4791159.007
1122.1057-3.57561.86039.2683-2.93597.97035.23745.5574-4.6979-3.945-3.29494.0369-2.7678-0.593-0.88164.3221.1981-0.71524.8254-1.47243.83489.247317.5952141.1833
1133.87033.25420.55897.59763.14781.99653.0169-5.10620.50490.41510.2564-0.405-2.7451-1.4051-3.84514.1590.741-0.58636.4049-0.47455.157893.899329.6072118.0484
1140.9551-2.5528-1.51976.7444.00952.39521.3851-4.3625-1.42553.31731.0739-3.98022.22294.78340.76952.83390.3579-1.67565.62940.57123.096987.066219.55109.5215
1157.13126.6854-2.42798.288-1.6124.820.7516-2.5864.73134.0333-1.93056.65992.9483.43661.51284.02050.52760.00123.76180.05424.25883.389528.1355112.2976
1164.0734-6.1106-4.33089.24286.98668.05531.32057.541-1.6225-2.4342-0.9587-3.9972-1.255-0.3915-1.72432.34460.39-0.66785.2896-0.45.348381.118223.807999.001
1175.5269-3.8528-4.29014.37483.67054.4146-0.8609-0.58393.8149-0.32714.7198-0.46033.91240.3369-4.5722.8189-0.0167-0.39024.70810.82434.058674.849815.7479107.6189
1184.1034-3.0467-4.37674.52211.93754.39421.6397-1.0936-3.48022.5843-0.1683.1584-1.7641-1.2484-1.52926.6157-0.50620.01265.71080.60487.134-40.409-36.9321-83.0677
1199.99141.69953.40553.91032.96972.05691.40030.9464-4.2789-0.1797-0.44232.34072.5327-0.8535-0.96625.67140.4698-0.24415.55760.21485.1099-16.3088-20.6346-95.5041
1206.58592.836910.7657-0.97961.22314.87961.59220.17580.5908-2.5802-0.6614-0.31541.6394-1.8397-1.0357.36-0.27240.86315.9745-0.00575.359426.47047.5967-54.2436
1212.7688-1.24534.65120.5376-2.53837.44510.1446.75731.4068-1.4257-1.4517-2.3902-2.73471.1764-4.46977.2585-1.76261.17257.10820.2285-2.05862.5695-5.3579-89.2395
1229.90442.03331.31043.319-0.6689-0.3294-0.09242.74-2.0017-1.10980.02111.78081.28391.06690.00047.31030.672-0.72276.0721-0.64385.5179-23.3802-15.6518-103.0844
1239.44129.7116-0.78349.8949-0.82695.9137-0.50930.3131-0.4373-1.45790.3680.9323-3.421-0.95890.35617.66330.39050.67355.418-0.30895.4711-45.6002-18.6086-90.7499
1241.9935-4.34715.78057.62053.45929.59960.9428-6.234312.63692.4715-2.61495.80383.1479-8.37682.12683.8776-0.1576-0.52827.24851.09047.13790.0305-3.8296-60.6767
1257.2124-3.85464.4821.7614-0.01154.6769-3.4456-1.81311.2859-1.66371.9245-2.5335-1.02582.4413-0.1225.6432-1.12960.44682.60050.6692.483516.293211.7257-68.9821
1267.547-2.7923-2.60394.01145.68797.32082.76540.0283-0.8261-0.72891.10950.4004-0.9555-2.3709-3.95744.2467-0.28020.83784.35840.45914.90434.44173.3485-22.492
1277.78915.51090.18882.98480.12170.00411.091-0.6293-0.9694-2.81810.8557-0.56913.83475.4784-1.41128.31571.9917-0.45275.3382-0.19115.133537.543-61.7699-65.2345
1283.11075.53624.2842.90776.69855.5057-3.64620.69030.9611-1.5623-1.00293.381-0.78241.79024.25283.27920.239-0.16585.20990.98576.16439.0054-40.2081-1.5644
1294.251-0.3154-0.83992.53680.08244.4688-0.2742-2.8029-0.07840.98030.2197-0.2594-0.3406-1.04830.1244.2497-0.0370.2933.9459-0.13614.6462-8.1432-13.384332.0936
1305.1712-6.8573-1.94839.9251.71722.91641.20131.70411.2386-2.3497-0.9291-0.05140.22310.3659-0.58064.56480.29440.40715.1655-0.63633.6951-9.0369-31.403-24.4197
1310.54722.1010.17348.65742.4996.26060.8073-0.38690.0042-0.83390.0692-2.8542-2.11990.7885-1.28722.2381-0.1274-0.04674.77270.2064.482135.0908-4.68446.6991
1325.93-0.649-0.61281.39542.21444.68481.0966-3.0124-0.14961.4969-1.69780.15910.3487-4.02550.67513.9565-0.02580.14573.8916-0.19053.7089-24.27569.63313.902
1338.9347-1.8184-5.13531.35193.52545.6173-0.3519-0.373-3.1098-2.5695-1.87470.7072-5.53590.70741.36356.63880.3337-0.4334.49110.67645.2339-11.9717-29.2872-68.7218
1346.9013-7.6449-6.85756.52697.016.3752-1.2723-1.2988-4.2804-2.2922-0.73861.776-1.86720.11821.77237.60690.06480.00446.22210.86066.203-6.4452-38.3626-84.527
1355.8148-4.2934-4.84634.25067.36822.156-1.38610.24641.5561-1.9973-1.60833.4179-4.7964-3.5684-0.35284.753-0.0676-0.70115.90191.08043.9879-28.0728-7.9678-28.8096
1365.0028-0.4515-2.10954.42911.46433.36150.7608-0.66731.1261-0.055-0.1596-1.5906-0.41910.5594-0.55353.7563-0.18230.04754.31970.72193.835912.4179-1.68517.1197
1376.0814-1.32880.49634.29990.92365.4699-0.1638-0.8503-0.06890.3898-0.0612-0.6814-0.65870.16910.16523.2469-0.31780.51463.14610.58424.26052.1922-22.539415.1446
1387.48655.29087.29324.85757.44461.9643-5.7972.33633.27451.6466-4.06511.7198-0.7377-1.5867.23245.96330.23171.08753.71950.93977.403435.5498-56.2265-44.8315
1392.04754.26742.76918.21735.5913.66521.78630.574-5.9635-5.0978-2.78527.50082.48193.533.34487.29742.2158-0.15216.5241-0.20145.552739.3607-66.4427-78.2477
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 3 through 56 )A3 - 56
2X-RAY DIFFRACTION2chain 'A' and (resid 57 through 134 )A57 - 134
3X-RAY DIFFRACTION3chain 'B' and (resid 21 through 40 )B21 - 40
4X-RAY DIFFRACTION4chain 'B' and (resid 41 through 49 )B41 - 49
5X-RAY DIFFRACTION5chain 'B' and (resid 50 through 75 )B50 - 75
6X-RAY DIFFRACTION6chain 'B' and (resid 76 through 82 )B76 - 82
7X-RAY DIFFRACTION7chain 'B' and (resid 83 through 92 )B83 - 92
8X-RAY DIFFRACTION8chain 'B' and (resid 93 through 101 )B93 - 101
9X-RAY DIFFRACTION9chain 'C' and (resid 16 through 37 )C16 - 37
10X-RAY DIFFRACTION10chain 'C' and (resid 38 through 46 )C38 - 46
11X-RAY DIFFRACTION11chain 'C' and (resid 47 through 79 )C47 - 79
12X-RAY DIFFRACTION12chain 'C' and (resid 80 through 89 )C80 - 89
13X-RAY DIFFRACTION13chain 'C' and (resid 90 through 111 )C90 - 111
14X-RAY DIFFRACTION14chain 'C' and (resid 112 through 118 )C112 - 118
15X-RAY DIFFRACTION15chain 'D' and (resid 30 through 34 )D30 - 34
16X-RAY DIFFRACTION16chain 'D' and (resid 35 through 52 )D35 - 52
17X-RAY DIFFRACTION17chain 'D' and (resid 53 through 87 )D53 - 87
18X-RAY DIFFRACTION18chain 'D' and (resid 88 through 121 )D88 - 121
19X-RAY DIFFRACTION19chain 'E' and (resid 1 through 44 )E1 - 44
20X-RAY DIFFRACTION20chain 'E' and (resid 45 through 132 )E45 - 132
21X-RAY DIFFRACTION21chain 'F' and (resid 25 through 31 )F25 - 31
22X-RAY DIFFRACTION22chain 'F' and (resid 32 through 40 )F32 - 40
23X-RAY DIFFRACTION23chain 'F' and (resid 41 through 75 )F41 - 75
24X-RAY DIFFRACTION24chain 'F' and (resid 76 through 82 )F76 - 82
25X-RAY DIFFRACTION25chain 'F' and (resid 83 through 92 )F83 - 92
26X-RAY DIFFRACTION26chain 'F' and (resid 93 through 102 )F93 - 102
27X-RAY DIFFRACTION27chain 'G' and (resid 14 through 26 )G14 - 26
28X-RAY DIFFRACTION28chain 'G' and (resid 27 through 45 )G27 - 45
29X-RAY DIFFRACTION29chain 'G' and (resid 46 through 72 )G46 - 72
30X-RAY DIFFRACTION30chain 'G' and (resid 73 through 96 )G73 - 96
31X-RAY DIFFRACTION31chain 'G' and (resid 97 through 111 )G97 - 111
32X-RAY DIFFRACTION32chain 'G' and (resid 112 through 118 )G112 - 118
33X-RAY DIFFRACTION33chain 'H' and (resid 29 through 52 )H29 - 52
34X-RAY DIFFRACTION34chain 'H' and (resid 53 through 81 )H53 - 81
35X-RAY DIFFRACTION35chain 'H' and (resid 82 through 121 )H82 - 121
36X-RAY DIFFRACTION36chain 'I' and (resid -95 through -76 )I-95 - -76
37X-RAY DIFFRACTION37chain 'I' and (resid -75 through -56 )I-75 - -56
38X-RAY DIFFRACTION38chain 'I' and (resid -55 through -16 )I-55 - -16
39X-RAY DIFFRACTION39chain 'I' and (resid -15 through 4 )I-15 - 4
40X-RAY DIFFRACTION40chain 'I' and (resid 5 through 44 )I5 - 44
41X-RAY DIFFRACTION41chain 'I' and (resid 45 through 64 )I45 - 64
42X-RAY DIFFRACTION42chain 'I' and (resid 65 through 95 )I65 - 95
43X-RAY DIFFRACTION43chain 'J' and (resid -95 through -76 )J-95 - -76
44X-RAY DIFFRACTION44chain 'J' and (resid -75 through -56 )J-75 - -56
45X-RAY DIFFRACTION45chain 'J' and (resid -55 through -36 )J-55 - -36
46X-RAY DIFFRACTION46chain 'J' and (resid -35 through 24 )J-35 - 24
47X-RAY DIFFRACTION47chain 'J' and (resid 25 through 74 )J25 - 74
48X-RAY DIFFRACTION48chain 'J' and (resid 75 through 95 )J75 - 95
49X-RAY DIFFRACTION49chain 'a' and (resid 41 through 56 )a41 - 56
50X-RAY DIFFRACTION50chain 'a' and (resid 57 through 76 )a57 - 76
51X-RAY DIFFRACTION51chain 'a' and (resid 77 through 85 )a77 - 85
52X-RAY DIFFRACTION52chain 'a' and (resid 86 through 120 )a86 - 120
53X-RAY DIFFRACTION53chain 'a' and (resid 121 through 134 )a121 - 134
54X-RAY DIFFRACTION54chain 'b' and (resid 23 through 30 )b23 - 30
55X-RAY DIFFRACTION55chain 'b' and (resid 31 through 49 )b31 - 49
56X-RAY DIFFRACTION56chain 'b' and (resid 50 through 75 )b50 - 75
57X-RAY DIFFRACTION57chain 'b' and (resid 76 through 82 )b76 - 82
58X-RAY DIFFRACTION58chain 'b' and (resid 83 through 93 )b83 - 93
59X-RAY DIFFRACTION59chain 'b' and (resid 94 through 102 )b94 - 102
60X-RAY DIFFRACTION60chain 'c' and (resid 16 through 26 )c16 - 26
61X-RAY DIFFRACTION61chain 'c' and (resid 27 through 37 )c27 - 37
62X-RAY DIFFRACTION62chain 'c' and (resid 38 through 46 )c38 - 46
63X-RAY DIFFRACTION63chain 'c' and (resid 47 through 72 )c47 - 72
64X-RAY DIFFRACTION64chain 'c' and (resid 73 through 79 )c73 - 79
65X-RAY DIFFRACTION65chain 'c' and (resid 80 through 89 )c80 - 89
66X-RAY DIFFRACTION66chain 'c' and (resid 90 through 96 )c90 - 96
67X-RAY DIFFRACTION67chain 'c' and (resid 97 through 101 )c97 - 101
68X-RAY DIFFRACTION68chain 'c' and (resid 102 through 111 )c102 - 111
69X-RAY DIFFRACTION69chain 'c' and (resid 112 through 118 )c112 - 118
70X-RAY DIFFRACTION70chain 'd' and (resid 31 through 52 )d31 - 52
71X-RAY DIFFRACTION71chain 'd' and (resid 53 through 81 )d53 - 81
72X-RAY DIFFRACTION72chain 'd' and (resid 82 through 100 )d82 - 100
73X-RAY DIFFRACTION73chain 'd' and (resid 101 through 121 )d101 - 121
74X-RAY DIFFRACTION74chain 'e' and (resid 3 through 44 )e3 - 44
75X-RAY DIFFRACTION75chain 'e' and (resid 45 through 133 )e45 - 133
76X-RAY DIFFRACTION76chain 'f' and (resid 25 through 40 )f25 - 40
77X-RAY DIFFRACTION77chain 'f' and (resid 41 through 75 )f41 - 75
78X-RAY DIFFRACTION78chain 'f' and (resid 76 through 92 )f76 - 92
79X-RAY DIFFRACTION79chain 'f' and (resid 93 through 102 )f93 - 102
80X-RAY DIFFRACTION80chain 'g' and (resid 15 through 26 )g15 - 26
81X-RAY DIFFRACTION81chain 'g' and (resid 27 through 46 )g27 - 46
82X-RAY DIFFRACTION82chain 'g' and (resid 47 through 72 )g47 - 72
83X-RAY DIFFRACTION83chain 'g' and (resid 73 through 79 )g73 - 79
84X-RAY DIFFRACTION84chain 'g' and (resid 80 through 111 )g80 - 111
85X-RAY DIFFRACTION85chain 'g' and (resid 112 through 118 )g112 - 118
86X-RAY DIFFRACTION86chain 'h' and (resid 29 through 52 )h29 - 52
87X-RAY DIFFRACTION87chain 'h' and (resid 53 through 81 )h53 - 81
88X-RAY DIFFRACTION88chain 'h' and (resid 82 through 121 )h82 - 121
89X-RAY DIFFRACTION89chain 'M' and (resid 171 through 371 )M171 - 371
90X-RAY DIFFRACTION90chain 'M' and (resid 372 through 555 )M372 - 555
91X-RAY DIFFRACTION91chain 'M' and (resid 556 through 836 )M556 - 836
92X-RAY DIFFRACTION92chain 'N' and (resid 308 through 324 )N308 - 324
93X-RAY DIFFRACTION93chain 'N' and (resid 325 through 363 )N325 - 363
94X-RAY DIFFRACTION94chain 'N' and (resid 364 through 370 )N364 - 370
95X-RAY DIFFRACTION95chain 'N' and (resid 371 through 423 )N371 - 423
96X-RAY DIFFRACTION96chain 'N' and (resid 424 through 440 )N424 - 440
97X-RAY DIFFRACTION97chain 'm' and (resid 171 through 318 )m171 - 318
98X-RAY DIFFRACTION98chain 'm' and (resid 319 through 539 )m319 - 539
99X-RAY DIFFRACTION99chain 'm' and (resid 540 through 836 )m540 - 836
100X-RAY DIFFRACTION100chain 'n' and (resid 308 through 363 )n308 - 363
101X-RAY DIFFRACTION101chain 'n' and (resid 364 through 440 )n364 - 440
102X-RAY DIFFRACTION102chain 'K' and (resid 171 through 318 )K171 - 318
103X-RAY DIFFRACTION103chain 'K' and (resid 319 through 407 )K319 - 407
104X-RAY DIFFRACTION104chain 'K' and (resid 408 through 510 )K408 - 510
105X-RAY DIFFRACTION105chain 'K' and (resid 511 through 578 )K511 - 578
106X-RAY DIFFRACTION106chain 'K' and (resid 579 through 777 )K579 - 777
107X-RAY DIFFRACTION107chain 'K' and (resid 778 through 836 )K778 - 836
108X-RAY DIFFRACTION108chain 'L' and (resid 308 through 317 )L308 - 317
109X-RAY DIFFRACTION109chain 'L' and (resid 318 through 324 )L318 - 324
110X-RAY DIFFRACTION110chain 'L' and (resid 325 through 329 )L325 - 329
111X-RAY DIFFRACTION111chain 'L' and (resid 330 through 362 )L330 - 362
112X-RAY DIFFRACTION112chain 'L' and (resid 363 through 370 )L363 - 370
113X-RAY DIFFRACTION113chain 'L' and (resid 371 through 384 )L371 - 384
114X-RAY DIFFRACTION114chain 'L' and (resid 385 through 398 )L385 - 398
115X-RAY DIFFRACTION115chain 'L' and (resid 399 through 423 )L399 - 423
116X-RAY DIFFRACTION116chain 'L' and (resid 424 through 429 )L424 - 429
117X-RAY DIFFRACTION117chain 'L' and (resid 430 through 440 )L430 - 440
118X-RAY DIFFRACTION118chain 'k' and (resid 171 through 287 )k171 - 287
119X-RAY DIFFRACTION119chain 'k' and (resid 288 through 409 )k288 - 409
120X-RAY DIFFRACTION120chain 'k' and (resid 410 through 513 )k410 - 513
121X-RAY DIFFRACTION121chain 'k' and (resid 514 through 546 )k514 - 546
122X-RAY DIFFRACTION122chain 'k' and (resid 547 through 777 )k547 - 777
123X-RAY DIFFRACTION123chain 'k' and (resid 778 through 836 )k778 - 836
124X-RAY DIFFRACTION124chain 'l' and (resid 308 through 317 )l308 - 317
125X-RAY DIFFRACTION125chain 'l' and (resid 318 through 372 )l318 - 372
126X-RAY DIFFRACTION126chain 'l' and (resid 373 through 440 )l373 - 440
127X-RAY DIFFRACTION127chain 'i' and (resid -95 through -76 )i-95 - -76
128X-RAY DIFFRACTION128chain 'i' and (resid -75 through -56 )i-75 - -56
129X-RAY DIFFRACTION129chain 'i' and (resid -55 through -16 )i-55 - -16
130X-RAY DIFFRACTION130chain 'i' and (resid -15 through 4 )i-15 - 4
131X-RAY DIFFRACTION131chain 'i' and (resid 5 through 34 )i5 - 34
132X-RAY DIFFRACTION132chain 'i' and (resid 35 through 64 )i35 - 64
133X-RAY DIFFRACTION133chain 'i' and (resid 65 through 95 )i65 - 95
134X-RAY DIFFRACTION134chain 'j' and (resid -95 through -76 )j-95 - -76
135X-RAY DIFFRACTION135chain 'j' and (resid -75 through -56 )j-75 - -56
136X-RAY DIFFRACTION136chain 'j' and (resid -55 through 4 )j-55 - 4
137X-RAY DIFFRACTION137chain 'j' and (resid 5 through 74 )j5 - 74
138X-RAY DIFFRACTION138chain 'j' and (resid 75 through 84 )j75 - 84
139X-RAY DIFFRACTION139chain 'j' and (resid 85 through 95 )j85 - 95

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