Entry Database : PDB / ID : 6tc2 Structure visualization Downloads & linksTitle Monoclinic human insulin in complex with p-coumaric acid ComponentsInsulin Details Keywords HORMONE / HUMAN INSULIN / p-coumaric acid / HEXAMER / COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / positive regulation of nitric oxide mediated signal transduction / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / IRS activation / Insulin processing / regulation of protein secretion / positive regulation of peptide hormone secretion ... negative regulation of NAD(P)H oxidase activity / negative regulation of glycogen catabolic process / positive regulation of nitric oxide mediated signal transduction / negative regulation of fatty acid metabolic process / negative regulation of feeding behavior / Signaling by Insulin receptor / IRS activation / Insulin processing / regulation of protein secretion / positive regulation of peptide hormone secretion / positive regulation of respiratory burst / negative regulation of acute inflammatory response / Regulation of gene expression in beta cells / alpha-beta T cell activation / regulation of cellular amino acid metabolic process / negative regulation of respiratory burst involved in inflammatory response / positive regulation of dendritic spine maintenance / positive regulation of glycogen biosynthetic process / Synthesis, secretion, and deacylation of Ghrelin / negative regulation of protein secretion / regulation of protein localization to plasma membrane / fatty acid homeostasis / Signal attenuation / negative regulation of lipid catabolic process / negative regulation of gluconeogenesis / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / COPI-mediated anterograde transport / positive regulation of lipid biosynthetic process / negative regulation of reactive oxygen species biosynthetic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / positive regulation of insulin receptor signaling pathway / nitric oxide-cGMP-mediated signaling / transport vesicle / positive regulation of protein autophosphorylation / Insulin receptor recycling / insulin-like growth factor receptor binding / neuron projection maintenance / NPAS4 regulates expression of target genes / positive regulation of protein metabolic process / positive regulation of brown fat cell differentiation / activation of protein kinase B activity / endoplasmic reticulum-Golgi intermediate compartment membrane / positive regulation of glycolytic process / positive regulation of mitotic nuclear division / Insulin receptor signalling cascade / positive regulation of nitric-oxide synthase activity / positive regulation of cytokine production / positive regulation of long-term synaptic potentiation / acute-phase response / Regulation of insulin secretion / negative regulation of protein catabolic process / endosome lumen / positive regulation of glucose import / positive regulation of protein secretion / negative regulation of proteolysis / positive regulation of cell differentiation / regulation of transmembrane transporter activity / insulin receptor binding / wound healing / regulation of synaptic plasticity / vasodilation / hormone activity / cognition / positive regulation of neuron projection development / positive regulation of protein localization to nucleus / Golgi lumen / glucose metabolic process / regulation of protein localization / glucose homeostasis / insulin receptor signaling pathway / cell-cell signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of NF-kappaB transcription factor activity / positive regulation of cell growth / protease binding / secretory granule lumen / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of cell migration / G protein-coupled receptor signaling pathway / Amyloid fiber formation / Golgi membrane / endoplasmic reticulum lumen / negative regulation of gene expression / positive regulation of cell population proliferation / positive regulation of gene expression / regulation of DNA-templated transcription / extracellular space / extracellular region / identical protein binding Similarity search - Function Insulin / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.36 Å DetailsAuthors Triandafillidis, D.-P. / Parthenios, N. / Spiliopoulou, M. / Valmas, A. / Kosinas, C. / Gozzo, F. / Reinle-Schmitt, M. / Beckers, D. / Degen, T. / Pop, M. ...Triandafillidis, D.-P. / Parthenios, N. / Spiliopoulou, M. / Valmas, A. / Kosinas, C. / Gozzo, F. / Reinle-Schmitt, M. / Beckers, D. / Degen, T. / Pop, M. / Fitch, A. / Wollenhaupt, J. / Weiss, M.S. / Karavassili, F. / Margiolaki, I. Funding support Greece, 2items Details Hide detailsOrganization Grant number Country General Secretariat for Research and Technology Greece Hellenic Foundation for Research and Innovation 3051 Greece
CitationJournal : Acta Crystallogr D Struct Biol / Year : 2020Title : Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.Authors: Triandafillidis, D.P. / Parthenios, N. / Spiliopoulou, M. / Valmas, A. / Kosinas, C. / Gozzo, F. / Reinle-Schmitt, M. / Beckers, D. / Degen, T. / Pop, M. / Fitch, A.N. / Wollenhaupt, J. / ... Authors : Triandafillidis, D.P. / Parthenios, N. / Spiliopoulou, M. / Valmas, A. / Kosinas, C. / Gozzo, F. / Reinle-Schmitt, M. / Beckers, D. / Degen, T. / Pop, M. / Fitch, A.N. / Wollenhaupt, J. / Weiss, M.S. / Karavassili, F. / Margiolaki, I. History Deposition Nov 4, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 11, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 18, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name Revision 1.2 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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