Entry | Database: PDB / ID: 6td2 |
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Title | Mus musculus Acetylcholinesterase in complex with N-(2-(diethylamino)ethyl)-1-(4-(trifluoromethyl)phenyl)methanesulfonamide |
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Components | Acetylcholinesterase |
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Keywords | HYDROLASE / Complex / Inhibitor |
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Function / homology | Function and homology information
acetylcholine metabolic process / serine hydrolase activity / choline binding / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / acetylcholine receptor signaling pathway / positive regulation of dendrite morphogenesis / osteoblast development / acetylcholinesterase activity ...acetylcholine metabolic process / serine hydrolase activity / choline binding / acetylcholine catabolic process / acetylcholine binding / acetylcholinesterase / acetylcholine receptor signaling pathway / positive regulation of dendrite morphogenesis / osteoblast development / acetylcholinesterase activity / choline metabolic process / positive regulation of axonogenesis / basement membrane / regulation of receptor recycling / side of membrane / synaptic cleft / laminin binding / synapse assembly / collagen binding / response to insulin / neuromuscular junction / receptor internalization / : / retina development in camera-type eye / nuclear envelope / presynaptic membrane / positive regulation of cold-induced thermogenesis / postsynaptic membrane / cell adhesion / endoplasmic reticulum lumen / axon / neuronal cell body / synapse / dendrite / perinuclear region of cytoplasm / Golgi apparatus / cell surface / protein homodimerization activity / extracellular space / identical protein binding / plasma membraneSimilarity search - Function Acetylcholinesterase, tetramerisation domain / Acetylcholinesterase tetramerisation domain / Cholinesterase / Carboxylesterase type B, conserved site / Carboxylesterases type-B signature 2. / Carboxylesterase type B, active site / Carboxylesterases type-B serine active site. / Carboxylesterase, type B / Carboxylesterase family / Alpha/Beta hydrolase foldSimilarity search - Domain/homology |
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Biological species | ![](img/tx_mammal.gif) Mus musculus (house mouse) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 2.8 Å |
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Authors | Forsgren, N. / Ekstrom, F. |
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Funding support | 2items Organization | Grant number | Country |
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Other government | | | Swedish Research Council | | |
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Citation | Journal: J.Phys.Chem.B / Year: 2020 Title: Physical Mechanisms Governing Substituent Effects on Arene-Arene Interactions in a Protein Milieu. Authors: Andersson, C.D. / Mishra, B.K. / Forsgren, N. / Ekstrom, F. / Linusson, A. |
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History | Deposition | Nov 7, 2019 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Oct 14, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 21, 2020 | Group: Derived calculations / Category: pdbx_struct_assembly / pdbx_struct_assembly_gen |
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Revision 1.2 | Jan 24, 2024 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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