登録情報 データベース : PDB / ID : 6sf3 構造の表示 ダウンロードとリンクタイトル Bone morphogenetic protein 10 (BMP10) in complex with extracellular domain of activin receptor-like kinase 1 (ALK1) at 2.3 Angstrom 要素Bone morphogenetic protein 10 Serine/threonine-protein kinase receptor R3 詳細キーワード CYTOKINE / BMP10 / ALK1 / complex / signalling / TGFbeta / BMP機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
atrial cardiac muscle tissue morphogenesis / regulation of cardiac muscle hypertrophy in response to stress / lymphatic endothelial cell differentiation / regulation of endothelial cell proliferation / positive regulation of sarcomere organization / positive regulation of cell proliferation involved in heart morphogenesis / negative regulation of endothelial cell differentiation / dorsal aorta morphogenesis / positive regulation of epithelial cell differentiation / blood vessel maturation ... atrial cardiac muscle tissue morphogenesis / regulation of cardiac muscle hypertrophy in response to stress / lymphatic endothelial cell differentiation / regulation of endothelial cell proliferation / positive regulation of sarcomere organization / positive regulation of cell proliferation involved in heart morphogenesis / negative regulation of endothelial cell differentiation / dorsal aorta morphogenesis / positive regulation of epithelial cell differentiation / blood vessel maturation / venous blood vessel development / ventricular cardiac muscle cell development / positive regulation of cartilage development / transforming growth factor beta receptor activity / telethonin binding / lymphangiogenesis / positive regulation of chondrocyte differentiation / negative regulation of cardiac muscle hypertrophy / BMP receptor complex / retina vasculature development in camera-type eye / BMP receptor activity / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of endothelial cell differentiation / activin receptor activity, type I / transforming growth factor beta receptor activity, type I / negative regulation of focal adhesion assembly / endothelial tube morphogenesis / positive regulation of bicellular tight junction assembly / regulation of blood vessel endothelial cell migration / artery development / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / Signaling by BMP / activin binding / cellular response to BMP stimulus / activin receptor signaling pathway / heart trabecula formation / receptor serine/threonine kinase binding / positive regulation of BMP signaling pathway / adult heart development / negative regulation of cell adhesion / transforming growth factor beta binding / dorsal/ventral pattern formation / blood circulation / wound healing, spreading of epidermal cells / Molecules associated with elastic fibres / negative regulation of endothelial cell migration / ventricular cardiac muscle tissue morphogenesis / cardiac muscle cell proliferation / endocardial cushion morphogenesis / sarcomere organization / positive regulation of Notch signaling pathway / positive regulation of cardiac muscle hypertrophy / regulation of DNA replication / SMAD binding / negative regulation of endothelial cell proliferation / positive regulation of SMAD protein signal transduction / negative regulation of blood vessel endothelial cell migration / regulation of cardiac muscle contraction / blood vessel remodeling / BMP signaling pathway / positive regulation of cardiac muscle cell proliferation / cellular response to transforming growth factor beta stimulus / positive regulation of endothelial cell proliferation / negative regulation of cell migration / transforming growth factor beta receptor signaling pathway / kidney development / cytokine activity / growth factor activity / hormone activity / negative regulation of cell growth / cellular response to growth factor stimulus / regulation of blood pressure / Z disc / positive regulation of angiogenesis / heart development / angiogenesis / in utero embryonic development / cell adhesion / response to hypoxia / negative regulation of cell population proliferation / phosphorylation / negative regulation of gene expression / protein serine/threonine kinase activity / neuronal cell body / dendrite / positive regulation of gene expression / regulation of DNA-templated transcription / protein kinase binding / positive regulation of DNA-templated transcription / cell surface / signal transduction / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / ATP binding / metal ion binding / plasma membrane / cytoplasm 類似検索 - 分子機能 TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family ... TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / CD59 / CD59 / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / Cystine-knot cytokine / Ribbon / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 Bone morphogenetic protein 10 / Serine/threonine-protein kinase receptor R3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.3000067422 Å 詳細データ登録者 Guo, J. / Yu, M. / Li, W. 資金援助 英国, 3件 詳細 詳細を隠す組織 認可番号 国 British Heart Foundation PG/12/54/29734 英国 British Heart Foundation PG/15/39/31519 英国 British Heart Foundation PG/17/1/32532 英国
引用ジャーナル : Nat Commun / 年 : 2020タイトル : Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms.著者 : Salmon, R.M. / Guo, J. / Wood, J.H. / Tong, Z. / Beech, J.S. / Lawera, A. / Yu, M. / Grainger, D.J. / Reckless, J. / Morrell, N.W. / Li, W. 履歴 登録 2019年7月31日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年4月8日 Provider : repository / タイプ : Initial release改定 1.1 2020年4月15日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID 改定 1.2 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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