Entry | Database: PDB / ID: 6tpm |
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Title | Crystal structure of AmpC from E.coli with Relebactam (MK-7655) |
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Components | Beta-lactamase |
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Keywords | HYDROLASE / beta lactamase / antibiotic resistance / diazabicyclooctane / DBO |
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Function / homology | Function and homology information
antibiotic catabolic process / beta-lactamase activity / beta-lactamase / outer membrane-bounded periplasmic space / response to antibioticSimilarity search - Function Beta-lactamase, class-C active site / Beta-lactamase class-C active site. / Beta-lactamase-related / Beta-lactamase / Beta-lactamase/transpeptidase-likeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 1.72 Å |
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Authors | Lang, P.A. / Leissing, T.M. / Schofield, C.J. / Brem, J. |
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Funding support | United Kingdom, 1items Organization | Grant number | Country |
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Medical Research Council (MRC, United Kingdom) | MRF-145-0004-TPG-AVISO | United Kingdom |
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Citation | Journal: Antimicrob.Agents Chemother. / Year: 2021 Title: Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Authors: Lang, P.A. / Leissing, T.M. / Page, M.G.P. / Schofield, C.J. / Brem, J. |
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History | Deposition | Dec 13, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Nov 25, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 2, 2020 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Feb 3, 2021 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.year / _citation_author.identifier_ORCID |
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Revision 1.3 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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