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Yorodumi- PDB-6pxu: Crystal structure of human GalNAc-T12 bound to a diglycosylated p... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6pxu | |||||||||
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Title | Crystal structure of human GalNAc-T12 bound to a diglycosylated peptide, Mn2+, and UDP | |||||||||
Components |
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Keywords | TRANSFERASE / GalNAc-T / mucin-type O-glycosylation / enzyme catalysis / substrate selectivity / colorectal cancer / CRC | |||||||||
Function / homology | Function and homology information polypeptide N-acetylgalactosaminyltransferase / polypeptide N-acetylgalactosaminyltransferase activity / Defective GALNT12 causes CRCS1 / O-glycan processing / O-linked glycosylation of mucins / carbohydrate binding / membrane => GO:0016020 / Golgi membrane / Golgi apparatus / metal ion binding Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) synthetic construct (others) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.007 Å | |||||||||
Authors | Samara, N.L. / Fernandez, A.J. | |||||||||
Funding support | United States, 2items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2019 Title: The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function. Authors: Fernandez, A.J. / Daniel, E.J.P. / Mahajan, S.P. / Gray, J.J. / Gerken, T.A. / Tabak, L.A. / Samara, N.L. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6pxu.cif.gz | 478.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6pxu.ent.gz | 388.8 KB | Display | PDB format |
PDBx/mmJSON format | 6pxu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/px/6pxu ftp://data.pdbj.org/pub/pdb/validation_reports/px/6pxu | HTTPS FTP |
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-Related structure data
Related structure data | 2ffuS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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