Entry | Database: PDB / ID: 6uqd |
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Title | Co-complex of S. pyogenes 10782 streptopain bound with a SuFEx-based optimized small molecule inhibitor |
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Components | Streptopain |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / speb / streptopain / inhibitor / nitrile / HYDROLASE-HYDROLASE INHIBITOR complex |
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Function / homology | Function and homology information
streptopain / symbiont-mediated suppression of host autophagy / symbiont-induced defense-related programmed cell death / evasion of host immune response / host cell cytosol / cysteine-type peptidase activity / toxin activity / host extracellular space / cysteine-type endopeptidase activity / proteolysis / extracellular regionSimilarity search - Function Peptidase C10, streptopain superfmaily / Spi protease inhibitor / Spi protease inhibitor / Peptidase C10, streptopain / Peptidase C10 family / Papain-like cysteine peptidase superfamilySimilarity search - Domain/homology |
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Biological species | Streptococcus pyogenes (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.02 Å |
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Authors | Wolan, D.W. / Woehl, J.L. / Kitamura, S. |
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Citation | Journal: J.Am.Chem.Soc. / Year: 2020 Title: Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry. Authors: Kitamura, S. / Zheng, Q. / Woehl, J.L. / Solania, A. / Chen, E. / Dillon, N. / Hull, M.V. / Kotaniguchi, M. / Cappiello, J.R. / Kitamura, S. / Nizet, V. / Sharpless, K.B. / Wolan, D.W. |
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History | Deposition | Oct 18, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 26, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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