登録情報 | データベース: PDB / ID: 6syg |
---|
タイトル | Crystal structure of the Cyclic Nucleotide-Binding Homology Domain of the human KCNH2 channel |
---|
要素 | Potassium voltage-gated channel subfamily H member 2 |
---|
キーワード | TRANSPORT PROTEIN / Intracellular domain / CNBHD / hERG |
---|
機能・相同性 | 機能・相同性情報
Phase 3 - rapid repolarisation / inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / cellular response to xenobiotic stimulus => GO:0071466 / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / Voltage gated Potassium channels / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / negative regulation of potassium ion transmembrane transport ...Phase 3 - rapid repolarisation / inward rectifier potassium channel complex / negative regulation of potassium ion export across plasma membrane / cellular response to xenobiotic stimulus => GO:0071466 / regulation of heart rate by hormone / Phase 3 - rapid repolarisation / Voltage gated Potassium channels / voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization / membrane repolarization during action potential / negative regulation of potassium ion transmembrane transport / membrane repolarization during ventricular cardiac muscle cell action potential / membrane repolarization during cardiac muscle cell action potential / potassium ion export across plasma membrane / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / C3HC4-type RING finger domain binding / regulation of membrane repolarization / membrane repolarization / positive regulation of potassium ion transmembrane transport / Voltage gated Potassium channels / inward rectifier potassium channel activity / potassium ion homeostasis / membrane depolarization during action potential / ventricular cardiac muscle cell action potential / regulation of potassium ion transmembrane transport / delayed rectifier potassium channel activity / regulation of ventricular cardiac muscle cell membrane repolarization / spinal cord development / plasma membrane => GO:0005886 / regulation of heart rate by cardiac conduction / voltage-gated potassium channel activity / potassium ion import across plasma membrane / potassium channel activity / cardiac muscle contraction / voltage-gated potassium channel complex / potassium ion transmembrane transport / regulation of membrane potential / potassium ion transport / brain development / cellular response to xenobiotic stimulus / nuclear envelope / monoatomic ion channel activity / scaffold protein binding / transcription cis-regulatory region binding / ubiquitin protein ligase binding / protein-containing complex binding / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription / cell surface / protein homodimerization activity / identical protein binding / plasma membrane / cytoplasm類似検索 - 分子機能 Potassium channel, voltage-dependent, ERG / : / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS domain / PAS-associated, C-terminal / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain ...Potassium channel, voltage-dependent, ERG / : / Potassium channel, voltage-dependent, EAG/ELK/ERG / PAS domain / PAS-associated, C-terminal / PAC domain profile. / PAC motif / Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / Jelly Rolls / Voltage-dependent channel domain superfamily / PAS repeat profile. / PAS domain / RmlC-like jelly roll fold / PAS domain superfamily / Ion transport domain / Ion transport protein / Jelly Rolls / Sandwich / Mainly Beta類似検索 - ドメイン・相同性 Potassium voltage-gated channel subfamily H member 2 / Potassium voltage-gated channel subfamily H member 2類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.5 Å |
---|
データ登録者 | Ben-Bassat, A. / Giladi, M. / Haitin, Y. |
---|
資金援助 | イスラエル, 4件 組織 | 認可番号 | 国 |
---|
Israel Science Foundation | 1721/16 | イスラエル | Israel Science Foundation | 1775/12 | イスラエル | Other private | ICRF 01214 | イスラエル | German-Israeli Foundation for Research and Development | I-2425-418.13/2016 | イスラエル |
|
---|
引用 | ジャーナル: J.Gen.Physiol. / 年: 2020 タイトル: Structure of KCNH2 cyclic nucleotide-binding homology domain reveals a functionally vital salt-bridge. 著者: Ben-Bassat, A. / Giladi, M. / Haitin, Y. |
---|
履歴 | 登録 | 2019年9月27日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2020年3月4日 | Provider: repository / タイプ: Initial release |
---|
改定 2.0 | 2020年3月18日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Source and taxonomy / Structure summary カテゴリ: atom_site / entity_name_com ...atom_site / entity_name_com / entity_src_gen / pdbx_nonpoly_scheme / struct_ref / struct_ref_seq / struct_ref_seq_dif Item: _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ..._atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _entity_src_gen.gene_src_common_name / _entity_src_gen.pdbx_gene_src_gene / _entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id / _entity_src_gen.pdbx_gene_src_scientific_name / _pdbx_nonpoly_scheme.auth_seq_num / _struct_ref.db_code / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_db_accession / _struct_ref_seq.db_align_beg / _struct_ref_seq.db_align_end / _struct_ref_seq.pdbx_db_accession / _struct_ref_seq_dif.pdbx_seq_db_accession_code |
---|
改定 2.1 | 2020年4月15日 | Group: Database references / カテゴリ: citation Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
---|
改定 3.0 | 2020年4月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Refinement description / Structure summary カテゴリ: atom_site / atom_site_anisotrop ...atom_site / atom_site_anisotrop / entity / pdbx_distant_solvent_atoms / pdbx_nonpoly_scheme / pdbx_refine_tls / pdbx_struct_assembly_prop / pdbx_struct_special_symmetry / pdbx_validate_close_contact / pdbx_validate_symm_contact / refine / refine_hist / refine_ls_restr / refine_ls_shell / software Item: _entity.pdbx_number_of_molecules / _pdbx_distant_solvent_atoms.auth_seq_id ..._entity.pdbx_number_of_molecules / _pdbx_distant_solvent_atoms.auth_seq_id / _pdbx_distant_solvent_atoms.neighbor_macromolecule_distance / _pdbx_refine_tls.L[1][1] / _pdbx_refine_tls.L[1][2] / _pdbx_refine_tls.L[1][3] / _pdbx_refine_tls.L[2][2] / _pdbx_refine_tls.L[2][3] / _pdbx_refine_tls.L[3][3] / _pdbx_refine_tls.S[1][1] / _pdbx_refine_tls.S[1][2] / _pdbx_refine_tls.S[1][3] / _pdbx_refine_tls.S[2][1] / _pdbx_refine_tls.S[2][2] / _pdbx_refine_tls.S[2][3] / _pdbx_refine_tls.S[3][1] / _pdbx_refine_tls.S[3][2] / _pdbx_refine_tls.S[3][3] / _pdbx_refine_tls.T[1][1] / _pdbx_refine_tls.T[1][2] / _pdbx_refine_tls.T[1][3] / _pdbx_refine_tls.T[2][2] / _pdbx_refine_tls.T[2][3] / _pdbx_refine_tls.T[3][3] / _pdbx_refine_tls.origin_x / _pdbx_refine_tls.origin_y / _pdbx_refine_tls.origin_z / _pdbx_struct_assembly_prop.value / _refine.B_iso_mean / _refine.ls_R_factor_R_free / _refine.ls_R_factor_R_work / _refine.ls_R_factor_obs / _refine.ls_number_reflns_R_work / _refine.overall_SU_ML / _refine.pdbx_overall_phase_error / _refine.solvent_model_details / _refine_hist.number_atoms_solvent / _refine_hist.number_atoms_total / _refine_hist.pdbx_number_atoms_protein / _refine_ls_restr.dev_ideal / _refine_ls_restr.number 解説: Model completeness / 詳細: OXT added to the C-terminal residue. / Provider: author / タイプ: Coordinate replacement |
---|
改定 3.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|