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Yorodumi- PDB-6pve: Structure of Nicotinamide N-Methyltransferase (NNMT) in complex w... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6pve | ||||||||||||||||||
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Title | Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with inhibitor LL319 | ||||||||||||||||||
Components | NNMT protein | ||||||||||||||||||
Keywords | TRANSFERASE/TRANSFERASE Inhibitor / Methyltransferase / Inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex | ||||||||||||||||||
Function / homology | Function and homology information pyridine N-methyltransferase activity / nicotinamide N-methyltransferase / nicotinamide metabolic process / nicotinamide N-methyltransferase activity / Metabolism of ingested SeMet, Sec, MeSec into H2Se / positive regulation of protein deacetylation / NAD biosynthesis via nicotinamide riboside salvage pathway / Methylation / Nicotinamide salvaging / animal organ regeneration ...pyridine N-methyltransferase activity / nicotinamide N-methyltransferase / nicotinamide metabolic process / nicotinamide N-methyltransferase activity / Metabolism of ingested SeMet, Sec, MeSec into H2Se / positive regulation of protein deacetylation / NAD biosynthesis via nicotinamide riboside salvage pathway / Methylation / Nicotinamide salvaging / animal organ regeneration / positive regulation of gluconeogenesis / : / methylation / response to xenobiotic stimulus / cytosol Similarity search - Function | ||||||||||||||||||
Biological species | Homo sapiens (human) | ||||||||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å | ||||||||||||||||||
Authors | Noinaj, N. / Huang, R. / Chen, D. / Yadav, R. | ||||||||||||||||||
Funding support | United States, 5items
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Citation | Journal: J.Med.Chem. / Year: 2019 Title: Novel Propargyl-Linked Bisubstrate Analogues as Tight-Binding Inhibitors for NicotinamideN-Methyltransferase. Authors: Chen, D. / Li, L. / Diaz, K. / Iyamu, I.D. / Yadav, R. / Noinaj, N. / Huang, R. | ||||||||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6pve.cif.gz | 279.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6pve.ent.gz | 181.4 KB | Display | PDB format |
PDBx/mmJSON format | 6pve.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6pve_validation.pdf.gz | 1.6 MB | Display | wwPDB validaton report |
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Full document | 6pve_full_validation.pdf.gz | 1.6 MB | Display | |
Data in XML | 6pve_validation.xml.gz | 46.2 KB | Display | |
Data in CIF | 6pve_validation.cif.gz | 63.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pv/6pve ftp://data.pdbj.org/pub/pdb/validation_reports/pv/6pve | HTTPS FTP |
-Related structure data
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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