- PDB-6qzr: 14-3-3 sigma in complex with FOXO1 pT24 peptide -
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Basic information
Entry
Database: PDB / ID: 6qzr
Title
14-3-3 sigma in complex with FOXO1 pT24 peptide
Components
14-3-3 protein sigma
Forkhead box protein O1
Keywords
PEPTIDE BINDING PROTEIN / protein binding / 14-3-3 / FOXO1
Function / homology
Function and homology information
cellular response to hyperoxia / regulation of transcription initiation by RNA polymerase II / AKT-mediated inactivation of FOXO1A / FOXO-mediated transcription of cell cycle genes / AKT phosphorylates targets in the nucleus / positive regulation of smooth muscle cell apoptotic process / neuronal stem cell population maintenance / regulation of neural precursor cell proliferation / response to fatty acid / Regulation of FOXO transcriptional activity by acetylation ...cellular response to hyperoxia / regulation of transcription initiation by RNA polymerase II / AKT-mediated inactivation of FOXO1A / FOXO-mediated transcription of cell cycle genes / AKT phosphorylates targets in the nucleus / positive regulation of smooth muscle cell apoptotic process / neuronal stem cell population maintenance / regulation of neural precursor cell proliferation / response to fatty acid / Regulation of FOXO transcriptional activity by acetylation / regulation of reactive oxygen species metabolic process / negative regulation of stress-activated MAPK cascade / negative regulation of cardiac muscle hypertrophy in response to stress / cellular response to cold / FOXO-mediated transcription of cell death genes / temperature homeostasis / negative regulation of fat cell differentiation / protein acetylation / regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / fat cell differentiation / blood vessel development / intracellular glucose homeostasis / Constitutive Signaling by AKT1 E17K in Cancer / Regulation of gene expression in beta cells / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / cellular response to nitric oxide / canonical Wnt signaling pathway / negative regulation of keratinocyte proliferation / establishment of skin barrier / negative regulation of insulin secretion / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / positive regulation of autophagy / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / energy homeostasis / RHO GTPases activate PKNs / positive regulation of gluconeogenesis / protein sequestering activity / protein kinase A signaling / negative regulation of innate immune response / protein export from nucleus / cellular response to starvation / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / release of cytochrome c from mitochondria / positive regulation of protein export from nucleus / stem cell proliferation / protein phosphatase 2A binding / Translocation of SLC2A4 (GLUT4) to the plasma membrane / promoter-specific chromatin binding / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / MAPK6/MAPK4 signaling / negative regulation of canonical Wnt signaling pathway / chromatin DNA binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / beta-catenin binding / autophagy / positive regulation of protein catabolic process / cellular response to insulin stimulus / intrinsic apoptotic signaling pathway in response to DNA damage / protein localization / insulin receptor signaling pathway / gene expression / cellular response to oxidative stress / positive regulation of cell growth / DNA-binding transcription activator activity, RNA polymerase II-specific / Interleukin-4 and Interleukin-13 signaling / sequence-specific DNA binding / nucleic acid binding / regulation of cell cycle / DNA-binding transcription factor activity, RNA polymerase II-specific / cadherin binding / positive regulation of apoptotic process / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / ubiquitin protein ligase binding / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / mitochondrion / extracellular space / extracellular exosome Similarity search - Function
: / FOXO protein, KIX-binding domain / KIX-binding domain of forkhead box O, CR2 / FOXO protein, transactivation domain / Transactivation domain of FOXO protein family / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 ...: / FOXO protein, KIX-binding domain / KIX-binding domain of forkhead box O, CR2 / FOXO protein, transactivation domain / Transactivation domain of FOXO protein family / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / 14-3-3 domain / Delta-Endotoxin; domain 1 / 14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology
A: 14-3-3 protein sigma B: 14-3-3 protein sigma C: 14-3-3 protein sigma D: 14-3-3 protein sigma E: 14-3-3 protein sigma F: 14-3-3 protein sigma H: 14-3-3 protein sigma G: 14-3-3 protein sigma R: Forkhead box protein O1 J: Forkhead box protein O1 M: Forkhead box protein O1 N: Forkhead box protein O1 O: Forkhead box protein O1 P: Forkhead box protein O1 T: Forkhead box protein O1 U: Forkhead box protein O1 hetero molecules