登録情報 | データベース: PDB / ID: 6s64 |
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タイトル | Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor |
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要素 | Transcriptional enhancer factor TEF-4 |
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キーワード | TRANSCRIPTION / TEAD2 / Inhibitor |
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機能・相同性 | 機能・相同性情報
TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis ...TEAD-YAP complex / lateral mesoderm development / RUNX3 regulates YAP1-mediated transcription / notochord development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / paraxial mesoderm development / hippo signaling / regulation of stem cell differentiation / Formation of axial mesoderm / embryonic heart tube morphogenesis / vasculogenesis / embryonic organ development / cellular response to retinoic acid / neural tube closure / transcription coactivator binding / sequence-specific double-stranded DNA binding / disordered domain specific binding / protein-containing complex assembly / transcription regulator complex / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / intracellular membrane-bounded organelle / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol類似検索 - 分子機能 TEA/ATTS domain / Transcriptional enhancer factor, metazoa / TEA/ATTS domain superfamily / TEA/ATTS domain / TEA domain signature. / TEA domain profile. / TEA domain / YAP binding domain / YAP binding domain類似検索 - ドメイン・相同性 Chem-KXE / MYRISTIC ACID / PALMITIC ACID / Transcriptional enhancer factor TEF-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.22 Å |
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データ登録者 | Sturbaut, M. / Allemand, F. / Guichou, J.F. |
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引用 | ジャーナル: Eur.J.Med.Chem. / 年: 2021 タイトル: Discovery of a cryptic site at the interface 2 of TEAD - Towards a new family of YAP/TAZ-TEAD inhibitors. 著者: Sturbaut, M. / Bailly, F. / Coevoet, M. / Sileo, P. / Pugniere, M. / Liberelle, M. / Magnez, R. / Thuru, X. / Chartier-Harlin, M.C. / Melnyk, P. / Gelin, M. / Allemand, F. / Guichou, J.F. / Cotelle, P. |
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履歴 | 登録 | 2019年7月2日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年7月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年2月2日 | Group: Database references / カテゴリ: citation / citation_author / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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