登録情報 | データベース: PDB / ID: 6vg3 |
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タイトル | Structure of unliganded, inactive PTK7 kinase domain |
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要素 | Inactive tyrosine-protein kinase 7 |
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キーワード | TRANSFERASE / Kinase / Pseudokinase / Autoinhibition |
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機能・相同性 | 機能・相同性情報
axis elongation / : / convergent extension / : / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / establishment of planar polarity / coronary vasculature development / lung-associated mesenchyme development / establishment of epithelial cell apical/basal polarity ...axis elongation / : / convergent extension / : / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / establishment of planar polarity / coronary vasculature development / lung-associated mesenchyme development / establishment of epithelial cell apical/basal polarity / ventricular septum development / plasma membrane => GO:0005886 / cellular response to retinoic acid / kidney development / wound healing / positive regulation of neuron projection development / cell-cell junction / cell migration / positive regulation of canonical Wnt signaling pathway / cell adhesion / protein kinase activity / focal adhesion / signal transduction / ATP binding類似検索 - 分子機能 Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain ...Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | Malhotra, K. / Stayrook, S.E. / Sheetz, J. / Lemmon, M.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM122485 | 米国 |
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引用 | ジャーナル: Mol.Cell / 年: 2020 タイトル: Structural insights into receptor tyrosine kinase pseudokinase function 著者: Sheetz, J.B. / Mathea, S. / Karvonen, H. / Malhotra, K. / Chaterjee, D. / Perttila, R. / Niininen, W. / Stayrook, S.E. / Radhakrishnan, R. / Ungureanu, D. / Knapp, S. / Lemmon, M.A. |
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履歴 | 登録 | 2020年1月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年5月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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