登録情報 | データベース: PDB / ID: 6pmc |
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タイトル | TRK-A IN COMPLEX WITH LIGAND 1a |
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要素 | High affinity nerve growth factor receptor |
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キーワード | TRANSFERASE / TRK-A KINASE DOMAIN |
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機能・相同性 | 機能・相同性情報
neurotrophin p75 receptor binding / behavioral response to formalin induced pain / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / neurotrophin receptor activity / programmed cell death involved in cell development / mechanoreceptor differentiation ...neurotrophin p75 receptor binding / behavioral response to formalin induced pain / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / neurotrophin receptor activity / programmed cell death involved in cell development / mechanoreceptor differentiation / nerve growth factor receptor activity / neurotrophin binding / axonogenesis involved in innervation / nerve growth factor signaling pathway / nerve growth factor binding / Sertoli cell development / Retrograde neurotrophin signalling / sympathetic nervous system development / NGF-independant TRKA activation / Signalling to p38 via RIT and RIN / ARMS-mediated activation / positive regulation of programmed cell death / positive regulation of Ras protein signal transduction / positive regulation of synapse assembly / PI3K/AKT activation / Frs2-mediated activation / neurotrophin TRK receptor signaling pathway / detection of temperature stimulus involved in sensory perception of pain / response to electrical stimulus / peptidyl-tyrosine autophosphorylation / Signalling to RAS / detection of mechanical stimulus involved in sensory perception of pain / neuron development / GPI-linked ephrin receptor activity / response to axon injury / positive regulation of GTPase activity / transmembrane receptor protein tyrosine kinase activity / positive regulation of synaptic transmission, glutamatergic / B cell differentiation / axon guidance / cell surface receptor protein tyrosine kinase signaling pathway / response to nutrient levels / peptidyl-tyrosine phosphorylation / cellular response to nerve growth factor stimulus / receptor protein-tyrosine kinase / positive regulation of NF-kappaB transcription factor activity / positive regulation of neuron projection development / cellular response to nicotine / kinase binding / circadian rhythm / recycling endosome membrane / positive regulation of angiogenesis / neuron projection development / late endosome membrane / late endosome / protein autophosphorylation / protein tyrosine kinase activity / early endosome membrane / spermatogenesis / neuron apoptotic process / negative regulation of neuron apoptotic process / learning or memory / early endosome / positive regulation of ERK1 and ERK2 cascade / receptor complex / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / endosome membrane / protein phosphorylation / response to xenobiotic stimulus / axon / negative regulation of cell population proliferation / neuronal cell body / dendrite / negative regulation of apoptotic process / cell surface / protein homodimerization activity / protein-containing complex / mitochondrion / ATP binding / identical protein binding / plasma membrane類似検索 - 分子機能 High affinity nerve growth factor receptor NTRK1 / Tyrosine kinase receptor A, transmembrane domain / Tyrosine kinase receptor A trans-membrane domain / Growth factor receptor NTRK / Growth factor receptor NTRK, leucine rich repeat C-terminal / Leucine rich repeat C-terminal motif / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. ...High affinity nerve growth factor receptor NTRK1 / Tyrosine kinase receptor A, transmembrane domain / Tyrosine kinase receptor A trans-membrane domain / Growth factor receptor NTRK / Growth factor receptor NTRK, leucine rich repeat C-terminal / Leucine rich repeat C-terminal motif / Cysteine-rich flanking region, C-terminal / Leucine rich repeat C-terminal domain / Tyrosine-protein kinase, receptor class II, conserved site / Receptor tyrosine kinase class II signature. / Leucine rich repeat / : / Leucine-rich repeat / Leucine-rich repeat domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Ig-like domain profile. / Immunoglobulin-like domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Immunoglobulin-like domain superfamily / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-OQJ / High affinity nerve growth factor receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.19 Å |
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データ登録者 | Subramanian, G. / Brown, D.G. |
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引用 | ジャーナル: Rsc Med Chem / 年: 2020 タイトル: Synthetic inhibitor leads of human tropomyosin receptor kinase A ( h TrkA). 著者: Subramanian, G. / Vairagoundar, R. / Bowen, S.J. / Roush, N. / Zachary, T. / Javens, C. / Williams, T. / Janssen, A. / Gonzales, A. |
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履歴 | 登録 | 2019年7月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年2月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年2月3日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.name |
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改定 1.2 | 2024年10月30日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Structure summary カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_entry_details / pdbx_modification_feature / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_entry_details.has_protein_modification |
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