登録情報 | データベース: PDB / ID: 6ttk |
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タイトル | Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide |
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要素 | - DVL1
- Kelch-like protein 12
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キーワード | LIGASE / Cullin3 E3 ligase / Kelch / Complex / Substrate peptide |
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機能・相同性 | 機能・相同性情報
positive regulation of protein localization to presynapse / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / skeletal muscle acetylcholine-gated channel clustering / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / neural crest formation / protein localization to microtubule / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization ...positive regulation of protein localization to presynapse / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / skeletal muscle acetylcholine-gated channel clustering / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / neural crest formation / protein localization to microtubule / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / presynapse assembly / neural crest cell development / collateral sprouting / COPII vesicle coat / COPII vesicle coating / WNT5:FZD7-mediated leishmania damping / neurotransmitter secretion / dendritic spine morphogenesis / frizzled binding / axon extension / PCP/CE pathway / Wnt signalosome / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / dendrite morphogenesis / neural tube development / Wnt signaling pathway, planar cell polarity pathway / clathrin-coated vesicle / regulation of postsynapse organization / neuromuscular junction development / regulation of synaptic vesicle exocytosis / Cul3-RING ubiquitin ligase complex / heart looping / COPII-coated ER to Golgi transport vesicle / outflow tract morphogenesis / neuronal dense core vesicle / receptor clustering / synaptic vesicle exocytosis / protein monoubiquitination / positive regulation of excitatory postsynaptic potential / social behavior / protein localization to nucleus / centriolar satellite / lateral plasma membrane / canonical Wnt signaling pathway / prepulse inhibition / endoplasmic reticulum to Golgi vesicle-mediated transport / cytoplasmic microtubule organization / negative regulation of protein phosphorylation / TCF dependent signaling in response to WNT / Degradation of DVL / RHO GTPases Activate Formins / synapse organization / axon guidance / Schaffer collateral - CA1 synapse / beta-catenin binding / Wnt signaling pathway / small GTPase binding / positive regulation of neuron projection development / regulation of protein localization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / presynapse / growth cone / cytoplasmic vesicle / microtubule / dendritic spine / postsynaptic density / protein stabilization / intracellular signal transduction / neuron projection / positive regulation of protein phosphorylation / intracellular membrane-bounded organelle / neuronal cell body / glutamatergic synapse / synapse / regulation of DNA-templated transcription / protein kinase binding / enzyme binding / positive regulation of transcription by RNA polymerase II / identical protein binding / cytosol類似検索 - 分子機能 Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. ...Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / Kelch-type beta propeller / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / 6 Propeller / Neuraminidase / SKP1/BTB/POZ domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Mainly Beta類似検索 - ドメイン・相同性 Segment polarity protein dishevelled homolog DVL-1 / Kelch-like protein 12類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.383 Å |
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データ登録者 | Chen, Z. / Williams, E. / Pike, A.C.W. / Strain-Damerell, C. / Wang, D. / Chalk, R. / Burgess-Brown, N. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. ...Chen, Z. / Williams, E. / Pike, A.C.W. / Strain-Damerell, C. / Wang, D. / Chalk, R. / Burgess-Brown, N. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A.N. |
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引用 | ジャーナル: Open Biology / 年: 2020 タイトル: Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. 著者: Chen, Z. / Wasney, G.A. / Picaud, S. / Filippakopoulos, P. / Vedadi, M. / D'Angiolella, V. / Bullock, A.N. |
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履歴 | 登録 | 2019年12月27日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年2月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年8月26日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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