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Yorodumi- PDB-6smc: mouse Interleukin-12 subunit beta - p80 homodimer in space group P1 -
+Open data
-Basic information
Entry | Database: PDB / ID: 6smc | ||||||||||||
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Title | mouse Interleukin-12 subunit beta - p80 homodimer in space group P1 | ||||||||||||
Components | Interleukin-12 subunit beta | ||||||||||||
Keywords | CYTOKINE / homodimer / antagonist / fibronectin / secreted glycoprotein | ||||||||||||
Function / homology | Function and homology information Interleukin-12 signaling / Interleukin-23 signaling / interleukin-23 receptor binding / interleukin-12 alpha subunit binding / interleukin-12 complex / interleukin-23 complex / natural killer cell activation involved in immune response / positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / negative regulation of vascular endothelial growth factor signaling pathway / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ...Interleukin-12 signaling / Interleukin-23 signaling / interleukin-23 receptor binding / interleukin-12 alpha subunit binding / interleukin-12 complex / interleukin-23 complex / natural killer cell activation involved in immune response / positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / negative regulation of vascular endothelial growth factor signaling pathway / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of T-helper 1 type immune response / positive regulation of smooth muscle cell apoptotic process / natural killer cell activation / T-helper cell differentiation / negative regulation of interleukin-17 production / positive regulation of osteoclast differentiation / positive regulation of NK T cell proliferation / interleukin-12-mediated signaling pathway / response to UV-B / cytokine receptor activity / positive regulation of natural killer cell proliferation / positive regulation of granulocyte macrophage colony-stimulating factor production / negative regulation of interleukin-10 production / positive regulation of activated T cell proliferation / defense response to protozoan / positive regulation of interleukin-17 production / positive regulation of interleukin-10 production / : / immunoglobulin mediated immune response / negative regulation of protein secretion / T cell proliferation / positive regulation of T cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of defense response to virus by host / negative regulation of inflammatory response to antigenic stimulus / positive regulation of interleukin-12 production / negative regulation of smooth muscle cell proliferation / cytokine activity / endosome lumen / growth factor activity / cellular response to type II interferon / cytokine-mediated signaling pathway / Golgi lumen / positive regulation of T cell mediated cytotoxicity / positive regulation of type II interferon production / positive regulation of tumor necrosis factor production / cell migration / cellular response to lipopolysaccharide / defense response to virus / defense response to Gram-negative bacterium / cell population proliferation / cell surface receptor signaling pathway / protein heterodimerization activity / endoplasmic reticulum lumen / external side of plasma membrane / protein-containing complex binding / cell surface / extracellular space / extracellular region / identical protein binding / cytoplasm Similarity search - Function | ||||||||||||
Biological species | Mus musculus (house mouse) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.5 Å | ||||||||||||
Authors | Bloch, Y. / Savvides, S.N. | ||||||||||||
Funding support | Belgium, 3items
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Citation | Journal: To Be Published Title: Around she goes: the structure of mouse Interleukin-12 p80 Authors: Bloch, Y. / Savvides, S.N. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6smc.cif.gz | 813.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6smc.ent.gz | 612.2 KB | Display | PDB format |
PDBx/mmJSON format | 6smc.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6smc_validation.pdf.gz | 1.5 MB | Display | wwPDB validaton report |
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Full document | 6smc_full_validation.pdf.gz | 1.5 MB | Display | |
Data in XML | 6smc_validation.xml.gz | 42.5 KB | Display | |
Data in CIF | 6smc_validation.cif.gz | 57.7 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/sm/6smc ftp://data.pdbj.org/pub/pdb/validation_reports/sm/6smc | HTTPS FTP |
-Related structure data
Related structure data | 6sp3C 7purC 7r3nC 6sffS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
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-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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