登録情報 | データベース: PDB / ID: 6tce |
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タイトル | Crystal structure of the GGCT site-bound MH1 domain of Smad5 containing a GGGS insertion in the Loop1 |
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要素 | - DNA (5'-D(P*TP*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3')
- Mothers against decapentaplegic homolog 5
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キーワード | TRANSCRIPTION / TGF-B |
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機能・相同性 | 機能・相同性情報
negative regulation of Fas signaling pathway / Mullerian duct regression / osteoblast fate commitment / SMAD protein complex / heteromeric SMAD protein complex / DEAD/H-box RNA helicase binding / cardiac conduction system development / Signaling by BMP / embryonic pattern specification / SMAD protein signal transduction ...negative regulation of Fas signaling pathway / Mullerian duct regression / osteoblast fate commitment / SMAD protein complex / heteromeric SMAD protein complex / DEAD/H-box RNA helicase binding / cardiac conduction system development / Signaling by BMP / embryonic pattern specification / SMAD protein signal transduction / I-SMAD binding / cartilage development / ureteric bud development / germ cell development / cellular response to organic cyclic compound / anatomical structure morphogenesis / BMP signaling pathway / positive regulation of osteoblast differentiation / cardiac muscle contraction / transforming growth factor beta receptor signaling pathway / erythrocyte differentiation / bone development / DNA-binding transcription repressor activity, RNA polymerase II-specific / osteoblast differentiation / sequence-specific double-stranded DNA binding / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / ubiquitin protein ligase binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / mitochondrion / nucleoplasm / nucleus / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins ...Smad3; Chain A / SMAD MH1 domain / MAD homology, MH1 / Dwarfin / SMAD MH1 domain superfamily / MAD homology domain 1 (MH1) profile. / SMAD domain, Dwarfin-type / MH2 domain / MAD homology domain 2 (MH2) profile. / Domain B in dwarfin family proteins / MAD homology 1, Dwarfin-type / MH1 domain / Domain A in dwarfin family proteins / SMAD-like domain superfamily / SMAD/FHA domain superfamily / Alpha-Beta Complex / Alpha Beta類似検索 - ドメイン・相同性 DNA / DNA (> 10) / Mothers against decapentaplegic homolog 5類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.92 Å |
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データ登録者 | Pluta, R. / Macias, M.J. |
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資金援助 | スペイン, 2件 組織 | 認可番号 | 国 |
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Spanish Ministry of Economy and Competitiveness | | スペイン | European Commission | | |
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引用 | ジャーナル: Comput Struct Biotechnol J / 年: 2021 タイトル: Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes. 著者: Ruiz, L. / Kaczmarska, Z. / Gomes, T. / Aragon, E. / Torner, C. / Freier, R. / Baginski, B. / Martin-Malpartida, P. / de Martin Garrido, N. / Marquez, J.A. / Cordeiro, T.N. / Pluta, R. / Macias, M.J. |
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履歴 | 登録 | 2019年11月5日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年11月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年4月29日 | Group: Structure summary / カテゴリ: audit_author / Item: _audit_author.name |
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改定 1.2 | 2021年2月10日 | Group: Database references / Refinement description / カテゴリ: citation / citation_author / software Item: _citation.journal_abbrev / _citation.journal_id_CSD ..._citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name / _software.name |
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改定 1.3 | 2024年1月24日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _citation.country / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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