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- PDB-6p5p: Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]p... -
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Basic information
Entry | Database: PDB / ID: 6p5p | ||||||
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Title | Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Anti-Tumor Agent | ||||||
![]() | Rho-associated protein kinase 2 | ||||||
![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Inhibitor / Oral / Anti-tumor / TRANSFERASE-TRANSFERASE INHIBITOR / TRANSFERASE-TRANSFERASE INHIBITOR complex | ||||||
Function / homology | ![]() cellular response to acetylcholine / positive regulation of centrosome duplication / positive regulation of connective tissue growth factor production / positive regulation of amyloid precursor protein catabolic process / regulation of angiotensin-activated signaling pathway / Rho-dependent protein serine/threonine kinase activity / negative regulation of protein localization to lysosome / positive regulation of connective tissue replacement / regulation of keratinocyte differentiation / positive regulation of fibroblast growth factor production ...cellular response to acetylcholine / positive regulation of centrosome duplication / positive regulation of connective tissue growth factor production / positive regulation of amyloid precursor protein catabolic process / regulation of angiotensin-activated signaling pathway / Rho-dependent protein serine/threonine kinase activity / negative regulation of protein localization to lysosome / positive regulation of connective tissue replacement / regulation of keratinocyte differentiation / positive regulation of fibroblast growth factor production / response to transforming growth factor beta / negative regulation of myosin-light-chain-phosphatase activity / regulation of nervous system process / regulation of cell junction assembly / negative regulation of bicellular tight junction assembly / modulation by host of viral process / regulation of cellular response to hypoxia / positive regulation of protein localization to early endosome / embryonic morphogenesis / negative regulation of nitric oxide biosynthetic process / negative regulation of biomineral tissue development / cellular response to testosterone stimulus / regulation of establishment of endothelial barrier / RHO GTPases Activate ROCKs / regulation of stress fiber assembly / regulation of cell motility / actomyosin structure organization / Sema4D induced cell migration and growth-cone collapse / response to angiotensin / aortic valve morphogenesis / regulation of establishment of cell polarity / RHOBTB1 GTPase cycle / cortical actin cytoskeleton organization / regulation of focal adhesion assembly / RHOB GTPase cycle / positive regulation of amyloid-beta formation / tau-protein kinase activity / EPHA-mediated growth cone collapse / mRNA destabilization / positive regulation of cardiac muscle hypertrophy / RHOC GTPase cycle / centrosome duplication / RHOH GTPase cycle / Rho protein signal transduction / mitotic cytokinesis / endopeptidase activator activity / smooth muscle contraction / RHOA GTPase cycle / epithelial to mesenchymal transition / canonical NF-kappaB signal transduction / regulation of cell adhesion / positive regulation of stress fiber assembly / EPHB-mediated forward signaling / positive regulation of endothelial cell migration / blood vessel diameter maintenance / negative regulation of angiogenesis / protein localization to plasma membrane / response to ischemia / regulation of actin cytoskeleton organization / tau protein binding / regulation of circadian rhythm / small GTPase binding / VEGFA-VEGFR2 Pathway / cytoplasmic ribonucleoprotein granule / G alpha (12/13) signalling events / rhythmic process / actin cytoskeleton organization / protease binding / Potential therapeutics for SARS / positive regulation of MAPK cascade / cytoskeleton / non-specific serine/threonine protein kinase / positive regulation of cell migration / positive regulation of protein phosphorylation / protein phosphorylation / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / positive regulation of gene expression / structural molecule activity / RNA binding / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Hoffman, I.D. / Skene, R.J. | ||||||
![]() | ![]() Title: Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent. Authors: Kurasawa, O. / Miyazaki, T. / Homma, M. / Oguro, Y. / Imada, T. / Uchiyama, N. / Iwai, K. / Yamamoto, Y. / Ohori, M. / Hara, H. / Sugimoto, H. / Iwata, K. / Skene, R. / Hoffman, I. / Ohashi, ...Authors: Kurasawa, O. / Miyazaki, T. / Homma, M. / Oguro, Y. / Imada, T. / Uchiyama, N. / Iwai, K. / Yamamoto, Y. / Ohori, M. / Hara, H. / Sugimoto, H. / Iwata, K. / Skene, R. / Hoffman, I. / Ohashi, A. / Nomura, T. / Cho, N. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 626.4 KB | Display | ![]() |
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PDB format | ![]() | 527 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 438.9 KB | Display | ![]() |
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Full document | ![]() | 441.1 KB | Display | |
Data in XML | ![]() | 1.9 KB | Display | |
Data in CIF | ![]() | 15.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 6p5mC ![]() 2f2uS S: Starting model for refinement C: citing same article ( |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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